Synthesis, structural characterisation and antibacterial activity of Ag+-doped fluorapatite nanomaterials prepared by neutralization method

Stanić, Vojislav; Radosavljević-Mihajlović, Ana; Živković-Radovanović, Vukosava; Nastasijević, Branislav; Marinović‐Cincović, Milena; Marković, Jelena; Budimir, Milica

doi:10.1016/j.apsusc.2015.02.065

Cited by 43 publications

(20 citation statements)

References 55 publications

(73 reference statements)

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“…However, the use of small amounts of fluoride in these products results from its beneficial effects on the development of teeth and bones (fluorine stimulates osteoblast activity and thus accelerates bone regeneration). It protects tooth enamel from demineralization and thus caries [57,58,59]. It is also known that fluoride ions can substitute hydroxyl groups in enamel apatite, resulting in the formation of FA or FHA.…”

Section: The Role Of Ha and Fa In Conservative Dentistrymentioning

confidence: 99%

Hydroxyapatite and Fluorapatite in Conservative Dentistry and Oral Implantology—A Review

2019

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Calcium phosphate, due to its similarity to the inorganic fraction of mineralized tissues, has played a key role in many areas of medicine, in particular, regenerative medicine and orthopedics. It has also found application in conservative dentistry and dental surgery, in particular, as components of toothpaste and mouth rinse, coatings of dental implants, cements, and bone substitute materials for the restoration of cavities in maxillofacial surgery. In dental applications, the most important role is played by hydroxyapatite and fluorapatite, i.e., calcium phosphates characterized by the highest chemical stability and very low solubility. This paper presents the role of both apatites in dentistry and a review of recent achievements in the field of the application of these materials.

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Section: The Role Of Ha and Fa In Conservative Dentistrymentioning

confidence: 99%

Hydroxyapatite and Fluorapatite in Conservative Dentistry and Oral Implantology—A Review

2019

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“…HA is the main inorganic component of bones and teeth of vertebrates. Bases on the stability and flexibility of the HA crystal structure, calcium ions on HA can be replaced with divalent metal cation such as iron [7], magnesium [8], silver [9], cobalt [10] etc. Due to cobalt ion being a hypoxia-mimicking agent, it can activate the hypoxia inducible factor-1 (HIF-1α) in mesenchymal stem cells and subsequently activate HIF-1α target genes including vascular endothelial growth factor (VEGF) erythropoietin (EPO) [11,12,13,14].…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study on the Direct and Pulsed Current Electrodeposition of Cobalt-Substituted Hydroxyapatite for Magnetic Resonance Imaging Application

et al. 2018

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Hydroxyapatite has excellent biocompatibility and osteo-conductivity and, as the main inorganic component of human bones and teeth, is commonly used for bone repair. Its original characteristics can be changed by metal ion substitution. Cobalt ions can act as hypoxia-inducible factors and accelerate bone repair. At the same time, cobalt has paramagnetic properties and is often used in the study of medical imaging and target drugs. Through the introduction of cobalt ions, the unique hydroxyapatite has better biological activity and positioning of medical images. Herein, cobalt-substituted hydroxyapatite (CoHA) was synthesized on the surface of a titanium plate by electrochemical deposition and changes in the power output mode to explore the impact on CoHA. Electrochemical deposition with a pulse current significantly improved the productivity and uniformity of CoHA on the surface of titanium. CoHA show paramagnetic characteristics by a superconducting quantum interference device (SQUID). Resulting smaller particle size and circular morphology improves the magnetic strength of CoHA. Magnetic resonance imaging (MRI) of CoHA showed significant image contrast effect at low concentrations. The calculated particle relaxation rate was higher than other common MRI contrast agents. Biocompatibility of CoHA powder was evaluated using the human osteosarcoma cell line (MG63) which confirmed that CoHA is not cytotoxic and can promote cell growth and extracellular matrix mineralization. With the release of cobalt ions, CoHA was found to be significantly good in repression E. coli indicating about than 95% reduction in bacterial growth. The as-synthesized CoHA has a low degree of crystallinity, highly sensitive image contrast effect, and good bioactivity, and may have potential applications in bone repair and MRI.

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“…The similarity of the effective ionic radius of silver ions (CN 7 —1.22 Å) to calcium ions (CN 9 —1.18 Å, CN 7 —1.06 Å) gives a possibility to substitute calcium ions with silver ions. 30 , 34 …”

Section: Resultsmentioning

confidence: 99%

Preparation of a New Biocomposite Designed for Cartilage Grafting with Antibiofilm Activity

et al. 2020

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New polymer–inorganic composites with antibiofilm features based on the granulated poly(tetrafluoroethylene) (PTFE) and apatite materials were obtained using a standard hydraulic press. The study was performed in hydroxy- and fluorapatites doped with different amounts of silver ions and followed by heat treatment at 600 °C. The structural, morphological, and physicochemical properties were determined by X-ray powder diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy-energy-dispersive spectrometry (SEM-EDS), and transition electron microscopy (TEM). The antibacterial properties of the obtained materials were evaluated against Gram-negative pathogens such as Pseudomonas aeruginosa , Klebsiella pneumoniae , and Escherichia coli as well as against Gram-positive bacteria Staphylococcus epidermidis . The cytotoxicity assessment was carried out on the red blood cells (RBC) as a cell model for in vitro study. Moreover, the biofilm formation on the biocomposite surface was studied using confocal laser scanning microscopy (CLSM).

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Synthesis, structural characterisation and antibacterial activity of Ag+-doped fluorapatite nanomaterials prepared by neutralization method

Cited by 43 publications

References 55 publications

Hydroxyapatite and Fluorapatite in Conservative Dentistry and Oral Implantology—A Review

Hydroxyapatite and Fluorapatite in Conservative Dentistry and Oral Implantology—A Review

A Comparative Study on the Direct and Pulsed Current Electrodeposition of Cobalt-Substituted Hydroxyapatite for Magnetic Resonance Imaging Application

Preparation of a New Biocomposite Designed for Cartilage Grafting with Antibiofilm Activity

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