A series of eighteen 1,3,4-oxadiazole derivatives have been synthesized by treating aromatic acid hydrazides with carbon disulfide in ethanolic potassium hydroxide yielding potassium salts of 1,3,4-oxadiazoles. Upon neutralization with 1 N hydrochloric acid yielded crude crystals of 1,3,4-oxadiazoles, which were purified by recrystallization in boiling methanol. The synthesized 1,3,4-oxadiazoles derivatives were evaluated in vitro for their urease inhibitory activities, most of the investigated compounds were potent inhibitors of Jack bean urease. The molecular docking studies were performed by docking them into the crystal structure of Jack bean urease to observe the mode of interaction of synthesized compounds. The synthesized compounds were also tested for antibacterial and antioxidant activities and some derivatives exhibited very promising results.
Mon ami(ne)! A general and convenient methodology for 2-aminobenzoxazinone synthesis has been developed (see scheme). Readily available 2-bromoanilines and isocyanates were used as substrates and various products have been prepared in good yields. Notably, [Mo(CO)6] as a solid CO source was applied instead of gas.
The ligands were synthesized by the reported methods [11]. General procedure for synthesis of transition metal complexes Transition metal complexes were prepared by mixing the corresponding ligands with transition metals Cu(CH 3 COO) 2 .2H 2 O, Co(CH 3 COO) 2 .4H 2 O, Ni(CH 3 COO) 2 .4H 2 O, Mn (CH 3 COO) 2 .4H 2 O and Zn (CH 3 COO) 2 .2H 2 O. Synthesis To a solution of HL 1 or HL 2 in methanol (20 ml) a solution of metal salts in 15 ml methanol in 2:1 molar ratio was added drop wise. The reaction mixture was refluxed for 3-6 hours at 60°C. The precipitates were formed.
The Suzuki-Miyaura reaction of 2,6-dichloro-3-(trifluoromethyl)pyridine with 1 equiv of arylboronic acids resulted in site-selective formation of 2-aryl-6-chloro-3-(trifluoromethyl)pyridine. Due to electronic reasons, the reaction takes place at the sterically more hindered position. The selectivity was rationalised by DFT calculations. The one-pot reaction with two different arylboronic acids afforded 2,6-diaryl-3-(trifluoromethyl)pyridine containing two different aryl substituents. The reactions proceeded smoothly in the absence of phosphine ligands. In addition, Suzuki-Miyaura reactions of 2,6-dichloro-4-(trifluoromethyl)pyridine with one or two equivalents of arylboronic acids were carried out.
Docking Studies. -26 Title compounds are prepared and preliminarily screened for their in vitro urease inhibition and antifungal activity. (IIIb) shows potent urease inhibitory activity, (IIIb) and (IIIc) show equipotent antifungal activities as compared to the standard, and (IIIe) exhibits antioxidant activity. -(RAUF, M. K.; TALIB, A.; BADSHAH*, A.; ZAIB, S.; SHOAIB, K.; SHAHID, M.; FLOERKE, U.; IMTIAZ-UD-DIN, U.; IQBAL, J.; Eur. J. Med. Chem. 70 (2013) 487-496, http://dx.
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