Synthesis of silver nanoparticles from Melia dubia leaf extract and their in vitro anticancer activity

Kathiravan, V.; Ravi, S.; Srinivasan, A. R.

doi:10.1016/j.saa.2014.03.107

Cited by 210 publications

(91 citation statements)

References 36 publications

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“…26,27 Lung cancer has been reported to be one of the most important causes of death worldwide. 28 In this study, A549 human lung cancer cells were used as a model to determine the cytotoxicity of D-AgNPs and D-AuNPs, as well as their synergetic effects with CK.…”

Section: In Vitro Cytotoxicity Of D-agnps and D-aunps In Lung Cancer mentioning

confidence: 99%

“…In previous studies, the cytotoxic effects of AgNPs on cancer cells, along with the noncytotoxic effects of AuNPs, were similar to our findings. 26,27,[29][30][31] Suliman et al reported 32 AgNPs show less cytotoxicity on A549 cell compared with D-AgNPs at same concentration. Next, the synergistic effect between Dendropanax nanoparticles (silver and gold) and the ginsenoside CK was determined.…”

Section: In Vitro Cytotoxicity Of D-agnps and D-aunps In Lung Cancer mentioning

confidence: 99%

“…Previous studies have reported the ability of AgNPs and AuNPs to induce apoptosis. 26,36 We evaluated the ability of D-AgNPs alone or in combination with CK to induce cellular apoptosis based on Hoechst 33258 staining. We found that D-AgNPs alone induced changes in the nuclear morphology of many cells at 50 µg/mL, but combination treatment with 50 µg/mL of D-AgNPs with 25 µM of CK exhibited even more apoptotic bodies.…”

Section: D-agnps and D-aunps Induce Apoptosis In A549 Cellsmentioning

confidence: 99%

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Rapid green synthesis of silver and gold nanoparticles using Dendropanax morbifera leaf extract and their anticancer activities

Kim¹,

Wang²,

Mathiyalagan³

et al. 2016

IJN

110

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Dendropanax morbifera Léveille is an oriental medicinal plant that is traditionally used in folk medicine and grows in a specific region of South Korea. We aimed to enhance the utilization of D. morbifera medicinal plants for synthesis of silver nanoparticles (AgNPs) and gold nanoparticles (AuNPs). D. morbifera leaf extract acted as both a reducing and a stabilizing agent that rapidly synthesized Dendropanax AgNPs (D-AgNPs) and Dendropanax AuNPs (D-AuNPs). The D-AgNPs and D-AuNPs were characterized by ultraviolet-visible spectroscopy, energy dispersive X-ray analysis, elemental mapping, field emission transmission electron microscopy, X-ray diffraction, and dynamic light scattering. The characterizations revealed that the D-AgNPs and D-AuNPs were in polygon and hexagon shapes with average sizes of 100–150 nm and 10–20 nm, respectively. The important outcomes were the synthesis of AgNPs and AuNPs within 1 hour and 3 minutes, respectively, avoiding the subsequent processing for removal of any toxic components or for stabilizing the nanoparticles. Additionally, D-AgNPs and D-AuNPs were examined for cytotoxicity in a human keratinocyte cell line and in A549 human lung cancer cell line. The results indicated that D-AgNPs exhibited less cytotoxicity in the human keratinocyte cell line at 100 µg/mL after 48 hours. On the other hand, D-AgNPs showed potent cytotoxicity in the lung cancer cells at the same concentration after 48 hours, whereas D-AuNPs did not exhibit cytotoxicity in both cell lines at the same concentration. However, both D-AgNPs and D-AuNPs at 50 µg/mL enhanced the cytotoxicity of ginsenoside compound K at 25 µM after 48 hours of treatment compared with CK alone. We believe that this rapid green synthesis of D-AgNPs and D-AuNPs is a valuable addition to the applications of D. morbifera medicinal plant. D-AuNPs can be used as carriers for drug delivery and in cancer therapy due to their lack of normal cell cytotoxicity.

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Section: In Vitro Cytotoxicity Of D-agnps and D-aunps In Lung Cancer mentioning

confidence: 99%

Section: In Vitro Cytotoxicity Of D-agnps and D-aunps In Lung Cancer mentioning

confidence: 99%

Section: D-agnps and D-aunps Induce Apoptosis In A549 Cellsmentioning

confidence: 99%

See 1 more Smart Citation

Rapid green synthesis of silver and gold nanoparticles using Dendropanax morbifera leaf extract and their anticancer activities

Kim¹,

Wang²,

Mathiyalagan³

et al. 2016

IJN

110

View full text Add to dashboard Cite

show abstract

“…In its nanoscale form, silver exhibits unique physicochemical and biological activities. This has made them useful as sensor, vector control, antimicrobial, anticancer, and antiplasmodial agents, catalysts, among others (Elemike et al 2014;Ashokkumar et al 2013;Vinod et al 2014;Ravi et al 2013;Kathiravan et al 2014;Raju et al 2012;Saraschandra and Sivakumar 2014;Rajakumar and Abdul Rahuman 2011;Namita and Soam 2014). Biological/green method of synthesizing silver nanoparticles uses various plants, plant parts or microorganisms to reduce silver ion to silver nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis of silver nanoparticles using aqueous leaf extract of Thevetia peruviana Juss and its antimicrobial activities

et al. 2015

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Biosynthesizing of silver nanoparticles using microorganisms or various plant parts have proven more environmental friendly, cost-effective, energy saving and reproducible when compared to chemical and physical methods. This investigation demonstrated the plant-mediated synthesis of silver nanoparticles using the aqueous leaf extract of Thevetia peruviana. UV-Visible spectrophotometer was used to measure the surface plasmon resonance of the nanoparticles at 460 nm. Fourier Transform Infrared showed that the glycosidic -OH and carbonyl functional group present in extract were responsible for the reduction and stabilization of the silver nanoparticles. X ray diffraction, Scanning Electron Microscopy, Transmission Electron Microscopy and Selected Area Electron Diffraction analyses were used to confirm the nature, morphology and shape of the nanoparticles. The silver nanoparticles are spherical in shape with average size of 18.1 nm. The synthesized silver nanoparticles showed activity against fungal pathogens and bacteria. The zone of inhibition observed in the antimicrobial study ranged between 10 and 20 mm.

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“…Among them, plant materials have been of special interest to scientific community due to their eco-friendliness and are advantageous over other biological processes because they eliminate the elaborate process of maintaining cell structures and can also be suitably scaled up for large scale synthesis of nanoparticles. AgNPs synthesis using leaf extract has already been reported with various plants [10][11][12][13][14]. Reported that the banana peel extract mediated AgNPs haves hown efficient antimicrobial activity towards most of the tested fungal and bacterial cultures (Ramamurthy et al).…”

Section: Introductionmentioning

confidence: 99%

Bio Synthesis and Characterization of Silver Nanoparticles Using Lagenaria siceraria Leaf Extract and their Antibacterial Activity

Anandh¹,

Muthuvel²,

Emayavaramban³

2014

ILCPA

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The present investigation demonstrates the formation of silver nanoparticles by the reduction of the aqueous silver metal ions during exposure to the Lagenaria siceraria leaf extract. The synthesized AgNPs have characterized by UV-visible spectroscopy, X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FT-IR) techniques. AgNPs formation has screened by UV-visible spectroscopy through colour conversion due to surface plasma resonance band at 427 nm. X-ray diffraction (XRD) confirmed that the resulting AgNPs are highly crystalline and the structure is face centered cubic (fcc). FT-IR spectrum indicates the presence of different functional groups present in the biomolecules capping the nanoparticles. Further, inhibitory activity of AgNPs and leaf extract were tested against human pathogens like gram-pastive (Staphylococcus aureus, Bacillus subtilis), gram-negative (Escherichia coli and Pseudomonas aeruginosa). The results indicated that the AgNPs showed moderate inhibitory actions against human pathogens than Lagenaria siceraria leaf extract, demonstrating its antimicrobial value against pathogenic diseases.

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Synthesis of silver nanoparticles from Melia dubia leaf extract and their in vitro anticancer activity

Cited by 210 publications

References 36 publications

Rapid green synthesis of silver and gold nanoparticles using<em> Dendropanax morbifera</em> leaf extract and their anticancer activities

Rapid green synthesis of silver and gold nanoparticles using<em> Dendropanax morbifera</em> leaf extract and their anticancer activities

Biosynthesis of silver nanoparticles using aqueous leaf extract of Thevetia peruviana Juss and its antimicrobial activities

Bio Synthesis and Characterization of Silver Nanoparticles Using <i>Lagenaria siceraria</i> Leaf Extract and their Antibacterial Activity

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