Biologically Stimuli‐Responsive Hydrogels

Kawamura, Akifumi; Miyata, Takashi

doi:10.1002/9781118680469.ch10

Cited by 2 publications

(3 citation statements)

References 74 publications

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“…− ions to mediate the synthesis of gold NPs. 23,24 Interactions between HAuCl 4 and the H4 core were evidenced by 1 H NMR experiments in D 2 O solution: the addition of HAuCl 4 to a neutral polymer induced a shift in chemical shifts only for protons of primary and tertiary amines (an upfield shift for NCH 2 CH 2 NH 2 and a downfield shift for CH 2 NH 2 ; Figure SI13 in SI). Thus, with H4P7, metal ions can be coordinated to the polymer tertiary amine and free primary amine functions.…”

Section: Transmission Electron Microscopy (Tem)mentioning

confidence: 99%

“…The observation of various systems where such processes occur enables the design of stimuli-responsive hydrogels (i.e., temperature, pH, light,...) in a controllable and predictable fashion. In response to these external stimuli, these hydrogels have the ability to change their properties drastically (i.e., dimensions, structures, interactions, viscosity,...) and therefore have been applied as biomaterials, drug-delivery systems, or in catalysis. , In most cases, physically or chemically cross-linked polymer chains are involved. Of special interest are thermoresponsive hydrogels: a small temperature change around a critical value induces the collapse or expansion of polymer chains as a response to adjustments in the interactions between the polymer chains and the aqueous media.…”

Section: Introductionmentioning

confidence: 99%

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Thermoresponsive Properties of PNIPAM-Based Hydrogels: Effect of Molecular Architecture and Embedded Gold Nanoparticles

et al. 2015

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Thermoresponsive hydrogels were successfully prepared from poly(N-isopropylacrylamide)-based polymers with different architectures (linear, branched, or hyperbranched). The macromolecular architectures strongly influence the internal structure of the hydrogels, therefore modulating their thermoresponsive and rheological properties. These hydrogels were used for the in situ synthesis of gold nanoparticles. Significant changes in hydrogel microstructures and in average pore size due to the presence of gold nanoparticles were observed. Additionally, their presence significantly increases both the mechanical strength and the toughness of the hydrogel networks.

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Section: Transmission Electron Microscopy (Tem)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Thermoresponsive Properties of PNIPAM-Based Hydrogels: Effect of Molecular Architecture and Embedded Gold Nanoparticles

et al. 2015

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“…As a result, the pH decreases within the structure of the hydrogel, ionization of specific cationic functional groups occurs, swelling of the hydrogel and penetration of insulin into the bloodstream. 4,114,179,180 In the cellular and intracellular environment, the fundamental role in activation and regulation processes is played by enzymes. The presence of enzymes and their activity varies depending on the cell or organ compartment, and there are also differences in enzymes activity between the pathological and physiological conditions.…”

Section: Biological Factorsmentioning

confidence: 99%

<p>Smart Hydrogels – Synthetic Stimuli-Responsive Antitumor Drug Release Systems</p>

Kasiński¹,

Zielińska–Pisklak²,

Olędzka³

et al. 2020

IJN

124

107

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Among modern drug formulations, stimuli-responsive hydrogels also called "smart hydrogels" deserve a special attention. The basic feature of this system is the ability to change their mechanical properties, swelling ability, hydrophilicity, bioactive molecules permeability, etc., influenced by various stimuli, such as temperature, pH, electromagnetic radiation, magnetic field and biological factors. Therefore, stimuli-responsive matrices can be potentially used in tissue engineering, cell cultures and technology of innovative drug delivery systems (DDSs), releasing the active substances under the control of internal or external stimuli. Moreover, smart hydrogels can be used as injectable DDSs, due to gel-sol transition connected with in situ cross-linking process. Innovative smart hydrogel DDSs can be utilized as matrices for targeted therapy, which enhances the effectiveness of tumor chemotherapy and subsequently limits systemic toxicity. External stimulus sensitivity allows remote control over the drug release profile and gel formation. On the other hand, internal factors provide drg accumulation in tumor tissue and reduce the concentration of active drug form in healthy tissue. In this report, we summarise the basic knowledge and chemical strategies for the synthetic smart hydrogel DDSs applied in antitumor therapy.

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Biologically Stimuli‐Responsive Hydrogels

Cited by 2 publications

References 74 publications

Thermoresponsive Properties of PNIPAM-Based Hydrogels: Effect of Molecular Architecture and Embedded Gold Nanoparticles

Thermoresponsive Properties of PNIPAM-Based Hydrogels: Effect of Molecular Architecture and Embedded Gold Nanoparticles

<p>Smart Hydrogels – Synthetic Stimuli-Responsive Antitumor Drug Release Systems</p>

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