Eur. J. Chem. volume 6, issue 2, P163-168 2015 DOI: 10.5155/eurjchem.6.2.163-168.1224
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Abdul Rauf, Khalil Ahmed Nazish, Faiz-ul Hassan Nasim, Asma Yaqoob, Ashfaq Mahmood Qureshi
Abstract:

The present study reports a convenient approach for the synthesis of cyanoacetamide based derivatives (7-27) via two-step process involving Knoevenagel reaction, followed by three component reaction to avail desired compounds. All the synthesized compounds were obtained in good to excellent yield and extensively characterized employing 1 H NMR, 13 C NMR, mass spectrometry and physical parameters. Further, these compounds were screened for urease inhibition. All of the synthesized compounds exhibited good …

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