Synthesis of novel furobenzopyrone derivatives and evaluation of their antimicrobial and antiinflammatory activity

Recent progress on coumarinscaffold‐basedanti‐microbial agents (PartIII)

“…Pechmann reaction of resorcinol and ethylacetoacetate in the presence concentrated sulfuric acid gave 7‐hydroxy‐4‐methylcoumarin, [ 102 ] which fused with aromatic aldehydes namely benzaldehyde, anisaldehyde and nicotinaldehyde at 120°C to 130°C to get coumarin derivatives 164a‐c . Compound 164a underwent Mannich reaction with glycine and formalin 38‐40% in ethanol/water giving the compound 165 .…”