Synthesis, swelling properties, and network structure of new stimuli‐responsive poly(N‐acryloyl‐N′‐ethyl piperazine‐co‐N‐isopropylacrylamide) hydrogels

Deen, G. Roshan; Chua, Vivien; Ilyas, Usman

doi:10.1002/pola.26124

Cited by 17 publications

(5 citation statements)

References 60 publications

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“…As it could be observed, all n sw values are below 0.5, which led to the conclusion that an anomalous mechanism of swelling occurred. This case is called a “less Fickian” behavior as already mentioned above but is also the case for swelling with other hydrogels [ 58 , 59 , 60 ].…”

Section: Resultsmentioning

confidence: 98%

Toxicity, Biocompatibility, pH-Responsiveness and Methotrexate Release from PVA/Hyaluronic Acid Cryogels for Psoriasis Therapy

et al. 2017

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Poly(vinyl alcohol)/hyaluronic acid cryogels loaded with methotrexate were studied. The physical-chemical characterization of cryogels was performed by FT-IR spectroscopy, scanning electron microscopy, differential scanning calorimetry and dynamic mechanical thermal analysis. Acute toxicity and haematological parameters were determined by "in vivo" tests. The biocompatibility tests proved that the obtained cryogels showed significantly decreased toxicity and are biocompatible. The pH-responsiveness of the swelling behaviour and of the methotrexate release from the poly(vinyl alcohol)/hyaluronic acid (PVA/HA) cryogels were studied in a pH interval of 2-7.4. A significant change in properties was found at pH 5.5 specific for treatment of affected skin in psoriasis disease.

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Section: Resultsmentioning

confidence: 98%

Toxicity, Biocompatibility, pH-Responsiveness and Methotrexate Release from PVA/Hyaluronic Acid Cryogels for Psoriasis Therapy

et al. 2017

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“…In most published reports on the hydrogel swelling, values of n close to 0.5 or over 0.5 are presented. Only a few papers report values of n<0.5 [25,[43][44][45][46][47].…”

Section: Case III (Or Anomalous Diffusion Non-fickian Diffusion)mentioning

confidence: 99%

pH-responsive hydrogel membranes based on modified chitosan: water transport and kinetics of swelling

2015

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pH-responsive membranes prepared by treating chitosan (Ch) with glutaraldehyde (GA) or with GA and sulfuric acid (SA) were studied. The structure and properties of the membranes were characterized by Fourier transform infrared (FTIR) spectroscopy, wide-angle X-ray diffraction (WAXD), scanning electron microscopy (SEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC) and elemental analysis. The effect of the cross-linking process both on the dynamic swelling behaviour of the hydrogel membranes and on the mechanism of water transport through those membranes was investigated in buffer solutions of different pH (1.2-9.5). The mechanism of water transport through the hydrogel chitosan membranes was affected by membrane composition and pH of the swelling medium. Non-cross-linked Ch membrane showed a non-Fickian swelling behaviour in the pH range 6.5-9.5. Chitosan membrane cross-linked with GA (Ch/GA) showed less-Fickian or Fickian swelling behaviour in all buffer solutions. In the case of chitosan membrane cross-linked with GA and SA (Ch/GA/SA), at low pH (lower than the pK a of the hydrogel) the water transport was controlled more by polymer relaxation than by penetrant diffusion. The experimental data clearly suggested that the swelling process in all buffer solutions obeyed second-order kinetics. Values of an apparent swelling rate constant for Ch/ GA and Ch/GA/SA membranes were of the same order of magnitude for acidic and neutral swelling media but they increased for alkaline solutions.

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“…The volume phase transition temperature (VPT) of the gels A1N9 and A7N3 were measured to be 36 °C and 64.8 °C respectively which were in agreement with the LCST of the corresponding linear polymers [45]. This increase in VPT of A7N3 is due to the presence of a high amount of AcrNEP which is a hydrophilic comonomer.…”

Section: Resultsmentioning

confidence: 56%

Synthesis and Properties of New “Stimuli” Responsive Nanocomposite Hydrogels Containing Silver Nanoparticles

Deen

Chua

2015

Gels

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Hydrogel nanocomposites containing silver nanoparticles of size 15–21 nm were prepared by diffusion and in-situ chemical reduction in chemically crosslinked polymers based on N-acryloyl-N′-ethyl piperazine (AcrNEP) and N-isopropylacrylamide (NIPAM). The polymer chains of the hydrogel network offered control and stabilization of silver nanoparticles without the need for additional stabilizers. The presence of silver nanoparticles and their size was quantified by UV-Vis absorption spectroscopy and scanning electron microscopy. The nanocomposite hydrogels were responsive to pH and temperature changes of the external environment. The equilibrium weight swelling ratio of the hydrogel nanocomposite was lower in comparison with the precursor hydrogel. Silver nanoparticles present in the nanocomposite offered additional physical crosslinking which influenced media diffusion and penetration velocity. The release of silver nanoparticles from the hydrogel matrix in response to external pH changes was studied. The rate of release of silver nanoparticles was higher in a solution of pH 2.5 due to maximum swelling caused by ionization of the gel network. No significant release of nanoparticles was observed in a solution of pH 7.

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Synthesis, swelling properties, and network structure of new stimuli‐responsive poly(N‐acryloyl‐N′‐ethyl piperazine‐co‐N‐isopropylacrylamide) hydrogels

Cited by 17 publications

References 60 publications

Toxicity, Biocompatibility, pH-Responsiveness and Methotrexate Release from PVA/Hyaluronic Acid Cryogels for Psoriasis Therapy

Toxicity, Biocompatibility, pH-Responsiveness and Methotrexate Release from PVA/Hyaluronic Acid Cryogels for Psoriasis Therapy

pH-responsive hydrogel membranes based on modified chitosan: water transport and kinetics of swelling

Synthesis and Properties of New “Stimuli” Responsive Nanocomposite Hydrogels Containing Silver Nanoparticles

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