Synthesis of new thermo/pH sensitive drug delivery systems based on tragacanth gum polysaccharide

Hemmati, Khadijeh; Ghaemy, Mousa

doi:10.1016/j.ijbiomac.2016.03.005

Cited by 82 publications

(26 citation statements)

References 49 publications

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“…(A) could not be observed, suggesting that all the hydroxyl groups of HO‐PBS‐OH had reacted. Meanwhile, a new single resonance peak was observed at δ 1.95 ppm, which was assigned to the methyl protons (signal e) of 2‐bromoisobutyryl groups . Finally, the copolymer of PMPC‐ b ‐PBS‐ b ‐PMPC was synthesized by ATRP using Br‐PBS‐Br as a macro‐initiator.…”

Section: Resultsmentioning

confidence: 99%

Fabrication of micelles from poly(butylene succinate) and poly(2‐methacryloyloxyethyl phosphorylcholine) copolymers as a potential drug carrier

Zhang

Bao

et al. 2017

Polymer International

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A series of copolymers of poly(2‐methacryloyloxyethyl phosphorylcholine)‐b‐poly(butylene succinate)‐b‐poly(2‐methacryloyloxyethyl phosphorylcholine) (PMPC‐b‐PBS‐b‐PMPC) were synthesized by atom transfer radical polymerization. The structure of the polymers was characterized by 1H NMR and infrared spectroscopy, and their thermal properties were described using TGA and DSC. In aqueous solutions, the PMPC‐b‐PBS‐b‐PMPC could form micelles with sizes ranging from 108 to 170 nm. In vitro release studies showed that acidic media and a longer PMPC chain benefited doxorubicin (DOX) release. 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assays indicated that the micelles had low cytotoxicity to HeLa and L929 cells. DOX‐loaded micelles exhibited high cytotoxicity to HeLa cells. Flow cytometry results demonstrated that DOX‐loaded micelles could be internalized by HeLa cells. The in vitro phagocytosis results showed 3.9‐fold and 5.5‐fold reductions compared with poly(lactic acid) (PLA) nanoparticles and PDS55 micelles. These results demonstrate that PMPC‐b‐PBS‐b‐PMPC block copolymer micelles have great promise for cancer therapy. © 2017 Society of Chemical Industry

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Section: Resultsmentioning

confidence: 99%

Fabrication of micelles from poly(butylene succinate) and poly(2‐methacryloyloxyethyl phosphorylcholine) copolymers as a potential drug carrier

Zhang

Bao

et al. 2017

Polymer International

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“…In further advancement, dual responsive graft copolymer of TG and synthetic amphiphilic copolymer was synthesized by combining ring opening polymerization, atomic transfer radical polymerization, and click reaction. [ 38 ] The pH‐dependent in vitro release of QC from the graft copolymer was observed with a two‐phase‐release profile. A rapid release was observed during initial 5 h of release time and followed by sustained and slow release, with the cumulative release reaching ≈90% at pH 2.2 after 30 h. Another study involved the graft functionalization of TG with PAA using ascorbic acid‐potassium persulfate as initiator and glutaraldehyde as crosslinker.…”

Section: Applications Of Functional Tragacanth Gummentioning

confidence: 99%

Smart Designing of Tragacanth Gum by Graft Functionalization for Advanced Materials

Verma¹,

Pathania

Anjum³

et al. 2020

Macro Materials & Eng

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Tragacanth gum is a novel polysaccharide which offers interesting features in terms of high hydrophilicity, good biocompatibility, and biodegradability. The engineering of hydrogels requires careful designing of their macromolecular structures so that desirable features may be incorporated into the material. Graft polymerization has come up as an interesting approach to develop molecules for drug delivery, wound care systems, and infection‐resistant materials. The most important aspect of graft functionalization is the proper control over physico‐chemical properties of the grafted matrix. The extent of functionalization may be governed by the grafting parameters and may lead to the chemical designing of the molecule in a controlled manner. This opens up enormous possibilities of developing materials for a wide range of applications as advanced materials.

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“…The carboxyl groups undergo dehydration leading to the formation of an anhydride structure. The degradation beyond 300 °C (step III) may be assigned to main‐chain degradation where carboxyl and hydroxyl groups may undergo decomposition leading to char formation in the range 20–30% for all samples …”

Section: Resultsmentioning

confidence: 99%

Preparation of pH‐sensitive hydrogels by graft polymerization of itaconic acid on tragacanth gum

Verma

Negi

Pathania

et al. 2018

Polymer International

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Graft polymerization of itaconic acid on tragacanth gum (TG) was carried out using potassium persulfate as initiator to develop smart hydrogels for drug delivery systems. The effect of the grafting parameters on the degree of grafting was investigated. The grafting was significantly influenced by the reaction medium, the reaction temperature and the monomer concentration. The monomer dependency of the system was found to be 1.52. The hydrogels were characterized using Fourier transform infrared spectroscopy, thermogravimetric analysis, differential scanning calorimetry and X‐ray diffraction. The grafted TG had an amorphous nature and exhibited excellent swelling in water and strong dependence on the pH of the medium. The grafted TG showed pH‐dependent release of ciprofloxacin which offers the possibility of using these materials in colon‐specific drug targeting for human healthcare systems. © 2018 Society of Chemical Industry

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Synthesis of new thermo/pH sensitive drug delivery systems based on tragacanth gum polysaccharide

Cited by 82 publications

References 49 publications

Fabrication of micelles from poly(butylene succinate) and poly(2‐methacryloyloxyethyl phosphorylcholine) copolymers as a potential drug carrier

Fabrication of micelles from poly(butylene succinate) and poly(2‐methacryloyloxyethyl phosphorylcholine) copolymers as a potential drug carrier

Smart Designing of Tragacanth Gum by Graft Functionalization for Advanced Materials

Preparation of pH‐sensitive hydrogels by graft polymerization of itaconic acid on tragacanth gum

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