Recent progress on coumarin<scp>scaffold‐based</scp>anti‐microbial agents (Part<scp>III</scp>)

Gouda, Moustafa A.; Abu‐Hashem, Ameen A.; Salem, Mohamed Salem Ould Ahmedou; Helal, Mohamed H.; Al‐Ghorbani, Mohammed; Hamama, Wafaa S.

doi:10.1002/jhet.4100

Cited by 12 publications

(3 citation statements)

References 83 publications

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“…Another important derivative is theobromine, which is a weak central stimulant and low adenosine antagonist [41] . Our research group published numerous articles on the synthesis of purine derivatives and other biologically active heterocyclic compounds [42–69] …”

Section: Introductionmentioning

confidence: 99%

Caffeine and Purine Derivatives: A Comprehensive Review on the Chemistry, Biosynthetic Pathways, Synthesis‐Related Reactions, Biomedical Prospectives and Clinical Applications

Abu‐Hashem,

Hakami,

El‐Shazly

et al. 2024

Chemistry & Biodiversity

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Caffeine and purine derivatives represent interesting chemical moieties, which show various biological activities. Caffeine is an alkaloid that belongs to the family of methylxanthine alkaloids and it is present in food, beverages, and drugs. Coffee, tea, and some other beverages are a major source of caffeine in the human diet. Caffeine can be extracted from tea or coffee using hot water with dichloromethane or chloroform and the leftover is known as decaffeinated coffee or tea. Caffeine and its derivatives were synthesized via different procedures on small and large scales. It competitively antagonizes the adenosine receptors (ARs), which are G protein‐coupled receptors largely distributed in the human body, including the heart, vessels, brain, and kidneys. Recently, many reports showed the effect of caffeine derivatives in the treatment of many diseases such as Alzheimer's, asthma, parkinsonism, and cancer. Also, it is used as an antioxidant, anti‐inflammatory, analgesic, and hypocholesterolemic agent. The present review article discusses the synthesis, reactivity, and biological and pharmacological properties of caffeine and its derivatives. The biosynthesis and biotransformation of caffeine in coffee and tea leaves and the human body were summarized in the review.

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Section: Introductionmentioning

confidence: 99%

Caffeine and Purine Derivatives: A Comprehensive Review on the Chemistry, Biosynthetic Pathways, Synthesis‐Related Reactions, Biomedical Prospectives and Clinical Applications

Abu‐Hashem,

Hakami,

El‐Shazly

et al. 2024

Chemistry & Biodiversity

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“…Recently various antibacterial agents integrated with heterocyclic frameworks such as quinazoline [12, 13], coumarin [14, 15], pyrazole [16, 17], imidazole [18, 19], flavones [20, 21], benzimidine [22, 23] etc. were identified as effective antibacterial drugs.…”

Section: Introductionmentioning

confidence: 99%

Imidazo[1,2‐a]pyridine as a promising scaffold for the development of antibacterial agents

Mishra

Mohapatra

Das

et al. 2022

Journal of Heterocyclic Chem

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The fascinating molecular structure and versatile bioactivity of imidazo[1,2‐a]pyridine scaffold attracts the scientific community to develop new imidazo[1,2‐a]pyridine based antibacterial agent in current situation. This systematic review provides a deep insight into the recent advances of imidazo[1,2‐a]pyridine derivatives and its antibacterial activities from 2010 to 2021. Moreover, the structure–activity relationship and synthetic approaches are also cautiously summarized throughout the review which affords a clear vision for the medicinal chemists to design new antibacterial agents.

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“…Coumarins, whether SCs or NOCs, have been the subject of extensive studies because of their useful and diverse biological activities, such as photochemotherapy, anti-coagulant, anti-cancer, anti-thrombotic, anti-inflammatory, anti-HIV, anti-bacterial, anti-coagulant. antimicrobial, anti-inflammatory, anti-influenza, anti-tuberculosis, anti-asthmatic, anti-hyperlipidemic, anti-platelet, anti-Alzheimer, anti-oxidant, anti-allergic and monoamine oxidase (MAO) inhibitory activities (1,(7)(8)(9)(10).…”

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confidence: 99%

7,8-Diacetoxy-3-(4-methylsulfonylphenyl)-4-phenylcoumarin Induces ROS-dependent Cell Death in the A549 Human Lung Cancer Cell Line

MUSA¹,

KOLAWOLE²

2023

Anticancer Res

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Background/Aim: Coumarins comprise of a very large class of naturally occurring compounds with growing interest in their synthesis and possible applications in the treatment of various diseases. We herein report the in-vitro cytotoxic activity of 3, in A549 (lung) and PC-3 (prostate) cancer cell lines. Materials and Methods: The cytotoxic activity was evaluated using crystal violet dyebinding. The most active compound effect on the cell-cycle phases, mitochondrial membrane potential (MMP), reactive oxygen species (ROS) production and apoptosis were also evaluated. Results: Among the synthesized compounds that were evaluated, 7,8-Diacetoxy-3-(4-(methylsulfonyl)phenyl)-4phenylcoumrin (4f) showed highest cytotoxicity (CC 50 =13.5%±0.15μM) in A549 cancer cell line . The mechanism of its cytotoxic action indicated significant cell arrest in G 1 /G 0 , S and G2 phases of the cell cycle, loss of mitochondrial membrane potential (MMP), increase in reactive oxygen species (ROS) production and induction of apoptotic cell death. The cell viability result of pretreated A549 cells with antioxidant N-acetylcysteine (NAC), followed by compound 4f treatment confirmed ROS-dependent cell death. Conclusion: The presence of 3-4-methylsulfonyl and 7,8-diacetoxy groups on 3,4-Diarylcoumarin is critical in modulating higher cytotoxic activity and could serve as a valuable template for the development of novel synthetic compounds as potential anticancer agents for lung cancer treatment.

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Recent progress on coumarinscaffold‐basedanti‐microbial agents (PartIII)

Cited by 12 publications

References 83 publications

Caffeine and Purine Derivatives: A Comprehensive Review on the Chemistry, Biosynthetic Pathways, Synthesis‐Related Reactions, Biomedical Prospectives and Clinical Applications

Caffeine and Purine Derivatives: A Comprehensive Review on the Chemistry, Biosynthetic Pathways, Synthesis‐Related Reactions, Biomedical Prospectives and Clinical Applications

Imidazo[1,2‐a]pyridine as a promising scaffold for the development of antibacterial agents

7,8-Diacetoxy-3-(4-methylsulfonylphenyl)-4-phenylcoumarin Induces ROS-dependent Cell Death in the A549 Human Lung Cancer Cell Line

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