Synthetic approaches to biologically active xanthones: an update

Ramakrishnan, Shurutishria; Paramewaran, Sakunthala; Nasir, Nadiah Mad

doi:10.1007/s11696-020-01320-0

Cited by 10 publications

(5 citation statements)

References 75 publications

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“…In general, the reactions proceeded smoothly within two hours with modest to high conversions, but isolation of these known compounds, 26 , 27 , 28 , 29 , 30 in the high yields often reported, proved difficult; however, up to 30% isolated yields were achieved, in-line with the experiences of others when making these, and similar, compounds. 24 Nevertheless, the reactions could be carried out on a gram scale providing enough material for characterisation and biological evaluation.…”

supporting

confidence: 59%

Hydroxy-xanthones as promising antiviral agents: Synthesis and biological evaluation against human coronavirus OC43

Dean

Cooper

Shivkumar

et al. 2023

Bioorganic & Medicinal Chemistry Letters

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supporting

confidence: 59%

Hydroxy-xanthones as promising antiviral agents: Synthesis and biological evaluation against human coronavirus OC43

Dean

Cooper

Shivkumar

et al. 2023

Bioorganic & Medicinal Chemistry Letters

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“…These compounds are attracting a considerable research interest as they (e.g. various hydroxy- and methoxy-analogues) were reported to possess a wide range of biological activities, including anticancer, antimalarial, antimicrobial, anti-HIV, anticonvulsant, anticholinesterase, antioxidant, anti-inflammatory effect (Miladiyah et al 2018 ; Ramakrishnan et al 2021 ). It was also found out that xanthones may interfere with several enzymes, including α-glucosidase, acyl-CoA:cholesterol acyltransferase, aromatase intestinal P-glycoprotein, miRNA, protein kinase C, topoisomerase, and xanthine oxidase.…”

Section: Resultsmentioning

confidence: 99%

Garcinia kola: a critical review on chemistry and pharmacology of an important West African medicinal plant

et al. 2023

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Garcinia kola Heckel (Clusiaceae) is a tree indigenous to West and Central Africa. All plant parts, but especially the seeds, are of value in local folklore medicine. Garcinia kola is used in treatment of numerous diseases, including gastric disorders, bronchial diseases, fever, malaria and is used to induce a stimulating and aphrodisiac effect. The plant is now attracting considerable interest as a possible source of pharmaceutically important drugs. Several different classes of compounds such as biflavonoids, benzophenones, benzofurans, benzopyran, vitamin E derivatives, xanthones, and phytosterols, have been isolated from G. kola, of which many appears to be found only in this species, such as garcinianin (found in seeds and roots), kolanone (fruit pulp, seeds, roots), gakolanone (stem bark), garcinoic acid, garcinal (both in seeds), garcifuran A and B, and garcipyran (all in roots). They showed a wide range of pharmacological activities (e.g. analgesic, anticancer, antidiabetic, anti-inflammatory, antimalarial, antimicrobial, hepatoprotective and neuroprotective effects), though this has only been confirmed in animal models. Kolaviron is the most studied compound and is perceived by many studies as the active principle of G. kola. However, its research is associated with significant flaws (e.g. too high doses tested, inappropriate positive control). Garcinol has been tested under better conditions and is perhaps showing more promising results and should attract deeper research interest (especially in the area of anticancer, antimicrobial, and neuroprotective activity). Human clinical trials and mechanism-of-action studies must be carried out to verify whether any of the compounds present in G. kola may be used as a lead in the drug development.

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“…At present, nearly 1000 naturally occurring xanthone derivatives are known. Each has different substituents at different positions, ultimately leading to a large variety of pharmacological activities [18,19]. The multitude of biological activities found for xanthone derivatives include α-glucosidase inhibition, anti-cancer, anti-Alzheimer, anticonvulsant, anxiolytic, antidepressant, analgesic, antibacterial, antioxidant, and anti-inflammatory activities [20][21][22][23][24][25].…”

Section: Xanthone Derivatives and Their Vascular Activitymentioning

confidence: 99%

Xanthone Derivatives and Their Potential Usage in the Treatment of Telangiectasia and Rosacea

Brezdeń,

Waszkielewicz

2024

Applied Sciences

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Xanthone derivatives, a class of natural compounds abundantly found in plants such as mangosteen (Garcinia mangostana) and certain herbs, have garnered substantial interest due to their diverse pharmacological properties, including antioxidant, anti-inflammatory, and anti-cancer activities. Recent investigations have unveiled their potential as modulators of enzymatic activity, prompting exploration into their effects on hyaluronidase-mediated hyaluronic acid (HA) degradation, and their effects in topical treatment of telangiectasia and rosacea. Telangiectasia and rosacea are common dermatological conditions characterized by chronic skin inflammation, vascular abnormalities, and visible blood vessels, resulting in significant cosmetic concerns and impaired quality of life for affected individuals. This review aims to provide a comprehensive overview of the current understanding regarding the interplay between the mechanisms of action by which xanthone derivatives exert their therapeutic effects, including the inhibition of pro-inflammatory cytokines, modulation of oxidative stress pathways, and regulation of vascular endothelial growth factors. Furthermore, we will discuss the implications of harnessing xanthone derivatives as therapeutic agents for mitigating vascular dysfunction and its associated pathologies, thereby offering insights into future research directions and therapeutic strategies in the field of vascular biology.

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Synthetic approaches to biologically active xanthones: an update

Cited by 10 publications

References 75 publications

Hydroxy-xanthones as promising antiviral agents: Synthesis and biological evaluation against human coronavirus OC43

Hydroxy-xanthones as promising antiviral agents: Synthesis and biological evaluation against human coronavirus OC43

Garcinia kola: a critical review on chemistry and pharmacology of an important West African medicinal plant

Xanthone Derivatives and Their Potential Usage in the Treatment of Telangiectasia and Rosacea

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