Synthesis of new pyrazoles and pyrozolo [3,4-b] pyridines as anti-inflammatory agents by inhibition of COX-2 enzyme

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“…Thus, according to 1 H NMR spectra, the number of protons in the spectra confirmed the structure. 13 C NMR spectra revealed three aliphatic and 18 aromatic carbons. Thus, 13 C NMR confirmed the number of carbons.…”

“…13 C NMR spectra revealed three aliphatic and 18 aromatic carbons. Thus, 13 C NMR confirmed the number of carbons. Hence, NMR spectra confirm the structure of 3n.…”

“…Pyrazoles with the five-member ring can occur in the structure of numerous biologically active compounds [10][11][12], which has made it an important bio-active drug target. This drug targets have been utilized as analgesic, antianxiety, anti-inflammatory and antipyretic agents [13]. Similar to pyrazole derivatives, 2, 4-Dihy dro-3H-pyrazol-3-one derivatives such as 4, 4'-(ary lmethylene)-bis (3-methyl-1-phenyl-1H-pyrazol-5-ols) have exhibited efficient biological properties among which antibacterial [14], gastric secretion stimulatory [15], antidepressant [16], antipyretic [17], antiinflammatory [18], and antifilarial features can be mentioned [19].…”

Synthesis and biological evaluation of pyrazolone analogues as potential anti‐inflammatory agents targeting cyclooxygenases and 5‐lipoxygenase

“…Compounds 3f , 3h , 3l , and 3p were evaluated for their in vivo AI activity by applying the carrageenan‐induced rat paw edema screening protocol as an acute inflammation model [ 42 ] according to a previously reported method after oral administration of a dose of 10 mg/kg of tested compounds as well as reference drugs. [ 40,43,44 ] The rats were marked and divided into eight experimental groups of six rats each. The first group received 1 ml saline and served as untreated control.…”

Novel synthesis of pyrazole-containing thiophene, 2-alkyloxy-pyridine and thieno[2,3-d]pyrimidine scaffolds as analgesic agents

“…Moreover, pyrazole-based heterocycles as thiophenes, 2-alkyloxypyridines and thieno [2,3-d]pyrimidines have been given more attention due to their useful therapeutic fields including, muscle relaxing, antitumor, anti-depressant, antimicrobial, antidiabetic, antitubercular, antioxidant, HIV reverse transcriptase inhibitors and also possess significant vasodilation activities [11][12][13][14][15][16][17]. They also demonstrated strong anti-inflammatory action with low GIT toxicity and analgesic impacts [18][19][20][21][22][23][24]. In the same way, and in the continuing work on synthesis of biologically active heterocycles based pyrazoles [25][26][27][28][29], we focused in this study on designing of new molecules carrying pyrazole substituents as hybrids with various heterocycles aiming to get potent candidates with analgesic properties.…”