Synthesis of novel steroidal curcumin derivatives as anti-Alzheimer’s disease candidates: Evidences-based on in vivo study

Elmegeed, Gamal A.; Ahmed, Hanaa H.; Hashash, Maher A.; Abdelhalim, Mervat M.; El-kady, Dina S.

doi:10.1016/j.steroids.2015.06.003

Cited by 42 publications

(23 citation statements)

References 57 publications

(56 reference statements)

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“…Elmegeed and colleagues (2015) [90] studied the effects of curcumin in the regression of AD induced in adult female albino rats. The results revealed that treatment of AD groups with compounds 3, 5, 8c or rivastigmin experienced significant increase in brain Ach, GSH, paraoxenase and BCL2 levels with respect to untreated group associated with significant decrease in brain AchE activity, urinary 8-OHG level, serum Caspase-3 level and brain P53 level relative to the untreated group.…”

Section: Research On Curcumin In Mouse Models Of Alzheimer’s Diseasementioning

confidence: 99%

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Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease

Reddy

Mańczak

Yin

et al. 2018

JAD

277

138

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The purpose of our article is to assess the current understanding of Indian spice ‘Curcumin’ against amyloid-β (Aβ)-induced toxicity in Alzheimer’s disease (AD) pathogenesis. Natural products, such as ginger, curcumin and gingko biloba have been used as diets and dietary supplements to treat human diseases, including cancer, cardiovascular, respiratory, infectious, diabetes, obesity, metabolic syndromes and neurological disorders. Products derived from plants are known to have protective effects, including anti-inflammatory, anti-oxidant, anti-arthritis, pro-healing and boosting memory cognitive functions. In the last decade, several groups have designed and synthesized curcumin and its derivatives and extensively tested using cell and mouse models of AD. Recent research on amyloid-β and curcumin has revealed that curcumin prevents amyloid-β aggregation and crosses the blood brain barrier (BBB), reach brain cells and protect neurons from various toxic insults of aging and amyloid-β in humans. Recent research has also reported that curcumin ameliorates cognitive decline and improves synaptic functions in mouse models of AD. Further, recent groups have initiated studies on elderly individuals and patients with AD and the outcome of these studies is currently being assessed. This article highlights the beneficial effects of curcumin on AD. This article also critically assesses the current limitations of curcumin’s bioavailability and urgent need for new formulation to increase its brain levels to treat patients with AD.

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Section: Research On Curcumin In Mouse Models Of Alzheimer’s Diseasementioning

confidence: 99%

“…The activity of tested compounds showed gradual increase from compound b followed by compound 8c then compound 5. The anti-cholinesterase potential, anti-oxidant properties and anti-apoptotic activity are responsible for the anti-AD potential of these compounds [90]. …”

Section: Research On Curcumin In Mouse Models Of Alzheimer’s Diseasementioning

confidence: 99%

Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease

Reddy

Mańczak

Yin

et al. 2018

JAD

277

138

View full text Add to dashboard Cite

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“…Oxidative stress has been reported as one of the main pathognomonic features of AD. Numerous studies have demonstrated the presence of lipid, protein, and nucleic acid oxidation products in the harvested brains of those afflicted with AD . Therefore, a therapeutic strategy that aimed at either removal of free radicals or prevention of their formation might be an alternative approach for slowing the progression of AD.…”

Section: Alzheimer's Diseasementioning

confidence: 99%

Biological properties of metal complexes of curcumin

et al. 2019

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Curcumin, a naturally occurring phenolic compound isolated from Curcuma longa, has different pharmacological effects, including antiinflammatory, antimicrobial, antioxidant, and anticancer properties. However, curcumin has been found to have a limited bioavailability because of its hydrophobic nature, low-intestinal absorption, and rapid metabolism. Therefore, there is a need for enhancing the bioavailability and its solubility in water in order to increase the pharmacological effects of this bioactive compound. One strategy is curcumin complexation with transition metals to circumvent the abovementioned problems. Curcumin can undergo chelation with various metal ions to form metallo-complexes of curcumin, which may show greater effects as compared with curcumin alone. Promising results with metal curcumin complexes have been observed with regard to antioxidant, anticancer, and antimicrobial activity, as well as in treatment of Alzheimer's disease. The present review provides a concise summary of the characterization and biological properties of curcumin-metal complexes. © 2019 BioFactors, 45(3):304-317, 2019

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“…In addition, phenylpropanoids from cinnamon [640] and coffee [641] have β-secretase regulating and anti-aggregation functions. Curcumin derivatives are widely explored as drugs [570,642,643] against AD and work as anti-oxidant metal chelators and 57 interact with Aβ [491,570]. The natural role of such compounds in modulating Aβ-metal relationships is…”

Section: Multifunctional Natural Compounds Against Admentioning

confidence: 99%

Alzheimer’s disease: How metal ions define β-amyloid function

Kepp

2017

Coordination Chemistry Reviews

133

139

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Synthesis of novel steroidal curcumin derivatives as anti-Alzheimer’s disease candidates: Evidences-based on in vivo study

Cited by 42 publications

References 57 publications

Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease

Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease

Biological properties of metal complexes of curcumin

Alzheimer’s disease: How metal ions define β-amyloid function

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