Synthesis, spectroscopic characterization, DNA cleavage and antibacterial studies of a novel tridentate Schiff base and some lanthanide(III) complexes

Mohanan, K.; Aswathy, R.; Nitha, L.P.; Mathews, Niecy Elsa; Kumari, B. Sindhu

doi:10.1016/s1002-0721(14)60081-8

Cited by 31 publications

(12 citation statements)

References 35 publications

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“…The IR spectrum of the free ligand is compared with the spectra of the complexes. The IR spectrum of the free between phenolic hydrogen and azomethine nitrogen atoms [35,36,37]. Further, the appearance of the OH band around 3465-3395 cm -1 in the spectra of the complexes with an increase in intensity indicates that the hydroxyl oxygen is coordinated to the M(II) ion without proton displacement [38].…”

Section: Ir and Electronic Spectra For The Investigated Compoundsmentioning

confidence: 99%

Synthesis, structure elucidation, biological screening, molecular modeling and DNA binding of some Cu(II) chelates incorporating imines derived from amino acids

Abdel‐Rahman

Abu‐Dief

Ismael

et al. 2016

Journal of Molecular Structure

130

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Section: Ir and Electronic Spectra For The Investigated Compoundsmentioning

confidence: 99%

Synthesis, structure elucidation, biological screening, molecular modeling and DNA binding of some Cu(II) chelates incorporating imines derived from amino acids

Abdel‐Rahman

Abu‐Dief

Ismael

et al. 2016

Journal of Molecular Structure

130

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“…On complexation the fluorescence intensity increases. The introduction of the metal ion to the Schiff base enlarges the π‐conjugated system of the complex and enhances the luminescent intensity of the complex . The fluorescent intensity enhancement may be due to the coordination of free ligand to metal ions, thus reducing the loss of energy via radiationless thermal vibrations of the intra‐ligand excited states, and to an increase in the rigidity of the ligand .…”

Section: Resultsmentioning

confidence: 99%

“…From the XRD pattern of the copper(II) complex, it is observed that the crystallinity has been lost after complexation. The average crystalline size of the ligand was calculated using the Scherrer formula, d xrd = 0.9 λ / β cos θ and was found to be 32 nm …”

Section: Resultsmentioning

confidence: 99%

Synthesis and Biological Evaluation of some 3d Metal Complexes with a Novel Heterocyclic Schiff Base

Thomas

Mohanan

2017

J Chinese Chemical Soc

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A heterocyclic Schiff base was prepared by condensing 3‐acetylcoumarin with 2‐amino‐3‐carboxyethyl‐4,5,6,7‐tetrahydrobenzo[b]thiophene. Such Schiff bases derived from two different heterocyclic moieties are rare and expected to have properties surpassing those of either of the parent compounds in effectiveness of complex formation and biological activities. This ligand formed a series of complexes with manganese(II), cobalt(II), nickel(II), copper(II), and zinc(II) ions. The ligand and the metal complexes were characterized by various physicochemical and spectral studies. These included elemental analysis, molar conductance, magnetic susceptibility, as well as UV–vis, IR, 1H NMR, 13C NMR, and ESR spectral studies. The ESR spectral data adequately supported the covalent nature of the metal–ligand bonds. The ligand possessed a hexagonal crystal structure, but on complexation the crystallinity was lost. The fluorescence spectra of the ligand and its metal complexes in DMSO were also recorded. The ligand and the metal complexes were screened for their antimicrobial activities, and it was observed that the metal complexes are more active than the ligand. The α‐amylase inhibitory activity and the DNA cleavage activity of the ligand and the metal complexes were also examined. in vitro antitumor activity of the copper(II) complex was assayed against human cervical carcinoma cells (HeLa cell line), showing that the complex exhibited promising antitumor activity on the HeLa cell line.

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“…The fluorescence emission intensity of Schiff base increase upon complex formation with metal ions in the order: nickel(II) < zinc(II) ~ copper (II) < cobalt (II). The introduction of metal ion to the Schiff base enlarges the π-conjugated system of the complex and enhances the luminescent intensity of the complex 29 . Rigidity of the ligand increases upon complexation.…”

Section: Fig5 Epr Spectrum Of the Copper(ii) Complexmentioning

confidence: 99%

Synthesis and Spectroscopic Characterization of Some Transition Metal Complexes of Schiff Base 3-(2-hydroxyphenylimino) methyl-4,5,-dimethyl-1-phenylpyrazol-3-in-2-one

Thomas¹,

Philip²,

Mohanan³

2017

Orient. J. Chem

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A novel potentially tridentate Schiff base has been prepared by condensing antipyrine-4-carboxaldehyde with 2-aminophenol. This ligand formed a series of complexes with cobalt(II), nickel(II), copper(II) and zinc(II) ions. The ligand and the metal complexes were characterized through various physicochemical and spectral studies. These studies include elemental analysis, molar conductance, magnetic susceptibility, UV-Vis, IR, 1 H NMR, mass and ESR spectral studies. The ESR spectral data revealed that the metal-ligand bonds have considerable covalent characters. The XRD profile of the ligand and the cobalt(II) complex indicated a hexagonal crystal structure. The fluorescence spectra of the ligand and its metal complexes in DMSO were also recorded. The copper(II) metal complex was subjected to thermal decomposition study.

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Synthesis, spectroscopic characterization, DNA cleavage and antibacterial studies of a novel tridentate Schiff base and some lanthanide(III) complexes

Cited by 31 publications

References 35 publications

Synthesis, structure elucidation, biological screening, molecular modeling and DNA binding of some Cu(II) chelates incorporating imines derived from amino acids

Synthesis, structure elucidation, biological screening, molecular modeling and DNA binding of some Cu(II) chelates incorporating imines derived from amino acids

Synthesis and Biological Evaluation of some 3d Metal Complexes with a Novel Heterocyclic Schiff Base

Synthesis and Spectroscopic Characterization of Some Transition Metal Complexes of Schiff Base 3-(2-hydroxyphenylimino) methyl-4,5,-dimethyl-1-phenylpyrazol-3-in-2-one

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