Synthesis of Homopolymers and Copolymers

Slugovc, Christian

doi:10.1002/9783527674107.ch27

Cited by 9 publications

(9 citation statements)

References 219 publications

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“…ROMP initiated by Grubbs third generation ruthenium-benzylidene catalyst has been regarded as a powerful tool for the synthesis of graft-through nanoscopic brush architectures with a predictable number average molecular weight, Mn, and a narrow molecular weight distribution, Ð (Scheme 1; Box 1) [136,137]. Triphenylphosphonium ligands have emerged as economically and synthetically accessible mitochondrial-targeting systems that can be accessed from alkyl-halides via a substitution reaction using PPh 3 as the nucleophile in a pre-polymerization step [138,139].…”

Section: Structural Components Of the Bbbmentioning

confidence: 99%

Approaches to CNS Drug Delivery with a Focus on Transporter-Mediated Transcytosis

Razzak

Florence

Gunn-Moore

2019

IJMS

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Drug delivery to the central nervous system (CNS) conferred by brain barriers is a major obstacle in the development of effective neurotherapeutics. In this review, a classification of current approaches of clinical or investigational importance for the delivery of therapeutics to the CNS is presented. This classification includes the use of formulations administered systemically that can elicit transcytosis-mediated transport by interacting with transporters expressed by transvascular endothelial cells. Neurotherapeutics can also be delivered to the CNS by means of surgical intervention using specialized catheters or implantable reservoirs. Strategies for delivering drugs to the CNS have evolved tremendously during the last two decades, yet, some factors can affect the quality of data generated in preclinical investigation, which can hamper the extension of the applications of these strategies into clinically useful tools. Here, we disclose some of these factors and propose some solutions that may prove valuable at bridging the gap between preclinical findings and clinical trials.

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Section: Structural Components Of the Bbbmentioning

confidence: 99%

Approaches to CNS Drug Delivery with a Focus on Transporter-Mediated Transcytosis

Razzak

Florence

Gunn-Moore

2019

IJMS

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“…Ring-opening metathesis polymerization (ROMP) of monocyclic, bicyclic and polycyclic monomers with Ru complexes [276,277,278,279] unveiled polymerization methodologies capable to deliver unique materials not available by conventional polymerization techniques [280,281,282,283,284,285]. New types of telechelic and supramolecular polymers have been obtained by devising ruthenium catalysts suitable for their synthesis [286,287].…”

Section: Ruthenium Complexes In Catalysismentioning

confidence: 99%

Editorial of Special Issue Ruthenium Complex: The Expanding Chemistry of the Ruthenium Complexes

Drăguţan

Demonceau

2015

Molecules

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“…Ring-opening metathesis polymerization (ROMP) has become one of the most versatile polymerization techniques, finding application in many areas of polymer and materials research. − The ROMP of dicyclopentadiene (DCPD), a cheap byproduct in the C5 stream of naphtha crackers, is industrially relevant to fabricate, e.g., body panels for vehicles or cell covers for chloro-alkali plants, domestic wastewater treatment units, and large waste containers. − The thermoset poly(dicyclopentadiene) (pDCPD) is characterized by excellent mechanical properties with high toughness and rigidity and outstanding chemical resistance. The latter is ascribed to autoxidation of the surface of pDCPD .…”

Section: Introductionmentioning

confidence: 99%

Carbon Foams via Ring-Opening Metathesis Polymerization of Emulsion Templates: A Facile Method to Make Carbon Current Collectors for Battery Applications

Kovačič

Schafzahl

Matsko

et al. 2022

ACS Appl. Energy Mater.

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Polydicyclopentadiene (pDCPD), a thermoset with excellent mechanical properties, has enormous potential as a lightweight, tough, and stable matrix material owing to its highly cross-linked macromolecular network. This work describes generating pDCPD-based foams and hierarchically porous carbons derived therefrom by combining ring-opening metathesis polymerization (ROMP) of DCPD, high internal phase emulsions (HIPEs) as structural templates, and subsequent carbonization. The structure and function of the carbon foams were characterized and discussed in detail using scanning electron, transmission electron, or atomic force microscopy (SEM, TEM, AFM), electron energy-loss spectroscopy (TEM-EELS), N2 sorption, and analyses of electrical conductivity as well as mechanical properties. The resulting materials exhibited uniform, shape-retaining shrinkage of only ∼1/3 after carbonization. No structural failure was observed even when the pDCPD precursor foams were heated to 1400 °C. Instead, the high porosity, void size, and 3D interconnectivity were fully preserved, and the void diameters could be adjusted between 87 and 2.5 μm. Moreover, foams have a carbon content >97%, an electronic conductivity of up to 2800 S·m–1, a Young’s modulus of up to 2.1 GPa, and a specific surface area of up to 1200 m2·g–1. Surprisingly, the pDCPD foams were carbonized into shapes other than monoliths, such as 10’s of micron thick membranes or foamy coatings adhered to a metal foil or grid substrate. The latter coatings even adhere upon bending. Finally, as a use case, carbonized foams were applied as porous cathodes for Li–O2 batteries where the foams show a favorable combination of porosity, active surface area, and pore size for outstanding capacity.

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Synthesis of Homopolymers and Copolymers

Cited by 9 publications

References 219 publications

Approaches to CNS Drug Delivery with a Focus on Transporter-Mediated Transcytosis

Approaches to CNS Drug Delivery with a Focus on Transporter-Mediated Transcytosis

Editorial of Special Issue Ruthenium Complex: The Expanding Chemistry of the Ruthenium Complexes

Carbon Foams via Ring-Opening Metathesis Polymerization of Emulsion Templates: A Facile Method to Make Carbon Current Collectors for Battery Applications

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