Synthesis of hollow mesoporous silica nanoparticles with tunable shell thickness and pore size using amphiphilic block copolymers as core templates

Zhou, Xiaojun; Cheng, Xingxing; Feng, Wei; Qiu, Kexin; Chen, Liang; Nie, Wei; Yin, Zhiqi; Mo, Xiumei; Wang, Hongsheng; He, Chuanglong

doi:10.1039/c4dt01138d

Cited by 39 publications

(25 citation statements)

References 43 publications

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“…Afterwards, dialysis with an MWCO 12-14 kDa membrane and freeze-drying took place to obtain the final solution. In the second step, a structure was formed by coating a thickness-controlled PNS layer on each sSiO 2 using CTAB as the organic co-templates [28]. The core@shell structure was denoted as sSiO 2 /SiO 2 /CTAB.…”

Section: Preparation Of Hmsnsmentioning

confidence: 99%

The Engineering of Porous Silica and Hollow Silica Nanoparticles to Enhance Drug-loading Capacity

et al. 2019

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As a promising candidate for expanding the capacity of drug loading in silica nanoplatforms, hollow mesoporous silica nanoparticles (HMSNs) are gaining increasing attention. In this study, porous nanosilica (PNS) and HMSNs were prepared by the sol-gel method and template assisted method, then further used for Rhodamine (RhB) loading. To characterize the as-synthesized nanocarriers, a number of techniques, including X-ray diffraction (XRD), transmission electron microscopy (TEM), nitrogen absorption-desorption isotherms, dynamic light scattering (DLS), thermogravimetric analysis (TGA), and Fourier transform infrared spectroscopy (FTIR) were employed. The size of HMSN nanoparticles in aqueous solution averaged 134.0 ± 0.3 nm, which could be adjusted by minor changes during synthesis, whereas that of PNS nanoparticles was 63.4 ± 0.6 nm. In addition, the encapsulation of RhB into HMSN nanoparticles to form RhB-loaded nanocarriers (RhB/HMSN) was successful, achieving high loading efficiency (51.67% ± 0.11%). This was significantly higher than that of RhB-loaded PNS (RhB/PNS) (12.24% ± 0.24%). Similarly, RhB/HMSN also possessed a higher RhB loading content (10.44% ± 0.02%) compared to RhB/PNS (2.90% ± 0.05%). From those results, it is suggested that prepared HMSN nanocarriers may act as high-capacity carriers in drug delivery applications.

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Section: Preparation Of Hmsnsmentioning

confidence: 99%

The Engineering of Porous Silica and Hollow Silica Nanoparticles to Enhance Drug-loading Capacity

et al. 2019

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“…A range of hollow mesostructured materials or hollow mesostructured organic–inorganic hybrid materials, which were synthesized via a diverse synthesis method, regardless of whether they were prepared by hard‐templating or soft‐templating or any other methodologies, have also been studied extensively . This article provides typical examples of the recent synthesis of hollow mesostructured hybrid materials based mainly on the authors' works.…”

Section: Preparation and Characterization Of Hollow Mesostructured Hymentioning

confidence: 99%

Hollow Mesoporous Functional Hybrid Materials: Fascinating Platforms for Advanced Applications

Park¹,

Ha²

2017

Adv Funct Materials

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Functionalized hollow nano-and microspheres containing both hollow and mesoporous structures are fascinating materials for a broad range of applications, such as nanoparticle collectors, catalysis, drug delivery systems, immobilization of biomolecules, and the adsorption and separation of gas and pollutants, because of their empty interior. These hollow mesoporous silica materials are synthesized mainly via soft-and hard-templating routes and are usually modified with a range of organic functional groups (SH, NH 2 , CN, CH 3 , CC, benzene, fluorine linked organoalkylsilanes, and ethane-, amine, benzene, and biphenyl-bridged silanes) to improve their performance in many applications. This article outlines the most advanced applications of silica-based and functionalized hollow mesoporous materials that are reported in the last 3 years (January 2014-June 2017). The high applicability of hollow materials in various fields is discussed, including drug delivery and cancer therapy, bioimaging, adsorption/separation, catalysis, thermal and electrical insulators, anticorrosion, sensors, fuel cells, proton conductors, membrane, optics, superhydrophobic surfaces, and fire safety.

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“…This strategy is considered as active targeted drug delivery. [31][32][33] Taking advantage of the core-shell and porous structure, drugs can be encapsulated inside the cores by modifying the inner surface of HMSNs and released gradually through mesopores on the outer surface. To overcome ADR in colorectal cancer, more robust nanocarriers with Paper Nanoscale 2 | J.…”

Section: Introductionmentioning

confidence: 99%

Overcoming acquired drug resistance in colorectal cancer cells by targeted delivery of 5-FU with EGF grafted hollow mesoporous silica nanoparticles

et al. 2015

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Acquired drug resistance (ADR) can be developed in colorectal cancer cells after 5-fluorouracil (5-FU) treatment and diminish the effectiveness of chemotherapy. In this work, acquired 5-FU resistance in the colorectal cancer cell line SW480 was obtained with the up-regulation of dihydropyrimidine dehydrogenase (DPYD) gene expression which can convert 5-FU to its inactive metabolite. To overcome ADR in colorectal cancer, hollow mesoporous silica nanoparticles (HMSNs) grafted with epidermal growth factor (EGF) were used as nanocarriers to deliver 5-FU to colorectal cancer cells with acquired drug resistance. The effect and mechanism of 5-FU loaded EGF grafted HMSNs (EGF-HMSNs-5-FU) in overcoming acquired drug resistance in SW480/ADR cells were studied. The EGF-HMSNs were demonstrated to be specifically internalized in EGFR overexpressed SW480/ADR cells via a receptor-mediated endocytosis and can escape from endo-lysosomes. The EGF-HMSNs-5-FU exhibited much higher cytotoxicity on SW480/ADR cells than HMSNs-5-FU and free 5-FU while the plain HMSNs did not show significant cytotoxicity. The mechanism of EGF-HMSNs-5-FU in overcoming drug resistance in SW480/ADR cells could be attributed to the specific internalization of EGF-HMSNs-5-FU in EGFR overexpressed cells which can lead to high intracellular drug accumulation and cause cell death through S phase arrest.

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Synthesis of hollow mesoporous silica nanoparticles with tunable shell thickness and pore size using amphiphilic block copolymers as core templates

Cited by 39 publications

References 43 publications

The Engineering of Porous Silica and Hollow Silica Nanoparticles to Enhance Drug-loading Capacity

The Engineering of Porous Silica and Hollow Silica Nanoparticles to Enhance Drug-loading Capacity

Hollow Mesoporous Functional Hybrid Materials: Fascinating Platforms for Advanced Applications

Overcoming acquired drug resistance in colorectal cancer cells by targeted delivery of 5-FU with EGF grafted hollow mesoporous silica nanoparticles

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