Synthesis of new pyrrolo[2,3-d]pyrimidine derivatives as antibacterial and antifungal agents

Hilmy, K. M. H.; Khalifa, Maha M.; Hawata, Mohammed Abd Allah; Keshk, Reda Mohammed; El-Torgman, Abd Almeneam

doi:10.1016/j.ejmech.2010.08.043

Cited by 92 publications

(21 citation statements)

References 14 publications

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“…Construction of pyrimidine structure from 2-amino-3-cyanopyrrole derivative. Adapted from [110]. Fig.…”

Section: Modification and Addition Of Functional Groups In Existing Pmentioning

confidence: 96%

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Living on pyrrolic foundations – Advances in natural and artificial bioactive pyrrole derivatives

Domagala

Jarosz

Łapkowski

2015

European Journal of Medicinal Chemistry

123

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“…Construction of pyrimidine structure from 2-amino-3-cyanopyrrole derivative. Adapted from [110]. Fig.…”

Section: Modification and Addition Of Functional Groups In Existing Pmentioning

confidence: 96%

“…7) has been prepared to be used as antibacterial and antifungal agents, utilising the reaction of 1,5-disubtituted 2-amino-3-cyano-pyrroles with formamide, acetaldehyde, urea, acetamide [110].…”

Section: Modification and Addition Of Functional Groups In Existing Pmentioning

confidence: 99%

Living on pyrrolic foundations – Advances in natural and artificial bioactive pyrrole derivatives

Domagala

Jarosz

Łapkowski

2015

European Journal of Medicinal Chemistry

123

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“…Pyrrole nucleus has been gaining prominence due to the fact that its derivatives have been found to possess wide spectrum of activities like antibacterial[1], antifungal[2], antitubercular[3], and anticancer[4]. However, we have also reported substituted pyrrole derivatives as potent antibacterial and antitubercular agents[56].…”

mentioning

confidence: 99%

Synthesis, antimicrobial and cytotoxic activity of new heterocyclic hybrids based on 2,5-dimethylpyrrole and pyrrole scaffolds

Joshi

Kulkarni

2013

Indian J Pharm Sci

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A series of 4-(2,5-dimethylpyrrol-1-yl)/4-pyrrol-1-yl benzoic acid hydrazide analogs, some derived triazoles, azetidinones, thiazolidinones, and pyrroles have been synthesized in good yields and structures of these compounds were established by IR, 1H NMR, 13C NMR, mass spectral, and elemental analysis. These compounds were evaluated for their preliminary in vitro antibacterial, antifungal, and antitubercular activity against Mycobacterium tuberculosis H37 Rv strain by the broth dilution assay method. Twenty one of these compounds displayed good antimicrobial activity, with a MIC value of 1-4 μg/ml. Several compounds 4c, 8-10, 15b-15h, and 16b-16d exhibited good in vitro antitubercular activity with MIC value 1-2 μg/ml. Further, some title compounds were also assessed for their cytotoxic activity (IC50) against mammalian Vero cell lines and A549 (lung adenocarcinoma) cell lines using the MTT assay method. The results revealed that these compounds exhibit antitubercular activity at non-cytotoxic concentrations.

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“…[11][12][13][14] The 1,2,4-triazole fused chromen-2-one derivatives are valuable structural motifs present in avariety of functionalized molecules which have applied into organocatalysis and material science. 15 The triazole fused chromenone derivatives are found to possess wide range of biological activities such as anti-bacterial 17,26 , anti-inflammatory 18 , antiproliferative1, anti-cancer 19 , leishmanicidal agents 20 , antifungal 21 , epilepsy 22 , cycotic activity 23 , tyrosine kinase inhibitors 24 and diuretic 25 .…”

Section: Introductionmentioning

confidence: 99%

Biological Screening of 1,2,3-triazolyl substituted chromen-2-one derivatives

2017

IJMTER

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Abstract-The increasing incidence of bacterial and fungal resistance to a large number of antimicrobial agents has prompted studies on the development of new 1,2,3-triazolyl substituted chromen-2-one derivatives potential antimicrobial as well as antibacterial compounds. The molecular manipulation of promising lead compounds is still a major line of approach to develop new drugs. In this paper we are discussing about the anti-bacterial activity as well as anti-fungal activity of newly synthesized compounds 4a-l by cup plate method using nutrient agar medium, whereas anti-fungal activity by using potato-dextrose-agar medium.

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Synthesis of new pyrrolo[2,3-d]pyrimidine derivatives as antibacterial and antifungal agents

Cited by 92 publications

References 14 publications

Living on pyrrolic foundations – Advances in natural and artificial bioactive pyrrole derivatives

Living on pyrrolic foundations – Advances in natural and artificial bioactive pyrrole derivatives

Synthesis, antimicrobial and cytotoxic activity of new heterocyclic hybrids based on 2,5-dimethylpyrrole and pyrrole scaffolds

Biological Screening of 1,2,3-triazolyl substituted chromen-2-one derivatives

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