Synthesis of new ketocyanine dyes for the development of optical sensors

Keto-polymethines: a versatile class of dyes with outstanding spectroscopic properties for in cellulo and in vivo two-photon microscopy imaging

“…9 These chromophores were then used as pH sensors in integrated waveguide devices, 10 and as NIR electrochemical fluorescence switches. 11 Surprisingly, the exploration of their potential for bio-imaging applications is scarce.…”

Effective Tuning of Ketocyanine Derivatives through Acceptor Substitution

“…Cyanines and merocyanines are both dye molecules that are known for their intense absorption features, but differ in their delocalization of electron density in that it is symmetrical in the former structures, while it is asymmetrical because of the donor–acceptor‐like features in the latter (Figure 1 a and b). 1–6A third class of molecules, ketocyanines (Figure 1 c), has features that resemble both the cyanines and the merocyanines 7–11. The charge transfer resonance forms of the ketocyanines clearly resemble the symmetrical electronic delocalization of cyanines, while the donor–acceptor functional group feature is merocyanine‐like.…”

“…[1][2][3][4][5][6] A third class of molecules, ketocyanines ( Figure 1c), has features that resemble both the cyanines and the merocyanines. [7][8][9][10][11] The charge transfer resonance formso ft he ketocyanines clearly resemble the symmetrical electronic delocalization of cyanines, while the donor-acceptor functional group feature is merocyanine-like. We were interested in identifying whether it is possible to predictably bias the ketocyanine-type molecules to exhibit either of thesec haracteristics.W ep resent our initial findings here.It is reasonablet oa scertain that the electronic delocalization in ketocyanines will depend on the donor functional group's ability to stabilizet he positive charge ( Figure 2a).…”

Functional Dyes, and Some Hi‐Tech Applications

“…Consequently, there has been an increase in the use of pH-sensitive fluorescent probes for intracellular studies [143]. In this interest, the use of cyanine dyes as fluorescent pH sensor has been growing [144][145][146].…”