Synthesis of Some New Heterocycles Derived from Novel 2‐(1,3‐Dioxisoindolin‐2‐yl)Benzoyl Isothiocyanate

Abstract

Novel 2‐(1,3‐Dioxisoindolin‐2‐yl)benzoyl isothiocyanate was prepared and underwent addition–cyclization reactions with some nucleophilic reagents. Simultaneous or subsequent cyclization of the obtained adducts gave a diverse range of differently sized heterocycles and thioureas. The structures of the synthesized compounds were confirmed by microanalytical and spectral data.

Nano nickel [1,2,4]‐triazole‐3‐thiones complex: Design, sonochemical synthesis, and antimicrobial evaluation

“…Nowadays, we perceive that the "solvent-drop grinding" methodology may afford a fruitful means of controlling the polymorphic outcome of a co-crystallization. [13,14] 1,2,4-Triazoles chemistry are fascinating heterocycles and their derivatives specially they belong to isothiocyanates (ITCs) [15][16][17][18][19][20][21] class. Also, they possess significant pharmacological activities such as antitumor, [22] antifungal, [23] antiviral, [24] stimulants sedatives, [25][26] anti-inflammatory, [27] and antimycotic agents, [28] for example, 1 fluconazole, 2 voriconazole, 3 Fluconazole, 4 itraconazole, 5 Triazolam, 6 Alprazolam, and 7 Etizolam (Figure 1).…”

Antiproliferative Activity of Some Newly Synthesized Substituted Pyridine Candidates Using 4-(Aaryl)-6-(naphthalen-1-yl)-2-oxo-1,2-dihydropyridine-3-carbonitrile as Synthon

“…In an attempt to prepare certain novel heterocycles, − determine their insecticidal effectiveness, − and evaluate their pharmaceutical significance, − compounds 4a , b were allowed to react with phenylisothiocyanate to yield 4-(4-chlorophenyl)-3-cyano-6-(naphthalen-1-yl)-2-oxo- N -phenyl-pyridine-1­(2 H )-carbothioamide and 3-cyano-6-(naphthalen-1-yl)-2-oxo- N -phenyl-4-(thiophen-2-yl)­pyridine-1­(2 H )-carbothioamide ( 5a , b ). Their structures were established from elemental and spectral analyses.…”

Cytotoxic Effects of Newly Synthesized Heterocyclic Candidates Containing Nicotinonitrile and Pyrazole Moieties on Hepatocellular and Cervical Carcinomas

“…The nicotinonitriles were obtained by two different ways, from the reaction of chalcone with ethylcyanoacetate, ammonium acetate and drops of piperidine as a base and from one pot four components reaction of methylketone, aldehyde, ethylcyanoacetate, ammonium acetate and drops of piperidine as a base [15]. In prolongation of our work in the synthesis of heterocyclic compounds and evaluation of their medicinal importance [16,17,18,19,20,21,22,23,24,25,26,27] and based on the literature survey about the pharmacological and medicinal importance of pyrazoles and nicotinonitriles, we have devoted our efforts to design and synthesize novel heterocyclic compounds containing pyrazol and nicotine-nitrile moieties, 4-(3-(4-fluorophenyl)-1-phenyl-1 H -pyrazol-4-yl)-2-hydroxy-6-(naphthalen-1-yl)-nicotinenitrile 8 has been obtained by reacting of 1-acetylnaphthalene ( A ), 3-(4-fluorophenyl)-1-phenyl-1 H -pyrazole-4-carbaldehyde ( B ), ethyl 2-cyanoacetate, ammonium acetate and piperidine (Scheme 1).…”