A Systematic Review on Synthetic and Antimicrobial Bioactivity of the Multifaceted Hydrazide Derivatives

Abstract

: To overcome the upsurge of antimicrobial resistance that has emerged in recent years, there is a need for the development of newer hits having gratifying anti-infective activity. Hydrazides incorporated with an azomethine hydrogen account for a cardinal class of molecules for the development of newer derivatives. Hydrazide derivatives have gainedconsiderable interest of medicinal chemists owing to their diverse bioactivity. In the present review, we have attempted to compile the recent trends in the synthesis of hydrazides and their substituted derivatives. The structural features that lead to the desired antimicrobial activity are highlighted, which will lead the way for synthetic and medicinal chemists to focus on newer designs in this arena.