Synthesis of novel fullerene α-amino acid conjugates

Zhang, Jing; Wang, Yan Xia; Kang, Feng; Shao, Ying; Li, Zong Jie; Yang, Xin

doi:10.1016/j.cclet.2008.06.035

Cited by 7 publications

(8 citation statements)

References 21 publications

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“…The fullero pyrrolidine and the fuller-serine were synthesized and the chemical structure of fullero pyrrolidine was confirmed by data of MALDI-TOF-MS and 1 H NMR, which matched very much those reported by Zhang et al [12,19]. In the UV-VIS, the character apex of C60 reaction is 430nm, which showed that C60 had reaction with pyrrolidine.…”

Section: A Preparation Of Nano Fuller-serinesupporting

confidence: 60%

“…First the fulleropyrrolidine was synthesized by literature procedures [12]. First, fulleropyrrolidine N-substituted with an ethyleneglycol chain was obtained by 1,3-Dipolar cycloaddition of the azomethine ylide generated by condensation of N-substituted glycine with formaldehyde to C 60 .…”

Section: B Synthesis Of Fuller-serinementioning

confidence: 99%

“…And their various functional groups and other solubilization procedures can change the ROSgenerating or quenching capacity. Fortunately, chemical functionalization of fullerenes can be achieved [10][11][12], and nano-fullerenes can be prepared, resulting in the preparation of water-soluble organ-fullerene compounds applicable to biological investigation [2,[13][14][15][16]. As nanomaterial production increases due to development and commercialization of new applications, there is a need to understand the effect of ROS generation by fullerene nanoparticles on human health and natural environmental systems.…”

Section: Introductionmentioning

confidence: 99%

“…The protective effect of a -alanine C 60 derivative [13] and a cystine C 60 derivative on hydrogen peroxide-induced oxidative stress and apoptotic death in cultured rat PC12 cells is apparent and without evident toxicity. The bio-molecules attached may also improve or product new biological effectives [12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

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Preparation and Radical Scavenging Activity of Nano-Fuller-Serine

Zhang

et al. 2012

2012 International Conference on Biomedical Engineering and Biotechnology

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The fuller-serine was synthesized and then dissolved in the organic solvent and then the nanoparticle aqueous suspension of fuller-serine was prepared. The nanoparticle sizes and Zeta-potentials were obtained by TEM and a Zeta-patential instrument, respectively. The results indicated that the aqueous nano-particle suspensions were rather considerably stable with homogeneous size. The free radicals scavenging of nano fuller-serine were determined by means of pyrogallol oxidation. The result indicated it was useful to scanvenge oxygen free radicals in a concentration dependent manner. Whether they are able to protect biological systems from oxidative damages or not needs to be further investigated.

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Section: A Preparation Of Nano Fuller-serinesupporting

confidence: 60%

Section: B Synthesis Of Fuller-serinementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preparation and Radical Scavenging Activity of Nano-Fuller-Serine

Zhang

et al. 2012

2012 International Conference on Biomedical Engineering and Biotechnology

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“…Solvents were dried according to previously described method before use [18]. Toluene (PhMe) was refluxed with calcium hydride at 120℃ for 1.5-2.5h under continuous flow of argon and then distilled.…”

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confidence: 99%

Solid Phase Synthesis of Novel Fullerene Nucleotides Conjugates

Zhang

2011

AMR

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N-substituted 3, 4-fullero pyrrolidine was synthesized according to 1, 3-dipolar cycloaddition of the azomethine ylide. Aspartic acid with protected α-amino and α-carboxyl groups was reacted with the activated hydroxyl group of N-substituted 3, 4-fullero pyrrolidine. The products were deprotected, affording the monofullerene aspartic acid (mFas). The conjugate FasT was synthesized by reaction of mFas containing protected amino group with the thymidylic acid derivatived controlled pore glass (CPG) using solid phase synthesis. All of the above fullerene derivatives were characterized by UV–vis, 1H NMR, IR and MS spectrometric analysis, giving the correct spectra with regard to their chemical structure. The chemical structures of fullerene nucleotides conjugate FasT is different from previous reports and may have novel biological properties. Moreover, they are more suitable for applications in biomedical research due to their solubilization in THF and DMSO. They have a potential to be used as monomer for the automatic synthesis. It allows further conjugation with specific biomolecules including amino acids, peptides, nucleotides and nucleic acids. A novel method has been developed to synthesize fullerene nucleotides conjugate. Their unique chemical structures make them very interesting for their potential use in medicine and biology.

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