Palladium(<scp>ii</scp>) and platinum(<scp>ii</scp>) complexes with ONN donor pincer ligand: synthesis, characterization and <i>in vitro</i> cytotoxicity study

Bera, Biswajit; Mondal, Sanchaita; Gharami, Saswati; Naskar, Rahul; Saha, Krishna Das; Mondal, Tapan Kumar

doi:10.1039/d2nj01894b

Cited by 5 publications

(10 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These deviations from the ideal trans angle of 180 caused a considerable deformation in the complexes' square planar geometry. In C1, Pd1-N1 (1.998(2) Å), Pd1-N3 (1.992(2) Å), and Pd1-Cl1 (2.3026(7) Å) bond distances are in good agreement with the reported values of known palladium complexes, [51][52][53][54][55] while for C2, Pt1-N1 (1.988(3) Å), Pt1-N3 (1.989(3) Å), and Pt1-Cl1 (2.3032(10) Å) bond distances are also found to be comparable with the reported values (Table S2). 51,54-59…”

Section: Crystal Structure Descriptionssupporting

confidence: 85%

“…The IC 50 value of the Pd‐complex ( C1 ) (15.3 ± 1.8) was higher than that of Pt complex ( C2 ). So it can be stated that the ligand was not the key factor of the cytotoxicity as in spite of having the same ligand Pt complex showed a better activity than that of Pd complex 51 . The IC 50 values for C1 and C2 towards normal cells PBMC were found to be higher than 200 μM, suggesting that the complexes were less toxic towards the normal cell line.…”

Section: Resultsmentioning

confidence: 96%

See 1 more Smart Citation

New palladium (II) and platinum (II) complexes with coumarin based O,N,N pincer: Synthesis, structure elucidation, BSA protein binding studies, and anticancer activity

Bera

Mondal

Mandal

et al. 2023

Applied Organom Chemis

Self Cite

View full text Add to dashboard Cite

New Pd (II) and Pt (II) complexes (C1/C2) with a O,N,N donor pincer ligand, 4‐hydroxy‐3‐((E)‐1‐(((Z)‐phenyl (pyridin‐2‐yl)methylene)hydrazono)ethyl)‐2H‐chromen‐2‐one (HL) were synthesized and methodically characterized by several spectroscopic and XRD techniques. Absorption and fluorescence techniques were used to assess the mechanism of interaction of the complexes with bovine serum albumin protein. MTT assay was executed to investigate the antiproliferative activity of the complexes with several cancer cell lines (MCF‐7, HCT116, A549, and HepG2) along with a normal cell line (PBMC). Both C1 and C2 showed better antiproliferative activity with HepG2 cell line (IC50 value of 15.3 and 5.1 μM, respectively). A cytotoxicity study was performed, and complex C2 exhibited a better antiproliferative activity as compared to C1. The morphological changes were also examined by staining methods, and fragmented DNA unveiled that the cell death took place through apoptosis.

show abstract

Section: Crystal Structure Descriptionssupporting

confidence: 85%

Section: Resultsmentioning

confidence: 96%

New palladium (II) and platinum (II) complexes with coumarin based O,N,N pincer: Synthesis, structure elucidation, BSA protein binding studies, and anticancer activity

Bera

Mondal

Mandal

et al. 2023

Applied Organom Chemis

Self Cite

View full text Add to dashboard Cite

show abstract

“…Therefore, all the chemicals were utilized without any further purification. Ligand HL was synthesized by previous procedure . Infrared spectra (IR) were recorded on a Perkin-Elmer FT-IR spectrometer (4000–400 cm –1 ) in KBr pellets.…”

Section: Methodsmentioning

confidence: 99%

“…Ligand HL was synthesized by previous procedure. 70 Infrared spectra (IR) were recorded on a Perkin-Elmer FT-IR spectrometer (4000−400 cm −1 ) in KBr pellets. 1 H NMR spectra of the compounds were collected from a Bruker 300 MHz instrument in CDCl 3 and DMSOd 6 medium (mentioned in each spectrum).…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Heavy Metal-Based Binuclear Luminescent Complexes for Selective and Swift Sensing of Nitro-Explosives in Solution and Solid Phases

Bera

Mandal

Gharami

et al. 2023

Crystal Growth & Design

Self Cite

View full text Add to dashboard Cite

Discerning the detection of 2,4,6-trinitrophenol (TNP)-like mutagenic pollutants and other nitroaromatic-based explosives (NACs) using robust luminescent metal complexes has been always a potential research field. Herein, we report the synthesis of three novel luminescent chloro-bridged heavy metal complexes of formulation [M2(HL)2Cl4] where M stands for Zn2+, Cd2+, and Hg2+ for complexes 1, 2, and 3, respectively, by refluxing the mixture of ligand HL and metal chloride salts. Single-crystal X-ray study, spectroscopic (1H NMR, FT-IR, UV–vis, and emission spectroscopy) techniques, DFT, and TDDFT calculations have all been used to fully characterize the complexes. All the three complexes exhibit excellent fluorescence responses which get quenched in the presence of different NACs. Interestingly, the fluoroprobes (1–3) are more selective and sensitive toward TNP over several other comparative NACs with high (in the order of ∼104 M–1) quenching constants (K SV) and nanomolar detection limit (LOD), and complex-coated TLC plates were used to detect TNP in the solid state. Moreover, our probes were quite sensitive for the trace detection of TNP in real samples. Among the three, complex 3 is the most efficacious with K SV (5.19 ± 0.12) × 104 M–1 and LOD of 180.2 nM. 1H NMR and fluorescence lifetime titration of probes with TNP shed light on the nature of the interaction (dynamic quenching) of probes with TNP. In addition, DFT and UV–vis absorption of probes with TNP proved that the quenching phenomenon could be primarily ascribed to photo-induced electron transfer (PET) and resonance energy transfer (RET).

show abstract

“…A Pt(II) complex with an ONN-“pincer” ligand [ 37 ] showed significant antiproliferative effect against Hep-G2 cells (IC 50 = 6 to 12 μM), comparable to cisplatin. Activity against normal hPBMC was very mild, where IC 50 > 200 μM.…”

Section: Novel Metal Complexes In Cancer Therapymentioning

confidence: 99%

Recent Trends in the Development of Novel Metal-Based Antineoplastic Drugs

Todorov

Kostova

2023

Molecules

View full text Add to dashboard Cite

Since the accidental discovery of the anticancer properties of cisplatin more than half a century ago, significant efforts by the broad scientific community have been and are currently being invested into the search for metal complexes with antitumor activity. Coordination compounds of transition metals such as platinum (Pt), ruthenium (Ru) and gold (Au) have proven their effectiveness as diagnostic and/or antiproliferative agents. In recent years, experimental work on the potential applications of elements including lanthanum (La) and the post-transition metal gallium (Ga) in the field of oncology has been gaining traction. The authors of the present review article aim to help the reader “catch up” with some of the latest developments in the vast subject of coordination compounds in oncology. Herewith is offered a review of the published scientific literature on anticancer coordination compounds of Pt, Ru, Au, Ga and La that has been released over the past three years with the hope readers find the following article informative and helpful.

show abstract

Palladium(ii) and platinum(ii) complexes with ONN donor pincer ligand: synthesis, characterization and in vitro cytotoxicity study

Cited by 5 publications

References 79 publications

New palladium (II) and platinum (II) complexes with coumarin based O,N,N pincer: Synthesis, structure elucidation, BSA protein binding studies, and anticancer activity

New palladium (II) and platinum (II) complexes with coumarin based O,N,N pincer: Synthesis, structure elucidation, BSA protein binding studies, and anticancer activity

Heavy Metal-Based Binuclear Luminescent Complexes for Selective and Swift Sensing of Nitro-Explosives in Solution and Solid Phases

Recent Trends in the Development of Novel Metal-Based Antineoplastic Drugs

Contact Info

Product

Resources

About