Synthesis of glucose-responsive bioconjugated gel particles using surfactant-free emulsion polymerization

Design of molecule-responsive organic–inorganic hybrid nanoparticles bearing cyclodextrin as ligands

“…For example, we reported that it took comparable time for glucose-responsive bulk hydrogels to reach equilibrium in a swollen state in response to the target glucose, while glucose-responsive gel particles with a diameter of 750 nm swelled rapidly to attain an equilibrium swelling ratio in a buffer solution with glucose. 18 As described in the previous section, we succeeded in preparing CD-PAAm/SiO 2 nanoparticles with a CD-containing hydrogel layer on the surface of SiO 2 nanoparticles. Thus, we investigated the BPA-responsive behavior of CD-PAAm/SiO 2 nanoparticles in the presence of BPA.…”

“…8 We have proposed a novel strategy for the preparation of moleculeresponsive hydrogel 9-17 and gel particles. 18 The stimuli-responsive behavior of most hydrogels reported previously was mainly based on changes in the hydrophilicity of polymer chains or in charged groups induced by pH and temperature changes. In contrast to the standard strategies for the preparation of stimuli-responsive hydrogels, our strategy utilizes molecular complexes as dynamic crosslinks that dissociate and associate in the presence and absence of a target molecule, respectively.…”

Biologically Stimuli‐Responsive Hydrogels

“…Rapid response to a change in the glucose concentration was achieved by synthesizing submicron-sized gel particles with GEMA-ConA complexes as dynamic crosslinks. The ConA-copolymerized gel particles with a submicron size were synthesized by surfactant-free emulsion copolymerization of N,Ndiethylaminoethyl methacrylate (DEAEMA), poly(ethylene glycol) dimethacrylate (PEGDMA), GEMA, and acryloyl ConA [51]. In standard emulsion polymerizations, surfactants are generally used to stabilize and disperse monomer emulsions and particles in water.…”

Design of nano- and micro-structured molecule-responsive hydrogels

“…Therefore, glucose-responsive gel particles with saccharide-lectin complexes as dynamic crosslinks were prepared 20 . In general, stimuli-responsive gel particles were prepared by emulsion polymerization using surfactants for stabilization of the monomer emulsions and the resulting particles in water.…”

“…The present paper provides an overview of our studies on the nano-and micro-structured molecule-responsive hydrogels prepared by utilizing various polymerization techniques, such as photopolymerization 15 , surface-initiated atom transfer radical polymerization (SI-ATRP) [16][17][18][19] , and soap-free emulsion polymerization 20 . The nano-and micro-structured molecule-responsive hydrogel provides not only rapid responsiveness but also highly selective and sensitive detection of target molecules when combined with sensing devices [16][17][18] .…”