Recent Development in Palladium-Catalyzed Domino Reactions: Access to Materials and Biologically Important Carbo- and Heterocycles

Abstract

The chemistry of palladium complexes has no limits. Many domino processes (even multicomponent) are continuously appearing in the literature. Carbocyclic and heterocyclic molecules are efficiently prepared under the atom economy principle using the smallest amount of the catalyst. The importance of the applications in many scientific areas of all these cyclic skeletons made this general methodology much more attractive.

4-Amino-1,2,4-triazoles-3-thiones and 1,3,4-oxadiazoles-2-thiones·palladium(II) recoverable complexes as catalysts in the sustainable Suzuki-Miyaura cross-coupling reaction

“…Here, the alkene acted as internal relay system, which inhibited the β-hydride elimination of the intermediate organometallic species, after the 5-exo-trig-cyclization step. 49,50 The resulting palladium-Csp 3 intermediate finally underwent the expected Suzuki-Miyaura cross-coupling with p-tolylboronic acid. This sequential double Csp 2 -Csp 3 formation occurred in the presence of 1 mol% of the catalyst in 81% yield (Scheme 2).…”

Cascade polymerizations: recent developments in the formation of polymer repeat units by cascade reactions

“…Transition metal-mediated cascade reactions have been extensively explored in small molecule and natural product synthesis. [43][44][45][46][47] Several of these reactions have been successfully applied to cascade polymerizations. Double cyclization polymerizations, [48][49][50] and various combinations of cyclopolymerization with chain walking (typically with Pd or Ni catalysts) [51][52][53] have already been extensively reviewed in the literature.…”

Enzyme-Graphene Nanometal biohybrid Architectures as Highly Efficient Multifunctional Catalysts for Cascade Reactions

“…[24][25] In this way, successful applicability of the metal nanoparticles in domino and cascade synthesis have been described. [26][27][28][29] Recently, a third approach focusing on the development of chemoenzymatic cascade processes has been the combination of metal nanoparticles and enzymes. A very fancy approach combining metal nanoparticles with enzymes in the same solid material has been described for chemoenzymatic cascade processes.…”