Synthesis of Graphene Quantum Dots Decorated With Se, Eu and Ag As Photosensitizer and Study of Their Potential to Use in Photodynamic Therapy

Roeinfard, M.; Zahedifar, M.; Darroudi, Majid; Zak, A. Khorsand; Sadeghi, Ehsan

doi:10.1007/s10895-020-02674-0

Cited by 19 publications

(8 citation statements)

References 37 publications

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“…Graphene undergoes an oxidation-reduction process to produce rGO and GO. The finding that graphene can be used as PSs in PDT and effectively kill cancer cells has been demonstrated in several studies [99,100]. Considering its capacity to absorb light in the NIR range, graphene has been the subject of extensive in vivo and in vitro studies into its potential use in cancer imaging and phototherapy [101,102].…”

Section: Graphene Graphene Oxide (Go) and Reduced Graphene Oxide (Rgo...mentioning

confidence: 99%

Recent developments in photodynamic therapy and its application against multidrug resistant cancers

Bhattacharya,

Mukhopadhyay,

Shivam

et al. 2023

Biomed. Mater.

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Recently, photodynamic therapy (PDT) has received a lot of attention for its potential use in cancer treatment. It enables the therapy of a multifocal disease with the least amount of tissue damage. The most widely used prodrug is 5-aminolevulinic acid (5-ALA), which undergoes heme pathway conversion to protoporphyrin IX, which acts as a photosensitizer (PS). Additionally, hematoporphyrin, bacteriochlorin, and phthalocyanine are also studied for their therapeutic potential in cancer. Unfortunately, not every patient who receives PDT experiences a full recovery. Resistance to different anticancer treatments is commonly observed. A few of the resistance mechanisms by which cancer cells escape therapeutics are genetic factors, drug-drug interactions, impaired DNA repair pathways, mutations related to inhibition of apoptosis, epigenetic pathways, etc. Recently, much research has been conducted to develop a new generation of PS based on nanomaterials that could be used to overcome cancer cells' multidrug resistance. Various metal-based, polymeric, lipidic nanoparticles, dendrimers, etc., have been utilized in the PDT application against cancer. This article discusses the detailed mechanism by which cancer cells evolve towards multidrug resistance as well as recent advances in PDT-based nanoparticles for use against multidrug-resistant cancers. 

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Section: Graphene Graphene Oxide (Go) and Reduced Graphene Oxide (Rgo...mentioning

confidence: 99%

Recent developments in photodynamic therapy and its application against multidrug resistant cancers

Bhattacharya,

Mukhopadhyay,

Shivam

et al. 2023

Biomed. Mater.

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“…Recently, due to the simplicity, cost-effectiveness, and one-step synthesis route method of the hydrothermal method, this method has been considered [ 25 ]. The hydrothermal method [ 97 , 98 , 99 ], microwave method [ 100 , 101 , 102 ], electrochemical oxidation method [ 103 , 104 , 105 ], the ultrasonic method [ 103 , 106 ], and biosynthesis methods [ 107 , 108 ] are among the methods used for bioactive GQDs synthesis based on top-down and bottom-up processes.…”

Section: Bioactivationmentioning

confidence: 99%

Bioactive Graphene Quantum Dots Based Polymer Composite for Biomedical Applications

et al. 2022

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Today, nanomedicine seeks to develop new polymer composites to overcome current problems in diagnosing and treating common diseases, especially cancer. To achieve this goal, research on polymer composites has expanded so that, in recent years, interdisciplinary collaborations between scientists have been expanding day by day. The synthesis and applications of bioactive GQD-based polymer composites have been investigated in medicine and biomedicine. Bioactive GQD-based polymer composites have a special role as drug delivery carriers. Bioactive GQDs are one of the newcomers to the list of carbon-based nanomaterials. In addition, the antibacterial and anti-diabetic potentials of bioactive GQDs are already known. Due to their highly specific surface properties, π-π aggregation, and hydrophobic interactions, bioactive GQD-based polymer composites have a high drug loading capacity, and, in case of proper correction, can be used as an excellent option for the release of anticancer drugs, gene carriers, biosensors, bioimaging, antibacterial applications, cell culture, and tissue engineering. In this paper, we summarize recent advances in using bioactive GQD-based polymer composites in drug delivery, gene delivery, thermal therapy, thermodynamic therapy, bioimaging, tissue engineering, bioactive GQD synthesis, and GQD green resuscitation, in addition to examining GQD-based polymer composites.

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“…First, doping GQDs with heteroatoms N, 123 Cl, 124 F, 125 Eu, Ag, and Se 126 is an effective method, which can change its electronic density and optical properties to improve ROS generation efficiency. Second, PS-doped GQDs could enhance PDT.…”

Section: Two-dimensional (2d) Scpsmentioning

confidence: 99%

Strategies to Improve Photodynamic Therapy Efficacy of Metal-Free Semiconducting Conjugated Polymers

Sun¹,

Xue²,

Zhang³

2022

IJN

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Photodynamic therapy (PDT) is a noninvasive therapy for cancer and bacterial infection. Metal-free semiconducting conjugated polymers (SCP S ) with good stability and optical and electrical properties are promising photosensitizers (PSs) for PDT compared with traditional small-molecule PSs. This review analyzes the latest progress of strategies to improve PDT effect of linear, planar, and three-dimensional SCP S , including improving solubility, adjusting conjugated structure, enhancing PS-doped SCPs, and combining therapies. Moreover, the current issues, such as hypoxia, low penetration, targeting and biosafety of SCP S, and corresponding strategies, are discussed. Furthermore, the challenges and potential opportunities on further improvement of PDT for SCPs are presented.

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Synthesis of Graphene Quantum Dots Decorated With Se, Eu and Ag As Photosensitizer and Study of Their Potential to Use in Photodynamic Therapy

Cited by 19 publications

References 37 publications

Recent developments in photodynamic therapy and its application against multidrug resistant cancers

Recent developments in photodynamic therapy and its application against multidrug resistant cancers

Bioactive Graphene Quantum Dots Based Polymer Composite for Biomedical Applications

Strategies to Improve Photodynamic Therapy Efficacy of Metal-Free Semiconducting Conjugated Polymers

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