Synthesis, physicochemical and biological studies of a ternary Co(II) complex with sulfaquinoxaline and 2,2′-bipyrimidine as ligands

Crystal structure, Hirshfeld surface analysis, spectroscopic and biological studies on sulfamethazine and sulfaquinoxaline ternary complexes with 2,2′-biquinoline

“…Sulfonamide compounds are recognized for their biological properties [1][2][3][4][5][6] and their different coordination modes 5 . A wide variety of metal complexes with N-sulfonamides derivatives has also been studied for their polymer stabilization capacity 2 , magnetic behavior [7][8][9][10] , electrochemical properties 8,9,11 and luminescent emission 12,13 .…”

“…Some complexes with sulfaquinoxaline (SQO) or sulfamethazine (SMT) as ligands (see Scheme 1) have been reported as effective chemotherapeutic agents. In the case of SQO, a polymeric Cd(II) complex 12 and some monomeric ternary Co(II) 3 and Zn(II) 13 complexes have been described. On the other hand, some sulfamethazine complexes have been described as monomeric, dimeric and polymeric M(II) derivatives 5,[9][10][11][14][15][16] .…”

“…materials, pharmaceuticals). In the case of sulfonamide metal complexes, inter and intramolecular hydrogen bonding, π•••π, and C-H•••π interactions have a great influence on the crystal lattice stabilization 1,3,5,8,17 . The Hirshfeld surface analysis is a powerful tool for visualizing and quantifying the contribution of such intermolecular interactions to supramolecular assemblies [18][19][20] .…”

“…As part of our ongoing research on the study of the structural and physicochemical properties of sulfonamides metal complexes 3,7,21,22 , we have previously reported the study in different models of biological systems in a ternary cobalt complex with sulfaquinoxaline and 2,2`-Bypirimidine as ligand 3 . Our goal herein is to extend these studies to other auxiliary ligands and metals with eventual biological properties.…”

Single‐Ion Magnets Based on Mononuclear Cobalt(II) Complexes with Sulfadiazine

“…We have previously reported the structure and physicochemical characterization of some metal complexes of sulfonamides with different metals . Recently, we have studied the aquatic toxicity, antimicrobial activities, and cytotoxicity of a cobalt complex with sulfaquinoxaline and 2,2′‐bipyrimidine as ligands in osteoblast‐like cells . Other similar complexes with sulfadiazine (SDZ) and sulfamethazine have also been reported…”