Nucleophilic Aroylation on Fluoroquinazolines Catalyzed by N-Heterocyclic Carbenes

Abstract

-We report on the synthesis of 7-benzoyl-and 7-heteroaroylquinazolines from 7-fluoroquinazolines and aromatic aldehydes by N-heterocyclic carbene (NHC)-catalyzed nucleophilic aromatic substitution, showing that the NHC derived from 1,3-dimethylimidazolium iodide outperformed those originating from other azolium (e.g., thiazolium and triazolium) salts. Additionally, the developed methodology allowed the preparation of 5-and 8-aroylquinazolines from the corresponding fluoroquinazolines.

Is ΛCDM an effective CCDM cosmology?

“…In Figure 1, we display the likelihood for the net parameter, α i , based on a flat matter creation Universe driven by N non-relativistic components. The analysis performed with the SNe Ia data (Union2.1 sample [26]) provided the constraint α i = 0.722 ± 0.021 (1σ). The horizontal lines correspond to cuts in the regions of 68.3% and 95.4% probability.…”