Synthesis, Spectral Properties and Crystal Structure of Calcium and Strontium Complexes of 1,10‐Phenanthroline

Neykov, Mihail; Almsick, Tobias van; Dimitrov, Georgi

doi:10.1002/zaac.200500534

Cited by 11 publications

(9 citation statements)

References 19 publications

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“…The carbonyl peaks fall in the range 1590–1650 cm –1 , in good agreement with literature examples . The peaks in the range 1512–1515 cm –1 reflect the presence of the heterocyclic phen C–N stretching in the complexes …”

Section: Resultssupporting

confidence: 89%

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Sodium, Potassium, and Lithium Complexes of Phenanthroline and Diclofenac: First Report on Anticancer Studies

Shah

Khan³

et al. 2019

ACS Omega

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Diclofenac or 2-[(2′,6′-dichlorophenyl)amino]phenyl}acetic acid (dcf) is a nonsteroidal anti-inflammatory drug, and 1,10-phenanthroline (phen) is a well-known enzyme inhibitor. In this study, three new alkali metal complexes (1–3) containing both phen and dcf were prepared, and their structures were characterized by a variety of analytical techniques including infrared and UV–vis spectroscopy, 1H NMR and 13C NMR elemental analysis, mass spectrometry, and single-crystal X-ray diffraction analysis. In these complexes, phen binds via a N,N′-chelate pocket, while the monoanionic dcf—ligand remains either uncoordinated (in the case of 1 and 3) or coordinated in a bidentate fashion (in the case of 2). All three complexes crystallize in the triclinic space group P-1. [Na2(phen)2 (H2O)4][dcf]2 (1) is a dinuclear sodium complex, where two crystallographically identical Na+ cations adopt a distorted five-coordinate spherical square-pyramidal geometry, with a [N2O3] donor set. [K2(phen)2(dcf)2(H2O)4] (2) is also a dinuclear complex where the crystallographically unique K+ cation adopts a distorted seven-coordinate geometry comprising a [N2O5] donor set. [Li(phen)(H2O)2][dcf] (3) is a mononuclear lithium complex where the Li+ cation adopts a four-coordinate distorted tetrahedral geometry comprising a [N2O2] donor set. The complexes were evaluated for their anticancer activity against lung and oral cancer cell lines as well as for their antibacterial potential. The prepared complexes displayed very good antibacterial and anticancer activities with an excellent bioavailability.

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Section: Resultssupporting

confidence: 89%

“…36 The peaks in the range 1512–1515 cm –1 reflect the presence of the heterocyclic phen C–N stretching in the complexes. 37…”

Section: Resultsmentioning

confidence: 99%

Sodium, Potassium, and Lithium Complexes of Phenanthroline and Diclofenac: First Report on Anticancer Studies

Shah

Khan³

et al. 2019

ACS Omega

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“…The carbonyl peaks fall in the range 1661-1665 cm À1 , in good agreement with literature examples (Deacon, 1980). The peaks in the range 1514-1520 cm À1 reflect the presence of the heterocyclic phen C N stretching in the complexes (Neykov et al, 2006).…”

Section: Ft-irsupporting

confidence: 88%

Crystal structure, shape analysis and bioactivity of new Li^I, Na^I and Mg^II complexes with 1,10-phenanthroline and 2-(3,4-dichlorophenyl)acetic acid

Shah

Ullah

et al. 2019

Acta Crystallogr C Struct Chem

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Reactions of 1,10-phenanthroline (phen) and 2-(3,4-dichlorophenyl)acetic acid (dcaH) with Mn (CO3) (M = LiI, NaI and MgII; n = 1 and 2) in MeOH yield the mononuclear lithium complex aqua[2-(3,4-dichlorophenyl)acetato-κO](1,10-phenanthroline-κ2 N,N′)lithium(I), [Li(C8H5Cl2O2)(C12H8N2)(H2O)] or [Li(dca)(phen)(H2O)] (1), the dinuclear sodium complex di-μ-aqua-bis{[2-(3,4-dichlorophenyl)acetato-κO](1,10-phenanthroline-κ2 N,N′)sodium(I)}, [Na2(C8H5Cl2O2)2(C12H8N2)2(H2O)2] or [Na2(dca)2(phen)2(H2O)2] (2), and the one-dimensional chain magnesium complex catena-poly[[[diaqua(1,10-phenanthroline-κ2 N,N′)magnesium]-μ-2-(3,4-dichlorophenyl)acetato-κ2 O:O′] 2-(3,4-dichlorophenyl)acetate monohydrate], {[Mg(C8H5Cl2O2)(C12H8N2)(H2O)2](C8H5Cl2O2)·H2O} n or {[Mg(dca)(phen)(H2O)2](dca)·H2O} n (3). In these complexes, phen binds via an N,N′-chelate pocket, while the deprotonated dca− ligands coordinate either in a monodentate (in 1 and 2) or bidentate (in 3) fashion. The remaining coordination sites around the metal ions are occupied by water molecules in all three complexes. Complex 1 crystallizes in the triclinic space group P\overline{1} with one molecule in the asymmetric unit. The Li+ ion adopts a four-coordinated distorted seesaw geometry comprising an [N2O2] donor set. Complex 2 crystallizes in the triclinic space group P\overline{1} with half a molecule in the asymmetric unit, in which the Na+ ion adopts a five-coordinated distorted spherical square-pyramidal geometry, with an [N2O3] donor set. Complex 3 crystallizes in the orthorhombic space group P212121, with one Mg2+ ion, one phen ligand, two dca− ligands and three water molecules in the asymmetric unit. Both dcaH ligands are deprotonated, however, one dca− anion is not coordinated, whereas the second dca− anion coordinates in a bidentate fashion bridging two Mg2+ ions, resulting in a one-dimensional chain structure for 3. The Mg2+ ion adopts a distorted octahedral geometry, with an [N2O4] donor set. Complexes 1–3 were evaluated against urease and α-glucosidase enzymes for their inhibition potential and were found to be inactive.

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“…The coordination chemistry and biochemical binding mechanisms of a magnesium ion Mg 2? are of special interest due to its significant role in biological processes [6][7][8][9]. For instance, at molecular level, these metal ions participate in homeostasis and are important in electrolyte pathophysiology [10].…”

Section: Introductionmentioning

confidence: 99%

Magnesium sulphate complexes with hexamethylenetetramine and 1,10-phenanthroline

Sierański

Kruszyński

2011

J Therm Anal Calorim

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Synthesis, Spectral Properties and Crystal Structure of Calcium and Strontium Complexes of 1,10‐Phenanthroline

Cited by 11 publications

References 19 publications

Sodium, Potassium, and Lithium Complexes of Phenanthroline and Diclofenac: First Report on Anticancer Studies

Sodium, Potassium, and Lithium Complexes of Phenanthroline and Diclofenac: First Report on Anticancer Studies

Crystal structure, shape analysis and bioactivity of new Li^I, Na^I and Mg^II complexes with 1,10-phenanthroline and 2-(3,4-dichlorophenyl)acetic acid

Magnesium sulphate complexes with hexamethylenetetramine and 1,10-phenanthroline

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Synthesis, Spectral Properties and Crystal Structure of Calcium and Strontium Complexes of 1,10‐Phenanthroline

Cited by 11 publications

References 19 publications

Sodium, Potassium, and Lithium Complexes of Phenanthroline and Diclofenac: First Report on Anticancer Studies

Sodium, Potassium, and Lithium Complexes of Phenanthroline and Diclofenac: First Report on Anticancer Studies

Crystal structure, shape analysis and bioactivity of new LiI, NaI and MgII complexes with 1,10-phenanthroline and 2-(3,4-dichlorophenyl)acetic acid

Magnesium sulphate complexes with hexamethylenetetramine and 1,10-phenanthroline

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Crystal structure, shape analysis and bioactivity of new Li^I, Na^I and Mg^II complexes with 1,10-phenanthroline and 2-(3,4-dichlorophenyl)acetic acid