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Screening for antidepressant, sedative and analgesic activities of novel fused thiophene derivativesThis study was aimed at the synthesis of fused benzothiophene derivatives containing heterocyclic moiety. The reaction of the tetrahydrobenzo[b]thiophene derivatives1a,bwith ethoxycarbonylisothiocyanate afforded the thiourea derivatives2a,b.Cyclization of the latter products gave the annulated benzo[b]thienopyrimidine derivatives3a,b.Compounds2a,band3aunderwent a series of heterocyclization reactions through the reaction with some chemical reagents to give the new benzo[b]thienopyrimidine derivatives5a,bto8a-c.Also, this work was extended to study the potential role of the novel synthesized thiourea derivative2aand benzo[b]thienopyrimidine derivatives3a, 5b, 6aand8bas antidepressant, sedative or analgesic agents at two doses (15 or 30 mg kg-1body mass). Some compounds (2a, 3aand5b) showed mild antidepressant activity in the forced-swimming test. No compound showed sedative effect. Visceral pain evoked byi.p.injection of acetic acid in mice was significantly inhibited by all compounds at a high doses.

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