Synthesis of platinum nanoparticles using seaweed Padina gymnospora and their catalytic activity as PVP/PtNPs nanocomposite towards biological applications

Ramkumar, Vijayan Sri; Pugazhendhi, Arivalagan; Prakash, S.; Ahila, Natarajan Kumari; Gopalakrishnan, Vinoj; Selvam, S.; Kumar, Govindarajan Venkat; Ethiraj, Kannapiran; Rajendran, Rahini

doi:10.1016/j.biopha.2017.05.076

Cited by 121 publications

(46 citation statements)

References 58 publications

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“…4 Nanomaterials have been found to possess efficient activities to catalyze a lot of chemical reactions. [5][6][7][8][9] Metal nanoparticles are particularly good catalysts due to the high concentration of surface electrons. Platinum nanoparticles (PtNPs) can act as strong and stable mimetics of superoxide dismutase and catalase, [10][11][12] and have been demonstrated to effectively attenuate oxidative stress-induced pulmonary inflammation and neurological impairment in mice.…”

Section: Introductionmentioning

confidence: 99%

<p>Platinum Nanoparticles As A Therapeutic Agent Against Dextran Sodium Sulfate-Induced Colitis In Mice</p>

Zhu

Zeng²,

Feng³

et al. 2019

IJN

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Purpose: This study aimed to evaluate the anti-colitis potential of platinum nanoparticles (PtNPs). Materials and methods: 5-, 30-and 70-nm PtNPs were administered to C57BL/6 mice once daily by intragastric gavage for 8 d during and after 5-d dextran sodium sulfate treatment. Results: According to body weight change, stool blood and consistency, and colon length and histopathology, PtNPs size-dependently alleviated DSS-induced murine colitis. PtNPs enhanced gut-barrier function by upregulating the colonic expressions of heat-shock protein 25 and tight junction proteins. Based on colonic myeloperoxidase activity, colonic and peripheral levels of interleukin-6 and tumor necrosis factor-α, and peripheral counts of white blood cells, PtNPs attenuated colonic and systemic inflammation. By suppressing lipopolysaccharide-triggered production of proinflammatory mediators, including nitric oxide, tumor necrosis factor-α and interleukin-6, PtNPs exerted direct anti-inflammatory activities in RAW264.7 macrophages through a mechanism involving intracellular reactive oxygen species scavenging and Toll-like receptor 4/NF-κB signaling suppression. High-throughput 16S rRNA sequencing of fecal samples unveiled that PtNPs induced gut dysbiosis by unfavorably altering α-diversity, Firmicutes/Bacteroidetes ratio, and richness of certain specific bacteria. Conclusion: PtNPs are a promising anti-colitis agent, but may negatively impact gut-microbiota.

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Section: Introductionmentioning

confidence: 99%

<p>Platinum Nanoparticles As A Therapeutic Agent Against Dextran Sodium Sulfate-Induced Colitis In Mice</p>

Zhu

Zeng²,

Feng³

et al. 2019

IJN

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“…The seaweed extracts possesses bioactive metabolites like flavonoids, phenols, citric acid, ascorbic acid, polyphenolic, terpenes, alkaloids and reductase could act as reducing agents [14]. The earlier research suggest that there are some marine algae which are very good biological material for the synthesis of nanoparticles [15][16][17]. Interestingly we had done our study previously in Gelidiella acerosa for the first time, it has been reported that the synthesis of highly stable Ag-NPs, characterization and its antimicrobial activity [18].…”

Section: Introductionmentioning

confidence: 99%

Facile green synthesis of gold nanoparticles from marine algae Gelidiella acerosa and evaluation of its biological Potential

Senthilkumar¹,

Surendran²,

Sudhagar³

et al. 2019

SN Appl. Sci.

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In this present research, the Gold nanoparticles (GA-AuNPs) produced from Gelidiella acerosa, marine algae using green synthesis method was evaluated for its antidiabetic, antibacterial and antioxidant activity. Well-developed GA-AuNPs were effectively characterized using advanced analytical instruments like HRTEM, UV-visible, SEM and XRD. This analysis exposed GA-AuNPs to be present with spherical, hexagonal structure and crystalline nature. The average size of GA-AuNPs particles was estimated to lie between 5.81 nm to 117.59 nm by using Debye-Scherer equation. The enzyme inhibitory property of (IC 50 ) of G. acerosa aqueous extract and synthesized gold nanoparticles from G. acerosa against α amylase and α-glucosidase enzyme was found to be 2.1 ± 0.01, 3.7 ± 0.01 µg/mL and 2.8 ± 0.02, 4.1 ± 0.01, respectively. Further antioxidant assessment of GA-AuNPs were examined using DPPH and FRAP assays, the results exhibited that the strong antioxidant activity were observed in all the concentrations when compared with standard. Finally antibacterial activity was evaluated the GA-AuNPs against gram positive and gram negative bacteria, the strong antibacterial activity was observed in both the bacterial strains when compared with standard antibiotic. The GA-AuNPs from marine algae was exhibited to be strong inhibitory activity against alpha amylase and alpha glucosidase enzyme, antioxidant activity and antibacterial activity, these GA-AuNPs are projected to have potential biological applications.

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“…The measurement of zeta potential (ZP) is hinged on the surface charge of the nanoparticles, which is an obligatory measurement for the description of the stability of the nanoparticles in the solution. If nanoparticles are greater than +30 mV or less than −30 mV of ZPs, nanoparticles show strong stability . In this study, ZPs of AgNPs, PVP and AgNPs/PVP were evaluated (Figure ).…”

Section: Resultsmentioning

confidence: 99%

Electrochemical Determination of Ascorbic Acid Based on AgNPs/PVP‐Modified Glassy Carbon Electrode

Karaboduk

2019

ChemistrySelect

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The electrochemical determination of ascorbic acid was carried out at the surface of glassy carbon electrode (GCE) modified by silver nanoparticles (AgNPs):Polyvinylpyrrolidone (PVP). Nanocomposite was evaluated by fourier transform infrared spectroscopy, zeta potential, and X‐ray diffraction. Also, the surface morphologies of the developed electrode were investigated by scanning electron microscopy, and profilometer. The electrochemical performance of AgNPs/PVP/GCE was studied with cyclic voltammetry and electrochemical impedance spectroscopy measurements. The electrochemical studies demonstrated that the electrode had a large surface. Compared with the bare GCE, PVP/GCE, and AgNPs/GCE, the AgNPs/PVP‐modified GCE showed excellent performance for the electrochemical determination of ascorbic acid. At the optimized conditions of differential pulse voltammetry in pH 6.0 of phosphate buffer solution, the modified electrode allowed the determination of ascorbic acid on a potential of 0.54 V vs. Ag/AgCl. Under optimized conditions, the low detection limit of 0.047 μM and working range of 0.2‐1200 μM were obtained at the AgNPs/PVP/GCE. The AgNPs/PVP/GCE allowed to obtain highest peak current values at low concentrations. Moreover, the fabricated electrode also exhibited good repeatability, reproducibility, and stability. The developed electrode was successfully enforced for the analysis of ascorbic acid in banana, kiwi fruit, mango, and pineapple.

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Synthesis of platinum nanoparticles using seaweed Padina gymnospora and their catalytic activity as PVP/PtNPs nanocomposite towards biological applications

Cited by 121 publications

References 58 publications

<p>Platinum Nanoparticles As A Therapeutic Agent Against Dextran Sodium Sulfate-Induced Colitis In Mice</p>

<p>Platinum Nanoparticles As A Therapeutic Agent Against Dextran Sodium Sulfate-Induced Colitis In Mice</p>

Facile green synthesis of gold nanoparticles from marine algae Gelidiella acerosa and evaluation of its biological Potential

Electrochemical Determination of Ascorbic Acid Based on AgNPs/PVP‐Modified Glassy Carbon Electrode

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