Synthesis of Iron Oxide Nanoclusters by Thermal Decomposition

Никитин, А. А.; Щетинин, И. В.; Tabachkova, N. Yu.; Soldatov, Mikhail A.; Солдатов, А. В.; Sviridenkova, Natalya V.; Белоглазкина, Е. К.; Savchenko, Alexander; Fedorova, N.D.; Abakumov, Maxim; Majouga, Alexander G.

doi:10.1021/acs.langmuir.8b00753

Cited by 33 publications

(17 citation statements)

References 51 publications

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“…The synthesis and detailed physicochemical characterization of Pluronic F-127-modified MNCb and MNCl have been previously described [ 38 , 39 ]. Data on core/hydrodynamic size, relaxation rate, and surface charge of studied IONPs are summarized in Figure 1 , Figure S1 , and Table 1 .…”

Section: Resultsmentioning

confidence: 99%

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Biodistribution and Tumors MRI Contrast Enhancement of Magnetic Nanocubes, Nanoclusters, and Nanorods in Multiple Mice Models

Naumenko

Garanina

Никитин

et al. 2018

Contrast Media & Molecular Imaging

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Magnetic resonance imaging (MRI) is a powerful technique for tumor diagnostics. Iron oxide nanoparticles (IONPs) are safe and biocompatible tools that can be used for further enhancing MR tumor contrasting. Although numerous IONPs have been proposed as MRI contrast agents, low delivery rates to tumor site limit its application. IONPs accumulation in malignancies depends on both IONPs characteristics and tumor properties. In the current paper, three differently shaped Pluronic F-127-modified IONPs (nanocubes, nanoclusters, and nanorods) were compared side by side in three murine tumor models (4T1 breast cancer, B16 melanoma, and CT26 colon cancer). Orthotopic B16 tumors demonstrated more efficient IONPs uptake than heterotopic implants. Magnetic nanocubes (MNCb) had the highest r2-relaxivity in vitro (300 mM−1·s−1) compared with magnetic nanoclusters (MNCl, 104 mM−1·s−1) and magnetic nanorods (MNRd, 51 mM−1·s−1). As measured by atomic emission spectroscopy, MNCb also demonstrated better delivery efficiency to tumors (3.79% ID) than MNCl (2.94% ID) and MNRd (1.21% ID). Nevertheless, MNCl overperformed its counterparts in tumor imaging, providing contrast enhancement in 96% of studied malignancies, whereas MNCb and MNRd were detected by MRI in 73% and 63% of tumors, respectively. Maximum MR contrasting efficiency for MNCb and MNCl was around 6-24 hours after systemic administration, whereas for MNRd maximum contrast enhancement was found within first 30 minutes upon treatment. Presumably, MNRd poor MRI performance was due to low r2-relaxivity and rapid clearance by lungs (17.3% ID) immediately after injection. MNCb and MNCl were mainly captured by the liver and spleen without significant accumulation in the lungs, kidneys, and heart. High biocompatibility and profound accumulation in tumor tissues make MNCb and MNCl the promising platforms for MRI-based tumor diagnostics and drug delivery.

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Section: Resultsmentioning

confidence: 99%

“…MNCb and MNCl were synthesized as previously described [ 38 , 39 ]. MNRd were synthesized by two-step method.…”

Section: Methodsmentioning

confidence: 99%

Biodistribution and Tumors MRI Contrast Enhancement of Magnetic Nanocubes, Nanoclusters, and Nanorods in Multiple Mice Models

Naumenko

Garanina

Никитин

et al. 2018

Contrast Media & Molecular Imaging

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“…IO-cubes and IO-clusters were synthetized and functionalized as previously described [64,65]. The physicochemical properties of the IO-cubes and IO-clusters investigated in this study are summarized in Figs.…”

Section: Characterization Of the Nanoparticlesmentioning

confidence: 99%

Progressive lysosomal membrane permeabilization induced by iron oxide nanoparticles drives hepatic cell autophagy and apoptosis

et al. 2020

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Iron oxide nanoparticles (IONs) are frequently used in various biomedical applications, in particular as magnetic resonance imaging contrast agents in liver imaging. Indeed, number of IONs have been withdrawn due to their poor clinical performance. Yet comprehensive understanding of their interactions with hepatocytes remains relatively limited. Here we investigated how iron oxide nanocubes (IO-cubes) and clusters of nanocubes (IO-clusters) affect distinct human hepatic cell lines. The viability of HepG2, Huh7 and Alexander cells was concentration-dependently decreased after exposure to either IO-cubes or IO-clusters. We found similar cytotoxicity levels in three cell lines triggered by both nanoparticle formulations. Our data indicate that different expression levels of Bcl-2 predispose cell death signaling mediated by nanoparticles. Both nanoparticles induced rather apoptosis than autophagy in HepG2. Contrary, IO-cubes and IO-clusters trigger distinct cell death signaling events in Alexander and Huh7 cells. Our data clarifies the mechanism by which cubic nanoparticles induce autophagic flux and the mechanism of subsequent toxicity. These findings imply that the cytotoxicity of ION-based contrast agents should be carefully considered, particularly in patients with liver diseases.

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“…In addition to the polyol method and solvothermal synthesis, other synthetic methods have been explored for the production of iron oxide nanoclusters in a single step, such as thermal decomposition [17] and microwave irritation [18]. However, the quality of the nanoclusters has not been comparable to these two methods.…”

Section: Solvothermal Synthesismentioning

confidence: 99%

Preparation and Application of Iron Oxide Nanoclusters

2019

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Magnetic iron oxide nanoclusters, which refers to a group of individual nanoparticles, have recently attracted much attention because of their distinctive behaviors compared to individual nanoparticles. In this review, we discuss preparation methods for creating iron oxide nanoclusters, focusing on synthetic procedures, formation mechanisms, and the quality of the products. Then, we discuss the emerging applications for iron oxide nanoclusters in various fields, covering traditional and novel applications in magnetic separation, bioimaging, drug delivery, and magnetically responsive photonic crystals.

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Synthesis of Iron Oxide Nanoclusters by Thermal Decomposition

Cited by 33 publications

References 51 publications

Biodistribution and Tumors MRI Contrast Enhancement of Magnetic Nanocubes, Nanoclusters, and Nanorods in Multiple Mice Models

Biodistribution and Tumors MRI Contrast Enhancement of Magnetic Nanocubes, Nanoclusters, and Nanorods in Multiple Mice Models

Progressive lysosomal membrane permeabilization induced by iron oxide nanoparticles drives hepatic cell autophagy and apoptosis

Preparation and Application of Iron Oxide Nanoclusters

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