Biodistribution and Tumors MRI Contrast Enhancement of Magnetic Nanocubes, Nanoclusters, and Nanorods in Multiple Mice Models

Naumenko, Victor; Garanina, Anastasiia S.; Никитин, А. А.; Vodopyanov, Stepan S.; Vorobyeva, Nataliya S.; Tsareva, Y.; Kunin, Mikhail; Ilyasov, Artem; Semkina, Alevtina S.; Chekhonin, V. P.; Abakumov, Maxim; Majouga, Alexander G.

doi:10.1155/2018/8264208

Cited by 18 publications

(10 citation statements)

References 55 publications

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“…Elongated particles generally exhibit reduced cell uptake due to reduced formation of the actin cup which is an important prerequisite for phagocytosis by macrophages [ 46 ]. As an example, Naumenko et al compared the biodistribution profiles of nanocubes, nanoclusters, and nanorods coated with F-127 poloxamer [ 47 ]. Slower uptake of nanorods was observed in the liver and the spleen, compared to the two other systems, and was linked with lower sequestration by macrophages.…”

Section: Fundamental Characteristics Of Magnetic Nanoparticlesmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticles (SPION): From Fundamentals to State-of-the-Art Innovative Applications for Cancer Therapy

et al. 2023

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Despite significant advances in cancer therapy over the years, its complex pathological process still represents a major health challenge when seeking effective treatment and improved healthcare. With the advent of nanotechnologies, nanomedicine-based cancer therapy has been widely explored as a promising technology able to handle the requirements of the clinical sector. Superparamagnetic iron oxide nanoparticles (SPION) have been at the forefront of nanotechnology development since the mid-1990s, thanks to their former role as contrast agents for magnetic resonance imaging. Though their use as MRI probes has been discontinued due to an unfavorable cost/benefit ratio, several innovative applications as therapeutic tools have prompted a renewal of interest. The unique characteristics of SPION, i.e., their magnetic properties enabling specific response when submitted to high frequency (magnetic hyperthermia) or low frequency (magneto-mechanical therapy) alternating magnetic field, and their ability to generate reactive oxygen species (either intrinsically or when activated using various stimuli), make them particularly adapted for cancer therapy. This review provides a comprehensive description of the fundamental aspects of SPION formulation and highlights various recent approaches regarding in vivo applications in the field of cancer therapy.

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Section: Fundamental Characteristics Of Magnetic Nanoparticlesmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticles (SPION): From Fundamentals to State-of-the-Art Innovative Applications for Cancer Therapy

et al. 2023

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“…Three different morphologies of IONPs, namely, nanocubes (MNCb), nanoclusters (MNCl), and nanorods (MNRd) coated with block copolymers such as Pluronic‐F127 were studied in different mice models for their diagnostic and therapeutic functions. [ 163 ] Orthotopic B16 tumors more efficiently took up IONPs than heterotopic implants. MNCb demonstrated the highest transverse relaxivity in vitro and better delivery efficacy to tumors.…”

Section: Metal‐based Mri Contrast Agentsmentioning

confidence: 99%

Metal‐Based Nanoparticle Magnetic Resonance Imaging Contrast Agents: Classifications, Issues, and Countermeasures toward their Clinical Translation

Antwi-Baah

Wang

Chen

et al. 2022

Adv Materials Inter

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Over the years, several imaging techniques have been developed to improve alreadyexisting ones, thus, overcoming the obstacles that previous ones failed to overcome. Recently, much energy has been put into developing tools that complement the ability of the current imaging techniques. Imaging probe or contrast agent is one of the well-known tools in this category, which enhance the conspicuousness of images. Researchers have taken the opportunity to work tirelessly on developing imaging probes, which have gone a long way in attaining biological and functional image details of a biological system when used alongside existing imaging techniques. With the advantage of displaying a more detailed view for analyzing biological information and diagnosing diseases, imaging probes are undoubtedly a significant research field in biological and medical sciences.Molecular imaging, a term describing the visualization of specific molecules and molecular transformations that occur during disease activity in a living system using radiological and nuclear medicine, [2] has recently received enormous attention. A tissue or organ is diseased when it depicts characteristics that deviate from its normal functionality or organization. The diseased condition is stimulated by many biochemical processes involving internal and external stimuli from within the cell. Molecular imaging serves as a diagnostic tool for detecting abnormal disease molecules early because it can examine the biochemical adjustments as a normal tissue mutates into a diseased one. Representative imaging techniques include magnetic particle imaging (MPI), [3] positron emission tomography (PET), single-photon emission computed tomography (SPECT), optical imaging, magnetic resonance imaging (MRI), computed tomography (CT) and, ultrasound. [4] These imaging techniques are noninvasive diagnostic platforms that bridge the gap between molecular biology and molecular medicine. They allow examining a living organism to verify effects on multiple organ systems in vivo and help diagnose diseases at preclinical stages. These imaging techniques employ tracers or contrast agents to improve sensitivity. MPI is a tracer imaging modality that instantaneously quantifies the concentration and Metal-based nanoparticles, especially gadolinium, manganese, and iron, have gained ground in the research of magnetic resonance imaging (MRI) contrast agents. Over the years, contrast agents based on these paramagnetic and superparamagnetic nanomaterials have merited keen attention in the biomedical field due to their desired properties such as sizeable magnetic susceptibility, tunable size, easy surface functionalization, low toxicity, etc. Gadolinium-based chelates are the traditional MRI contrast agents in the clinic but require improved relaxivities and pharmacokinetics. Nanoparticles possess a larger surface area, demonstrate a longer retention time in the body, and allow the conjugation of several functional molecules to enhance tumor targeting, making them more advantageous. The pursuit o...

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“…It opens more prospects for the use of such NPs to improve the efficiency of magnetic resonance imaging (MRI) of various diseases and magnetic hyperthermia of solid tumors . Furthermore, such NPs are distinguished by a completely different cellular uptake and circulation time within the blood vessels, , which can be used to develop specific nanocarriers for addressing therapeutic molecules to target cells or various organs. On the other hand, it is known that the doping of the iron oxide lattice with various ions, i.e., introducing crystal anisotropy, allows to significantly change and improve the structural and magnetic properties of the resulting material.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Anisotropic Rod-Shaped CoFe₂O₄ Nanoparticles for Magnetic Resonance Imaging and Magnetomechanical Therapy

Nikitin,

Arkhipov,

Chmelyuk

et al. 2023

ACS Appl. Nano Mater.

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One-dimensional magnetic nanomaterials, such as nanorods, are one of the most interesting but unexplored objects due to the complexity of their manufacture. In this work, we report on the template-assisted preparation of rod-shaped cobalt ferrite (CoFe 2 O 4 ) nanoparticles (NPs) using the akaganeite (β-FeOOH) matrix and their application as multifunctional agents in biomedicine. In the beginning, rod-shaped β-FeOOH NPs are prepared by a forced hydrolysis technique. Then, amorphous Co(OH) 2 is deposited onto the surface of β-FeOOH. Finally, a solid-state reaction results in mesoporous rodshaped (130 nm × 40 nm) CoFe 2 O 4 NPs with a crystallite size of 7 nm. The proposed mechanism of synthesis involves the simultaneous transformation of β-FeOOH and amorphous Co(OH) 2 in two corresponding oxides during annealing, resulting in cation interdiffusion with the formation of a CoFe 2 O 4 phase, while the key role of the Co(OH) 2 shell in preserving the rod-shaped morphology of CoFe 2 O 4 NPs is demonstrated. NPs exhibit a high coercivity of 73 kA m −1 arising from their shape anisotropy, while their effective anisotropy constant of 1.1 × 10 5 J m −3 is compared to bulk CoFe 2 O 4 . Despite the low value of saturation magnetization (13 A m 2 kg −1 ), NPs demonstrate dual-modal relaxivity in MRI experiments with high values of r 1 = 2.3 s −1 mM −1 and r 2 = 228 s −1 mM −1 . Finally, we show that the magnetomechanical stimulus from NPs leads to the programmed death of breast cancer cells. Under the action of a low-frequency magnetic field (31 Hz), such NPs mediate mechanical vibrations, leading to cancer cell destruction even at a very low concentration of 6 μg CoFe 2 O 4 •mL −1 .

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Biodistribution and Tumors MRI Contrast Enhancement of Magnetic Nanocubes, Nanoclusters, and Nanorods in Multiple Mice Models

Cited by 18 publications

References 55 publications

Superparamagnetic Iron Oxide Nanoparticles (SPION): From Fundamentals to State-of-the-Art Innovative Applications for Cancer Therapy

Superparamagnetic Iron Oxide Nanoparticles (SPION): From Fundamentals to State-of-the-Art Innovative Applications for Cancer Therapy

Metal‐Based Nanoparticle Magnetic Resonance Imaging Contrast Agents: Classifications, Issues, and Countermeasures toward their Clinical Translation

Multifunctional Anisotropic Rod-Shaped CoFe₂O₄ Nanoparticles for Magnetic Resonance Imaging and Magnetomechanical Therapy

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Biodistribution and Tumors MRI Contrast Enhancement of Magnetic Nanocubes, Nanoclusters, and Nanorods in Multiple Mice Models

Cited by 18 publications

References 55 publications

Superparamagnetic Iron Oxide Nanoparticles (SPION): From Fundamentals to State-of-the-Art Innovative Applications for Cancer Therapy

Superparamagnetic Iron Oxide Nanoparticles (SPION): From Fundamentals to State-of-the-Art Innovative Applications for Cancer Therapy

Metal‐Based Nanoparticle Magnetic Resonance Imaging Contrast Agents: Classifications, Issues, and Countermeasures toward their Clinical Translation

Multifunctional Anisotropic Rod-Shaped CoFe2O4 Nanoparticles for Magnetic Resonance Imaging and Magnetomechanical Therapy

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Product

Resources

About

Multifunctional Anisotropic Rod-Shaped CoFe₂O₄ Nanoparticles for Magnetic Resonance Imaging and Magnetomechanical Therapy