2012
DOI: 10.5402/2012/928901
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Synthesis, Urease Inhibition, Antioxidant, Antibacterial, and Molecular Docking Studies of 1,3,4-Oxadiazole Derivatives

Abstract: A series of eighteen 1,3,4-oxadiazole derivatives have been synthesized by treating aromatic acid hydrazides with carbon disulfide in ethanolic potassium hydroxide yielding potassium salts of 1,3,4-oxadiazoles. Upon neutralization with 1 N hydrochloric acid yielded crude crystals of 1,3,4-oxadiazoles, which were purified by recrystallization in boiling methanol. The synthesized 1,3,4-oxadiazoles derivatives were evaluated in vitro for their urease inhibitory activities, most of the investigated compounds were … Show more

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Cited by 51 publications
(39 citation statements)
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“…The J values of the analyzed compounds are presented in Hertz (Hz). The spectra of 13 C -NMR were recorded at a frequency of 75.5 MHz or 125 MHz. EIMS spectra were obtained using Agilent TOF-6220 analyzer, while the elements were analyzed on a Perkin Elmer 2400 CHN instrument.…”
Section: Experimental Analytical Proceduresmentioning
confidence: 99%
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“…The J values of the analyzed compounds are presented in Hertz (Hz). The spectra of 13 C -NMR were recorded at a frequency of 75.5 MHz or 125 MHz. EIMS spectra were obtained using Agilent TOF-6220 analyzer, while the elements were analyzed on a Perkin Elmer 2400 CHN instrument.…”
Section: Experimental Analytical Proceduresmentioning
confidence: 99%
“…In this regard, high throughput virtual and in vitro biological assay of molecules to understand their molecular behaviour in specific environments, will aid the identification of potent molecules from a crude cocktail [12]. Recently, 1,3,4-oxadiazole-2-thiones derivatives have been investigated as active jack bean urease inhibitors with promising anti-urease activities [13]. The aim of the current study was to synthesize Mannich bases derived from 1, 3, 4-oxadiazole-2-thione bearing 3, 4, 5-trimethoxy moiety and examine them as potential urease inhibitors and antioxidant agents.…”
Section: Introductionmentioning
confidence: 99%
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“…In reality more effective and potent compounds are mandatory with a complete new level of safety and specificity. Urease inhibitors for this purpose have gained incredible attention in recent times and therefore resulted into the discovery of numerous inhibitors [8,[10][11][12][13].…”
Section: Editorialmentioning
confidence: 99%
“…These inhibitors generally divided into two classes, substrate structural analogs like hydroxamic acid (Kobashi K 1962,;Krajewska B 2009;Muri EMF 2003) and those which affect the mechanism of the reaction like phosphoramidat (Amtul Z 2002;Kot M 2001). Lansoprazole (Nagata K 1993), omeprazole (Kuehler TC 1995), thiol-compounds (Todd MJ 1989), quinines (Bundy LG 1973) and schiff base derivatives (Hanif M 2012) are reported as potent urease inhibitors.…”
Section: Introductionmentioning
confidence: 99%