Until recently π-conjugated organic materials are based mainly on linear systems. Recent years, however, have brought about increasing interest in molecules boasting a dendritic, branched, or star-shaped architecture. This tendency is a direct result of the ongoing search for materials with progressively better properties. Such compounds, featuring novel, 3D architectures, exhibit a multitude of interesting qualities, making them stand out from well-known materials. The direction of star-shaped compound application is determined by whether they are able to form aggregates, π-stacks. This feature is a source of some astounding properties, coveted in numerous applications. Among this class of compounds high charge mobility, high fluorescence efficiency, and good charge separation are all found. Depending on the structure of the core, the molecule may adopt various types of symmetry. Similarly, the conjugation of orbitals may extend over the whole structure or be interrupted at chosen segments. The number of papers pertaining to star-shaped oligomers and polymers is ascending with each year, evidencing a growing interest in them. Consequently, this Review focuses particularly on the most recent reports concerning modification of the structure and properties of the aforementioned type of compounds, as well as on the development of devices based on them.
In the rapidly developing field of conjugated polymer science, the attribute of electrochromism these materials exhibit provides for a multitude of innovative application opportunities. Featuring low electric potential driven colour change, complemented by favourable mechanical and processing properties, an array of non-emissive electrochromic device (ECD) applications lays open ahead of them. Building up from the simplest two-colour cell, multielectrochromic arrangements are being devised, taking advantage of new electrochromic materials emerging at a fast pace. The ultimate device goal encompasses full control over the intensity and spectrum of passing light, including the two extremes of complete and null transmittance. With numerous electrochromic device architectures being explored and their operating parameters constantly ameliorated to pursue this target, a summary and overview of developments in the field is presented. Discussing the attributes of reported electrochromic systems, key research points and challenges are identified, providing an outlook for this exciting topic of polymer material science.
In a healthy female reproductive system, a subtle hormonal and metabolic dance leads to repetitive cyclic changes in the ovaries and uterus, which make an effective ovulation and potential implantation of an embryo possible. However, that is not so in the case of polycystic ovary syndrome (PCOS), in which case the central mechanism responsible for entraining hormonal and metabolic rhythms during the menstrual cycle is notably disrupted. In this review we provide a detailed description of the possible scenario of PCOS pathogenesis. We begin from the analysis of how a set of genetic disorders related to PCOS leads to particular malfunctions at a molecular level (e.g., increased enzyme activities of cytochrome P450 (CYP) type 17A1 (17α-hydroxylase), 3β-HSD type II and CYP type 11A1 (side-chain cleavage enzyme) in theca cells, or changes in the expression of aquaporins in granulosa cells) and discuss further cellular- and tissue-level consequences (e.g., anovulation, elevated levels of the advanced glycation end products in ovaries), which in turn lead to the observed subsequent systemic symptoms. Since gene-editing therapy is currently out of reach, herein special emphasis is placed on discussing what kinds of drug targets and which potentially active substances seem promising for an effective medication, acting on the primary causes of PCOS on a molecular level.
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