Synthesis of Schiff Bases Compounds from Oxamic Hydrazide: Spectroscopic Characterization, X–ray Diffraction Structure and Antioxidant Activity Study

Abstract

The compounds (E)-2-amino-N'-(1-(2-hydroxyphenyl)ethylidene)-2-oxoacetohydrazide (I) and (E)-N'-(2hydroxy-3-methoxybenzylidene)-2-amino-2-oxoacetohydrazide (II) were synthetized by the 1:1 ratio condensation reaction of oxamic hydrazide and 2-hydroxyacetophenone or o-vanillin respectively. The two compounds were characterized by physico-chemical analyses, elemental analysis, FTIR, 1 H and 13 C NMR spectroscopies techniques. The structure of the compound (I) was determined by single-crystal X-ray diffraction study. The compound (I) (C 10 H 11 N 3 O 3 ) crystallises in the triclinic space group P-1 with the following unit cell parameters: