Synthesis of novel 4,6-disubstituted quinazoline derivatives, their anti-inflammatory and anti-cancer activity (cytotoxic) against U937 leukemia cell lines☆

Regioselective Suzuki-Miyaura Reaction: Application to the Microwave-promoted Synthesis of 4,7-Diarylquinazolines

“…Especially, their importance as selective anticancer chemotherapy agents appears unparalleled and attracts the attention of many pharmaceutical research teams worldwide [10][11][12][13]. Focusing on quinazoline substrates, our group also quite recently described the preparation of new 2-substituted-quinazoline derivatives which exhibit original antiplasmodial properties [14][15][16].…”

Quinazoline pharmacophore in therapeutic medicine

“…For the past few decades now, a probable conjunction between the application of non-steroidal antiinflammatory agents (NSAIDs) and modified cases of cancer has continued to exist as special topic that needs intense evaluation and research (Chandrika et al, 2008). Using NOS-II as biomarker indicator, generally, quinazoline motifs are well-known to exhibit significant anti-inflammatory properties as inhibitors of NOS-II (Farag et al, 2013;Tinker et al, 2003), NFKB, TNF- (Serya et al, 2015), IMPDH-II (Rajput and Mishra, 2012), MAPK, IL-6, PDE-3 and PDE-4 (Serya et al, 2015).…”

Nucleophilic Aroylation on Fluoroquinazolines Catalyzed by N-Heterocyclic Carbenes

“…Quinazoline derivatives have been attracting increased attention due to their well-pronounced biological (e.g., anti-malaria, 1 antitumor, 2 anti-inflammatory, 3,4 and anti-hypertensive) 5 activity, as exemplified by Afatinib and Elotinib, both of which are tyrosine kinase inhibitors used for cancer treatment. 6 Further examples include Prazosin (anti-hypertensive), reactivity of NHCs allows aldehyde carbonyls to react with electrophiles, with this type of reaction being mediated exclusively by NHCs and the cyanide ion.…”