Synthesis, biological evaluation and molecular docking studies of Mannich bases derived from 1, 3, 4-oxadiazole- 2-thiones as potential urease inhibitors

Abstract

Purpose: To design and synthesize a series of new structural motifs of urease inhibitors, 3-[{(substituted phenyl) amino} methyl]-5-(3, 4, 5-trimethoxyphenyl)-1,3,4-oxadiazole-2(3H)-thiones and 3-{[(pyridin-2-yl)amino]methyl}- 5-(3,4,5-trimethoxy phenyl)-1,3,4-oxadiazole-2(3H) 4,5,9,10,12,13, values in the range of 5. 93 ± 0.13 to 9.76 ± 0.11,

Synthesis, Biological Evaluation andin SilicoStudies of 3‐Hydroxy‐N‐(2‐(substituted phenyl)‐4‐oxothiazolidin‐3‐yl)‐2‐napthamide Derivatives

“…According to Akram et al . the presence of electron donating group, 3,4,5‐tri‐OCH 3 , group enhanced the antioxidant activity and same pattern was observed in our study [49] …”

“…[48] * Amid synthesized derivatives, compounds S2 (R 3 =OH), exhibited better antioxidant activity which in concordance with Aziz et al [48] According to Akram et al the presence of electron donating group, 3,4,5-tri-OCH 3 , group enhanced the antioxidant activity and same pattern was observed in our study. [49]…”

Optimizing the interaction between a new complex of platinum and copper with immunoproteins

“…General procedure for the synthesis of ligand A 0.001 mole (0.214 g) of 6-Methoxy-2-naphthylacetic acid was mixed with 15 mL of Methanol and 10 drops of H2SO4 was added gradually to solution of . The mixture was refluxed at 60 o C for 4 h. An ester product precipitate was separated out and washed with acetone Akram et al, 2018 The ester product 0.001mole(0.22 g) was refluxed with hydrazine (10.5 mL ) in presence of methanol and refluxed at 60 o C for 1.5 h. An amide product precipitate was separated out and washed with acetone (Al-Jeboori, Abdul-Ghani and Al-Karawi, 2008). The amide product0.001mole (0.22g) was refluxed with CS2 (7.5 mL) in presence of methanol and KOH and then refluxed at 70 o C for 2 h. A thiolate salt product precipitate was separated out and washed with acetone.…”