Design of molecule-responsive organic–inorganic hybrid nanoparticles bearing cyclodextrin as ligands

Abstract

Novel organic-inorganic hybrid nanoparticles with a bisphenol A (BPA)-responsive hydrogel layer on the surface of SiO 2 nanoparticles were prepared via surface-initiated atom transfer radical polymerization of acrylamide (AAm), acryloyl-modified β-cyclodextrin (CD) and N, N′-methylenebisacrylamide. The resulting CD-PAAm/SiO 2 nanoparticles underwent a change in size in response to BPA. The BPA-responsive shrinkage of the CD-PAAm/SiO 2 nanoparticles was caused by an increase in the crosslinking density of the CD-PAAm hydrogel layer, which resulted from the formation of CD-BPA-CD complexes acting as dynamic crosslinks. The smart functions of BPA-responsive organic-inorganic hybrid nanoparticles can provide useful tools for constructing molecular sensors and adsorption materials.

Core–shell microgels having zwitterionic hydrogel core and temperature-responsive shell prepared via inverse miniemulsion RAFT polymerization

“…Particularly, stimuli-responsive core–shell microgels are of significant interest because they exhibit unique stimuli-responsive behaviour due to the different swelling/shrinkage properties of their core and shell networks. 6 The stimuli-responsive core–shell microgels have various fascinating applications, such as smart nanoreactors, 7,8 sensors 9,10 and smart drug carriers. 11,12 Conventional core–shell microgels are broadly divided into two classes: microgels composed of a hard-sphere core and a crosslinked hydrogel shell, and both core and shell crosslinked microgels.…”

“…For example, we synthesized a bisphenol A (BPA)-responsive core–shell microgel composed of a silica nanoparticle core and β-cyclodextrin (CD)-conjugated polyacrylamide hydrogel shell via surface-initiated atom transfer radical polymerization (ATRP). 10 The BPA-responsive core–shell microgels exhibited shrinkage in response to the target BPA due to the increase in the crosslinking density resulting from the formation of sandwich-like CD–BPA–CD complexes acting as dynamic crosslinks. The core–shell microgels comprising both hydrogel core and shell are conventionally synthesized via two-step precipitation polymerization.…”

Preparation of Molecule-Responsive Microsized Hydrogels via Photopolymerization for Smart Microchannel Microvalves

“…It also forms a complex with a phenol derivative such as BPA . Molecule‐responsive hydrogels that undergo volume changes in response to target BPA have been synthesized by molecular imprinting using CDs as ligands . These hydrogels shrank gradually in the presence of BPA because their cross‐linking density increased as a result of the formation of CD‐BPA‐CD complexes that acted as dynamic cross‐links.…”

“…[ 26 ] Molecule-responsive hydrogels that undergo volume changes in response to target BPA have been synthesized by molecular imprinting using CDs as ligands. [ 27,28 ] These hydrogels shrank gradually in the presence of BPA because their cross-linking density increased as a result of the formation of CD-BPA-CD complexes that acted as dynamic cross-links. However, they reached equilibrium over a long time upon BPA-responsive shrinking.…”

Design of nano- and micro-structured molecule-responsive hydrogels

“…Organic-inorganic hybrid nanoparticles with molecule-responsive hydrogel layers were also successfully prepared by utilizing SI-ATPR on the surface of silica nanoparticles (SiO 2 NPs) 19 .…”