N-substituted 3, 4-fullero pyrrolidine was synthesized according to 1, 3-dipolar cycloaddition of the azomethine ylide. Aspartic acid with protected α-amino and α-carboxyl groups was reacted with the activated hydroxyl group of N-substituted 3, 4-fullero pyrrolidine. The products were deprotected, affording the monofullerene aspartic acid (mFas). The conjugate FasT was synthesized by reaction of mFas containing protected amino group with the thymidylic acid derivatived controlled pore glass (CPG) using solid phase synthesis. All of the above fullerene derivatives were characterized by UV–vis, 1H NMR, IR and MS spectrometric analysis, giving the correct spectra with regard to their chemical structure. The chemical structures of fullerene nucleotides conjugate FasT is different from previous reports and may have novel biological properties. Moreover, they are more suitable for applications in biomedical research due to their solubilization in THF and DMSO. They have a potential to be used as monomer for the automatic synthesis. It allows further conjugation with specific biomolecules including amino acids, peptides, nucleotides and nucleic acids. A novel method has been developed to synthesize fullerene nucleotides conjugate. Their unique chemical structures make them very interesting for their potential use in medicine and biology.
N-substituted 3,4-fullero pyrrolidine was synthesized according to 1,3-Dipolar cycloaddition of the azomethine ylide. Aspartic acid and glutamic acid with protected α-amino and α-carboxyl groups were reacted with the activated hydroxyl group of N-substituted 3,4-fullero pyrrolidine, respectively. The products were deprotected, affording two novel fullerene α-amino acids, fullerene aspartic acid and fullerene glutamic acid. Their chemical structures were characterized by MALAI-TOF-MS, UV-Vis, FT-IR and 1HNMR. Both fullerene amino acids with a free amino group and a free carboxyl group would have unique property and potential use in medicine and biology. A novel method has been developed to synthesize fullerene conjugate. Their unique chemical structures make them very interesting for their potential use in medicine and biology.
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