Synthesis, properties and biomedical applications of carbon-based quantum dots: An updated review

Namdari, Pooria; Negahdari, Babak; Eatemadi, Ali

doi:10.1016/j.biopha.2016.12.108

Cited by 436 publications

(221 citation statements)

References 127 publications

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“…Employing a one-pot synthesis strategy, the obtained citrate-based CDs typically had polydispersed structures, including small molecules, oligomers, polymer chains, polymer clusters and carbon cores. [13, 14, 25, 26] Song et al systematically studied the components of CDs synthesized from CA and ethylenediamine (EDA). [25] They separated the CDs reacted at 140 °C by column chromatography on silica, and obtained 5 batches of fluorescent components.…”

Section: Citrate-based Carbon Dots (Cds)mentioning

confidence: 99%

“…Although current understanding of the structural properties and fluorescence mechanisms of CDs remain inadequate, researchers have proposed a number of hypotheses to explain the fluorescence mechanism of CDs. [12, 13, 14, 65, 66] In the following section, we will discuss the fluorescence mechanisms of CDs, with focus on their three most important states (the molecule state, the carbon core state, and the surface state).…”

Section: Citrate-based Carbon Dots (Cds)mentioning

confidence: 99%

“…[11] In the past decade, fluorescent carbon dots (CDs) have been widely developed through pyrolysis of CA with or without amine based molecules. [12, 13–15] These citrate-based CDs, when compared with traditional fluorescent agents, possess numerous advantages, including biocompatibility, straightforward synthesis, and strong fluorescence with adjustable emission spectra (from blue to NIR). [16–20] Researchers have proposed that the fluorescence performance of citrate-based CDs can be attributed to both their carbon cores and small molecular fluorophores.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Citrate‐Based Fluorescent Biomaterials

Shan

Hsieh

Bai

et al. 2018

Adv Healthcare Materials

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Fluorescence imaging has emerged as a promising technique for monitoring and assessing various biologically relevant species in cells and organisms, driving the demand for effective fluorescent agents with good biocompatibility and high fluorescence performance. However, traditional fluorescent agents, such as quantum dots (QDs) and organic dyes, either suffer from toxicity concerns or poor fluorescence performance (e.g., low photobleaching-resistance). In this regard, citrate-based fluorescent biomaterials, which are synthesized from the natural and biocompatible precursor of citric acid (CA), have become competitive alternatives for fluorescence imaging owing to their biocompatibility, cost effectiveness, straightforward synthetic routes, flexible designability, as well as strong fluorescence with adjustable excitation/emission wavelengths. Accordingly, numerous citrate-based biomaterials, including carbon dots (CDs), biodegradable photoluminescent polymers (BPLPs), and small molecular fluorophores, have been developed and researched in the past few decades. This review discusses recent progress in the research and development of citrate-based fluorescent materials with emphasis on their design and synthesis considerations, material properties, fluorescence properties and mechanisms, as well as biomedical applications. It is expected that this review will provide an insightful discussion on the citrate-based fluorescent biomaterials, and lead to innovations for the next generation of fluorescent biomaterials and fluorescence-based biomedical technology.

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Section: Citrate-based Carbon Dots (Cds)mentioning

confidence: 99%

Section: Citrate-based Carbon Dots (Cds)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Citrate‐Based Fluorescent Biomaterials

Shan

Hsieh

Bai

et al. 2018

Adv Healthcare Materials

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“…Moreover, C-dots have been widely recognized with their antibacterial effects. [17][18][19][20][21][22][23] In this work, we attempted to identify the antibacterial effect potentially brought by date pit-derived C-dots, and explore the mechanism. Finally, we will estimate the potential of date pit-derived C-dots-mediated DNA damage and repair pathways, cell proliferation signaling using mutation or cancer cell lines.…”

Section: Introductionmentioning

confidence: 99%

Date Pit Carbon Dots Induce Acidic Inhibition of Peroxidase and Disrupt DNA Repair in Antibacteria Resistance

et al. 2019

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Carbon nanodots (C‐dots) are emerging as a new type of promising agent in anticancer, imaging, and new energy. Reports as well as the previous research indicate that certain C‐dots can enhance targeted cancer therapy. However, in‐depth mechanisms for such anticancer effect remain unclear. In this work, treatment provided by the date pit‐derived C‐dots, exhibits significant DNA damage; Annexin V/7‐AAD‐mediated apoptosis, and G2/M cell cycle arrest in prostate cancer cells. The application of C‐dots to the cell generally leads to acidulation of the cell medium, cooperated with membrane compact. The date pit‐derived C‐dots are observed inhibiting the horseradish peroxidase. Moreover, the C‐dots disrupt likely through nucleotide excision DNA repair at low dose during DNA ligation step suggesting the antimicrobial effect and targeting Pim‐1, EGFR, mTOR, and DNA damage pathways in cancer cells. For the first time the detailed and novel mechanisms underlying the C‐dots, derived from the date‐pit, as an efficient, low‐cost, and green nanomaterial are reveled for cancer therapy and anti‐infection.

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“…As an innovative fluorescence nanomaterial, CDs have palmary photoluminescence, chemical inertness, and biocompatibility [8,9]. Based on the previous studies, CDs would cause no abnormality, damage, and toxicity to tissues, organs, and even genes.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Fluorescent Carbon Dots by Gastrointestinal Fluid Treatment of Mongolia Har Gabur

Wang

Zhang

et al. 2017

Journal of Nanomaterials

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Har Gabur is the carbide obtained from pig manure by burning. The fluorescent carbon dots (CDs) of Har Gabur were successfully synthesized through simulating the digestion process of human gastrointestinal tract. Transmission Electron Microscope (TEM) analysis showed that the average size of the prepared Har Gabur CDs was 4 nm, with good solubility in water and strong fluorescence under UV irradiation. The X-ray and Raman results showed that the Har Gabur CDs were mainly composed of oxygen "O" and carbon "C" elements, in the forms of "C=O" and "C-O." The bond energy results showed that the nitrogen "N" atom presented as "C-N" form, which indicated that Har Gabur CDs also contain "N." In photobleaching assay, Har Gabur CDs showed excellent light stability compared with ordinary organic dye, fluorescein, and Rhodamine B. The fluorescence intensity of Har Gabur CDs was fairly stable within a wide pH range of 3-10. When L-lysine and L-cysteine were applied for the passivation stage, the relative quantum yields were improved by 1.53 and 3.68 times, respectively. Finally, the fluorescence properties of Har Gabur CDs were tested in cells and zebrafish, illustrating that Har Gabur CD has potential in the application of biological labeling and imaging.

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Synthesis, properties and biomedical applications of carbon-based quantum dots: An updated review

Cited by 436 publications

References 127 publications

Citrate‐Based Fluorescent Biomaterials

Citrate‐Based Fluorescent Biomaterials

Date Pit Carbon Dots Induce Acidic Inhibition of Peroxidase and Disrupt DNA Repair in Antibacteria Resistance

Synthesis of Fluorescent Carbon Dots by Gastrointestinal Fluid Treatment of Mongolia Har Gabur

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