Gingerols and shogaols: A multi-faceted review of their extraction, formulation, and analysis in drugs and biofluids to maximize their nutraceutical and pharmaceutical applications

Maghraby, Yasmin R.; Labib, Rola M.; Sobeh, Mansour; Farag, Mohamed A.

doi:10.1016/j.fochx.2023.100947

Cited by 6 publications

(4 citation statements)

References 68 publications

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“…The phytochemical analysis of Z. officinale led to the isolation of the pure bioactive compound 6-gingerol, which was confirmed by HPLC and TLC, and by comparison with literature data. 26 Natural products are a rich source of bioactive compounds for the treatment of various ailments. The compound 6-gingerol is the main biochemical marker of Z. officinale, it has been shown to have hypoglycemic properties in diabetic mice and improved impaired insulin signaling in arsenicintoxicated mice.…”

Section: Effect Of 6-gingerol On Percentage Fat Contentmentioning

confidence: 99%

Isolation of 6-Gingerol from the Rhizome of Zinger (Zingiber officinale) and Evaluation of its Effect on the Bone Health of Streptozotocin-Induced Diabetic Rats

2024

TJNPR

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There are two ways to assess obesity; Body mass index (BMI), and waist-to-hip ratio. While these two parameters are clinically significant, bone mineral density (BMD), bone mineral content (BMC), and fat mass assessments are more precise and critical clinical parameters. Various studies have confirmed the significance of bone mineral density in diabetes especially in elderly diabetic patients where lower bone mineral densities are reported to increase the risk of hip fracture. [12][13][14] The risk of fracture also increases in other skeletal sites, such as the proximal humerus, foot, and possibly ankle, in diabetes. 15 BMD fluctuations may not be associated with diabetes, but the risk of fracture increases secondary to peripheral neuropathy, 16 showing symptoms like poor gait, a tendency to fall, etc. Ginger (Zingiber officinale Rosc) is an aromatic plant belonging to the family Zingiberaceae, it is used as a flavouring agent in Indian food. The phytochemicals of ginger contribute to its health-promoting properties. The compound 6-gingerol is a non-volatile active constituent of ginger, with many pharmacological properties, including antidiabetic effect. According to Almatroodiet al. (2021), 17 6-gingerol decreases hyperlipidaemic markers, inflammation, and oxidative stress in diabetic rats, ultimately preventing kidney damage. It proved to be a breakthrough therapeutic agent for preventing kidney damage caused by diabetes mellitus. According to Alharbiet al. (2022), 18 gingerol do not only aids in the treatment of hyperglycemia but also shows effectiveness in related diseases. The efficacy of 6-gingerol in lowering serum total cholesterol, low-density lipoproteins (LDL), and very lowdensity lipoproteins (VLDL), as well as raising high density lipoprotein (HDL) in hyperglycemic rats fed a high-lipid diet in a diabetic rat model, has been observed. 19 According to Suzer et al. (2022), 20 ginger extract treatment of diabetic rats enhances bone health, and stop the effect of the disease on bone mechanical characteristics. Oxidative stress is a significant risk factor for diabetes and age-related chronic diseases such as osteoporosis. 21 Gingerols, shogaols, and other ketonephenolic derivatives contribute to ginger's antioxidative abilities. The study of Ajayiet al. (2019), 22 has shown that ginger extract reduces

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Section: Effect Of 6-gingerol On Percentage Fat Contentmentioning

confidence: 99%

Isolation of 6-Gingerol from the Rhizome of Zinger (Zingiber officinale) and Evaluation of its Effect on the Bone Health of Streptozotocin-Induced Diabetic Rats

2024

TJNPR

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“…is a plant used in food, medicine, and cosmetics. Due to the refreshing aroma and spicy, pungent taste, the addition of ginger rhizome enhances the sense of heat and has been widely used as a dietary supplement in traditional medicine ( Jang et al, 2004 , Koga et al, 2016 , Maghraby et al, 2023 ). Numerous studies have demonstrated ginger (Fam.…”

Section: Introductionmentioning

confidence: 99%

Developing the procedure-enhanced model of ginger-infused sesame oil based on its flavor and functional properties

Lin,

Chen,

Chen

et al. 2024

Food Chemistry: X

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“…Ginger, both fresh and dried, is used for consumption as well as medicinal applications [ 5 ]. Ginger’s extracts and essential oils have diverse chemical compositions, and they mainly include compounds belonging to terpenoids and phenolics groups which possesses significant biological activity [ 6 ]. Moreover, polysaccharides have also been reported to be components of ginger extracts [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…In the past years, new technologies for the extraction of beneficial compounds have attracted a lot of attention. Specifically, environmentally friendly, low-cost, and sustainable extraction methods have been used to extract and isolate compounds of interest [ 6 ]. Among them, super- and sub- critical extraction methods have aroused remarkable interest from the scientific community, because only small changes in the pressure and temperature can increase the selectivity of the extraction process [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Extraction of High Value Products from Zingiber officinale Roscoe (Ginger) and Utilization of Residual Biomass

Spyrou,

Batista,

Corazza

et al. 2024

Molecules

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Zingiber officinale Roscoe (ginger) is a plant from the Zingiberaceae family, and its extracts have been found to contain several compounds with beneficial bioactivities. Nowadays, the use of environmentally friendly and sustainable extraction methods has attracted considerable interest. The main objective of this study was to evaluate subcritical propane (scPropane), supercritical CO2 (scCO2), and supercritical CO2 with ethanol (scCO2 + EtOH) as co-solvent methods for the extraction of high value products from ginger. In addition, the reuse/recycling of the secondary biomass in a second extraction as a part of the circular economy was evaluated. Both the primary and the secondary biomass led to high yield percentages, ranging from 1.23% to 6.42%. The highest yield was observed in the scCO2 + EtOH, with biomass prior used to scCO2 extraction. All extracts presented with high similarities as far as their total phenolic contents, antioxidant capacity, and chemical composition. The most abundant compounds, identified by the two different gas chromatography-mass spectrometry (GC-MS) systems present, were a-zingiberene, β- sesquiphellandrene, a-farnesene, β-bisabolene, zingerone, gingerol, a-curcumene, and γ-muurolene. Interestingly, the reuse/recycling of the secondary biomass was found to be promising, as the extracts showed high antioxidant capacity and consisted of significant amounts of compounds with beneficial properties.

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Gingerols and shogaols: A multi-faceted review of their extraction, formulation, and analysis in drugs and biofluids to maximize their nutraceutical and pharmaceutical applications

Cited by 6 publications

References 68 publications

Isolation of 6-Gingerol from the Rhizome of Zinger (Zingiber officinale) and Evaluation of its Effect on the Bone Health of Streptozotocin-Induced Diabetic Rats

Isolation of 6-Gingerol from the Rhizome of Zinger (Zingiber officinale) and Evaluation of its Effect on the Bone Health of Streptozotocin-Induced Diabetic Rats

Developing the procedure-enhanced model of ginger-infused sesame oil based on its flavor and functional properties

Extraction of High Value Products from Zingiber officinale Roscoe (Ginger) and Utilization of Residual Biomass

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