Synthesis, structure and properties of ruthenium(II) complexes with quinolinedione derivatives as chelate ligands: Crystal structure of [Ru(CO)2Cl2(6-methoxybenzo[g]quinoline-5,10-dione)]

Prieto, Yolanda; Muñoz, Marcelo; Arancibia, Veróníca; Valderrama, Mauricio; Lahoz, Fernando J.; Martı́n, Marta

doi:10.1016/j.poly.2007.08.014

Cited by 15 publications

(14 citation statements)

References 28 publications

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“…The voltammograms were run in the potential range 0.0-2.0 V versus non-aqueous Ag/Ag+ [18]. The first half-wave potential values, E I 1/2 , evaluated from the voltammograms obtained at a sweep rate of 100 mV s −1 .…”

Section: Scheme 1 Synthesis Of 7-anilino-1-aryl-6-bromoisoquinolineqmentioning

confidence: 99%

Antiproliferative Activity of New 6-Bromine Derivatives of 7-Anilino-1-Arylisoquinolinequinones

Ibacache

Valderrama

Arancibia

et al. 2016

J. Chil. Chem. Soc.

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A variety of 6-bromine-containing 7-anilino-1-arylisoquinolinequinones 2a-g were synthesized to evaluate their half-wave potentials and in vitro antiproliferative activity on gastric and leukemia cancer cell lines. The new compounds displayed significant IC50 values in the range: 1.31 to 11.04 µM. The structure activity relationship analysis of the new series suggest that the antiproliferative activity is dependent, in part, on the push-pull electronic effects of the nitrogen and bromine substituents inserted into the redox fragment of the 1-arylisoquinolinequinone scaffold. Linear regression analysis provided satisfactory relationships between the log IC50 and ClogP values for the AGS gastric cancer cell line.

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Section: Scheme 1 Synthesis Of 7-anilino-1-aryl-6-bromoisoquinolineqmentioning

confidence: 99%

Antiproliferative Activity of New 6-Bromine Derivatives of 7-Anilino-1-Arylisoquinolinequinones

Ibacache

Valderrama

Arancibia

et al. 2016

J. Chil. Chem. Soc.

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“…The a-iminoketo chelation plays an important role in the biosynthesis of the pterins, lumazines, flavins coenzymes [3,4]. However, the number of structurally characterized of transition metal complexes incorporating such ligands is relatively rare [5].…”

Section: Introductionmentioning

confidence: 99%

“…Continuing our researches on the tricarbonyl rhenium complexes, we have examined the reactivity of two 5,8-quinolinedione derivatives, namely 7-acetamido-2-methyl-quinoline-5,8-dione (1) and 6-acetamido-2-methyl-quinoline-5,8-dione (2) (Scheme 1) towards Re (CO) 5 Cl in order to study of their coordination modes in dependence of the position of the acetamido group.…”

Section: Introductionmentioning

confidence: 99%

Novel tricarbonyl rhenium complexes of 5,8-quinolinedione derivatives – Synthesis, spectroscopic characterisation, X-ray structure and DFT calculations

Machura

Świtlicka

Wolff

et al. 2011

Journal of Organometallic Chemistry

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“…Ruthenium(II) complexes have long been investigated for their potential utility in chemotherapy and photodynamic therapy which is attributed to their structural similarity to cis-platinum [1][2][3][4][5][6][7][8]. In recent years a number of ruthenium complexes have been designed, and their antitumor activity, as well as their interaction with double strand DNA molecules has been studied extensively.…”

Section: Introductionmentioning

confidence: 99%

Studies on the interactions of a novel ruthenium(II) complex with G-quadruplex DNA

Mei

Wei

Liu

et al. 2008

Transition Met Chem

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A novel ruthenium(II) porphyrin complex, [Ru(phen) 2 MPyTPP] (phen = phenanthroline, MPyTPP = mono-(3 0 -Pyridine)-10,15,20-triphenyl porphyrin), has been prepared and characterized by elemental analysis, ESI-MS and NMR methods. The interaction of the complex with G-quadruplex DNA has been studied by spectroscopy, and the results have shown that [Ru(phen) 2 MPyTPP] can bind to G-quadruplex d(TTAGGG) 4 with high affinity. In the presence of d(TTAGGG) 4 , the characteristic Soret and intra-ligand (IL) transitions in the UV-Vis spectrum of the complex exhibit hypochromism of 25% (Dk = 6 nm) and 18% (Dk = 1 nm), respectively. The intrinsic binding constant was calculated according to the decay of the Soret band as 3.02(±0.08) 9 10 6 M -1 . The positive signal of d(TTAGGG) 4 in its circular dichroism spectra was clearly decreased in the presence of the complex, indicating the conformation of the G-quadruplex was severely disturbed by the ruthenium(II) complex.

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Synthesis, structure and properties of ruthenium(II) complexes with quinolinedione derivatives as chelate ligands: Crystal structure of [Ru(CO)2Cl2(6-methoxybenzo[g]quinoline-5,10-dione)]

Cited by 15 publications

References 28 publications

Antiproliferative Activity of New 6-Bromine Derivatives of 7-Anilino-1-Arylisoquinolinequinones

Antiproliferative Activity of New 6-Bromine Derivatives of 7-Anilino-1-Arylisoquinolinequinones

Novel tricarbonyl rhenium complexes of 5,8-quinolinedione derivatives – Synthesis, spectroscopic characterisation, X-ray structure and DFT calculations

Studies on the interactions of a novel ruthenium(II) complex with G-quadruplex DNA

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