Synthesis of New Sulphanilamide Based Schiff Base Nickel Complexes With Study of Its Antibacterial Activity and Nanoparticle Synthesis

Abstract

Schiff base contains the Azomethine group prepared by reaction of the carbonyl group and amine group. In this project, Schiff bases of sulphanilamide on the treatment of imidazole-2-carboxaldehyde and Dehydroacetic acid have been synthesized. Further, their Nickel complexes have been synthesized. They were characterized by IR, Mass, NMR, UV-Vis spectra and found to have square planar geometry. They were screened with few bacteria and found to have good antibacterial activity against gram-negative bacteria. Further, NiO nanoparticles were synthesized by thermal decomposition of the above synthesized Nickel Schiff base complexes and found to have 93-98 nm particle size.

Synthesis, spectroscopic characterization, and thermal studies of novel Schiff base complexes: theoretical simulation studies on coronavirus (COVID-19) using molecular docking

“…In the spectrum of Cd(II) complex, doublet signals at 7.11 and 7.99 ppm were assigned for –CH protons of imidazole ring. The absence of peak at around 3.5 ppm assigned to –NH 2 group indicated desired product formation [ 25 ]. The multiple signals from 2.51 to 3.71 ppm correspond to CH 2 protons of ethylene moiety in the free Schiff base ligand [ 20 ].…”

Metal complexes of Tridentate Schiff base: Synthesis, Characterization, Biological Activity and Molecular Docking Studies with COVID‐19 Protein Receptor

“…In the aliphatic region, the ligand spectrum showed overlapping singlet signals observed at 2.26-3.13 ppm assigned to methyl protons (s, 12H, 4CH3) [6,11,15]. The absence of peak at around 4 ppm assigned to -NH2 group indicated most wanted product formation [16].…”

Synthetic methodologies and pharmacological applications of sulphonamide containing Schiff bases and their metal complexes: A comprehensive review

“…The nickel complexes were found to be more active against E. coli and P. aeruginosa in the range of 14-16 mm of a zone of inhibition (Figure 21). 32 Elsamra and co-workers synthesized a novel Schiff base ligand refluxing sulphanilamide with substituted aromatic aldehyde with a small amount of acetic acid as a catalyst for 5-8 h at 150 • C. An aqueous solution of Ni(NO 3 ) 2 .6H 2 O was refluxed with the hot ethanolic solution of ligand with continuous stirring for 2 h at 70 • C and to the reaction mixture, a small amount of ammonia solution was added to maintain the pH to 8. The antimicrobial efficiency was determined against E. coli, B. subtilis and A. fumigatus using a Microdilution broth assay.…”