Synthesis of Xanthones by Palladium‐Catalyzed Tandem Carbonylation/C–H Activation via 2‐Iodo Diaryl Ethers

Abstract

The ring closure of 2‐iodo diaryl ether in the presence of a palladium catalyst to xanthone under carbon monoxide atmosphere is studied. A series of xanthones could be successfully obtained through this protocol, with Pd(OAc)2 as the catalyst, P(Cy)3 as ligand, PivONa.H2O as base, and PivOH and tetrabutylamonium bromide as additives in DMSO, in moderate to good yields.

Recent Development in Palladium-Catalyzed Domino Reactions: Access to Materials and Biologically Important Carbo- and Heterocycles

“…A series of products could be successfully obtained through this protocol, with Pd(OAc) 2 as catalyst, P(Cy) 3 as ligand, PivONa•H 2 O as base, and PivOH and tetrabutylammonium bromide as additives in DMSO, in moderate to good yields (Scheme 35). 56 Apart from their presence in many natural products, other bioactive heterocyclic xanthones are very useful as organic markers in medicine.…”