Synthesis, structure and anticancer activity of three platinum(II) complexes with 2-phenylpyridine derivatives

Niu, Luyao; Ren, Guolian; Hou, Tianjiao; Shen, Xuan; Zhu, Dunru

doi:10.1016/j.inoche.2021.108737

Cited by 14 publications

(11 citation statements)

References 28 publications

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“…Moreover, the antiproliferative activity of the present complexes is much better toward the HepG2 cell line than that reported for Pd( ii ) and Pt( ii ) complexes. 55 Interestingly, the cytotoxicity of the platinum complex was nearly comparable to that of the standard anticancer drug, cisplatin in HepG2 cell line. Whereas the free ligand HL did not show any noticeable cytotoxicity toward the above-mentioned cell lines.…”

Section: Resultsmentioning

confidence: 98%

Palladium(ii) and platinum(ii) complexes with ONN donor pincer ligand: synthesis, characterization and in vitro cytotoxicity study

et al. 2022

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Section: Resultsmentioning

confidence: 98%

Palladium(ii) and platinum(ii) complexes with ONN donor pincer ligand: synthesis, characterization and in vitro cytotoxicity study

et al. 2022

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“…Even with achiral ligands, both precursors have a pair of enantiomers in their single crystals (Figures S20 and S21). , Therefore, we guessed that the chiral ( R )-/( S )-BINA-OXT ligand might go through a chiral self-sorting process to choose an interaction partner with a given chirality from the racemic precursors and consequently cause homochiral R / S planar chirality during coordination.…”

Section: Results and Discussionmentioning

confidence: 99%

Highly Phosphorescent Planar Chirality by Bridging Two Square-Planar Platinum(II) Complexes: Chirality Induction and Circularly Polarized Luminescence

et al. 2022

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Chiral organometallic complexes have demonstrated many potential and practical applications. However, building metal-induced chirality for square-planar complexes still remains a big challenge, because their 2D planar molecular structures are usually superimposable on their mirror images. Herein, we report a straightforward and efficient way to achieve a novel kind of planar chirality by constructing 3D double-layer molecular structures. When the achiral ligand 1,3,4-oxadiazole-2-thiol (OXT) was used to bridge two square-planar complexes, a pair of racemic R/S planar-chiral binuclear Pt(II) complexes was obtained, which could be separated by chiral high-performance liquid chromatography (HPLC). Moreover, enantiopure R,R,R or S,S,S complexes could be prepared by the use of chiral (R)-/(S)-binaphthalene-derived OXT ligands in 99% diastereoselectivity without the use of chiral HPLC. The binaphthalene groups help to ensure good solubility and a smooth amorphous thin film morphology but have little effect on the photophysical properties. The resultant complexes display strong orange-red and near-infrared phosphorescence with quantum yields of up to 83.4% and can be applied as emitters in highly efficient solution-processed organic light-emitting diodes to achieve luminance, luminance efficiency, external quantum efficiency, and an asymmetry factor of up to 3.22 × 104 cd m–2, 28.7 cd A–1, 14.3%, and 2.0 × 10–3, respectively. With a comprehensive consideration of EL efficiency and the asymmetry factor, this is the best performance among Pt(II) complex based circularly polarized OLEDs. Therefore, this work provides a new and simple strategy to build planar chirality for chiroptical and circularly polarized luminescence applications.

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“…12) asserting their efficacy in an order of HCT 116 > HepG2 > A549 using cisplatin and doxorubicin (Dox) as positive controls. 58 Hence, HCT 116 cells have been chosen for further study. Moreover, HL and normal PBMC cells (human peripheral blood mononuclear cells) have shown significantly higher IC 50 values in all three cell types than the other two compounds (ESI,† Fig.…”

Section: Resultsmentioning

confidence: 99%

New palladium(ii) and platinum(ii) complexes with an ONS donor azo-thioether pincer ligand: synthesis, characterization, protein binding study and in vitro cytotoxicity

et al. 2023

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Synthesis, structure and anticancer activity of three platinum(II) complexes with 2-phenylpyridine derivatives

Cited by 14 publications

References 28 publications

Palladium(ii) and platinum(ii) complexes with ONN donor pincer ligand: synthesis, characterization and in vitro cytotoxicity study

Palladium(ii) and platinum(ii) complexes with ONN donor pincer ligand: synthesis, characterization and in vitro cytotoxicity study

Highly Phosphorescent Planar Chirality by Bridging Two Square-Planar Platinum(II) Complexes: Chirality Induction and Circularly Polarized Luminescence

New palladium(ii) and platinum(ii) complexes with an ONS donor azo-thioether pincer ligand: synthesis, characterization, protein binding study and in vitro cytotoxicity

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