Synthesis of Gingerol-loaded Uio-66 nanoparticles and its anti-cancer effect against gastric cancer cell line (AGS)

Kazazi, Irana; Ashrafi, Fatemeh; Malekloo, M.

doi:10.1007/s11033-022-07667-9

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…The formula used was, EE% = amount of drug obtained/total amount of drug added *100 as done in earlier studies. [18,19]…”

Section: Drug Encapsulation Efficiency Of Casein Nanoparticlesmentioning

confidence: 99%

“…The casein nanoparticle formed above were characterized for size, zeta potential and polydispersity index (PDI). [19] Size was measured by dynamic light scattering (DLS) with Zeta sizer, Nano series (Nano-ZS, Malvern, UK). Nanoparticles diameter and surface charge/ZP was mea-sured in water pH (6.2-7.4) at 25 • C with a scattering angle of 90 • C.…”

Section: Characterization Of Casein Nanoparticlesmentioning

confidence: 99%

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Evaluation of the cytotoxic activity of sorafenib‐loaded camel milk casein nanoparticles against hepatocarcinoma cells

Mittal,

Mahala,

Dhanawade

et al. 2024

Biotechnology Journal

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Sorafenib, a multikinase inhibitor is used to treat hepatocellular and renal carcinoma. However, a low solubility impedes its bioavailability and thus, effectiveness. This study aims to enhance its effectiveness by using novel camel milk casein nanoparticles as a delivery system. This study evaluates the cytotoxicity of sorafenib encapsulated in camel milk casein nanoparticles against human hepatocarcinoma cells (HepG2 cells) in vitro. Optimal drug loaded nanoparticles were stable for 1 month, had encapsulation efficiency of 96%, exhibited a particle size of 230 nm, zeta potential of −14.4 and poly disparity index of 0.261. Treatment with it led to cell morphology and DNA fragmentation as a characteristic of apoptosis. Flow cytometry showed G1 phase arrest of cell cycle and 26% increased apoptotic cells population upon treatment as compared to control. Sorafenib‐loaded casein nanoparticles showed 6‐fold increased ROS production in HepG2 cells as compared to 4‐fold increase shown by the free drug. Gene and protein expression studies done by qPCR and western blotting depicted upregulation of tumor suppressor gene p53, pro‐apoptotic Bax, and caspase‐3 along with downregulated anti‐apoptotic Bcl‐2 gene and protein expression which further emphasized death by apoptosis. It is concluded regarding the feasibility of these casein nanoparticles as a delivery system with enhanced therapeutic outcomes against hepatocellular carcinoma cells.

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“…The formula used was, EE% = amount of drug obtained/total amount of drug added *100 as done in earlier studies. [18,19]…”

Section: Drug Encapsulation Efficiency Of Casein Nanoparticlesmentioning

confidence: 99%

Section: Characterization Of Casein Nanoparticlesmentioning

confidence: 99%

Evaluation of the cytotoxic activity of sorafenib‐loaded camel milk casein nanoparticles against hepatocarcinoma cells

Mittal,

Mahala,

Dhanawade

et al. 2024

Biotechnology Journal

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Gingerols and shogaols: A multi-faceted review of their extraction, formulation, and analysis in drugs and biofluids to maximize their nutraceutical and pharmaceutical applications

Maghraby,

Labib,

Sobeh

et al. 2023

Food Chemistry: X

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Reproducibility in research into metal-organic frameworks in nanomedicine

Forgan

2024

Commun Mater

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Metal-organic frameworks (MOFs) are currently widely investigated for a number of potential biomedicinal applications, with particular focus on nanoscale drug delivery. Nanomedicine in general comes with specific challenges to ensure reproducibility of results, including batch-to-batch variations in ostensibly the same nanomaterial, differences in synthetic and analytical practices, intrinsic issues with in vitro culturing and assaying, and a lack of availability of raw data for comparative analysis. This perspective provides an overview of reproducibility issues in the context of MOFs in nanomedicine, covering their preparation and in vitro analysis. The commonly studied UiO-66 is used as an exemplar to highlight variability in synthetic and characterisation practices, as well as in the publication and availability of data. Some common roadblocks to reproducibility are highlighted, alongside suggestions and resources for best practice.

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Synthesis of Gingerol-loaded Uio-66 nanoparticles and its anti-cancer effect against gastric cancer cell line (AGS)

Cited by 3 publications

References 34 publications

Evaluation of the cytotoxic activity of sorafenib‐loaded camel milk casein nanoparticles against hepatocarcinoma cells

Evaluation of the cytotoxic activity of sorafenib‐loaded camel milk casein nanoparticles against hepatocarcinoma cells

Gingerols and shogaols: A multi-faceted review of their extraction, formulation, and analysis in drugs and biofluids to maximize their nutraceutical and pharmaceutical applications

Reproducibility in research into metal-organic frameworks in nanomedicine

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