Synthesis of controlled size starch nanoparticles (SNPs)

Gutiérrez, Gemma; Morán, Diana; Marefati, Ali; Purhagen, Jeanette; Rayner, Marilyn; Matos, María

doi:10.1016/j.carbpol.2020.116938

Cited by 49 publications

(27 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other researchers stated similar results. 16 , 83 , 84 The peaks of OH– stretching changed to a higher wavelength range for SNPs produced by alkalization and sonication procedures, according to Ahmad et al, 83 which was ascribed to the loss of the crystalline structure and exposure of the starch molecule’s –OH groups to the preparation process. 85 , 86 Furthermore, the intensity of the absorption peaks inside that wavelength is considerably less prominent for the SNPs in the FT-IR spectrums acquired in that study.…”

Section: Resultsmentioning

confidence: 96%

“…SNPs are prepared from starch, a renewable, biodegradable polymer created by many plants. 15,16 Another fascinating feature of SNPs is their ability to encapsulate various bioactive compounds. 17 SNPs were reported to enhance the water solubility and bioavailability of several poorly water-soluble drugs 14 like silibinin, 18 itraconazole, 19 lovastatin, 20 and curcumin.…”

Section: Introductionmentioning

confidence: 99%

“…By evaluating the variations in the semicrystalline and amorphous domains inside starch granules, FT-IR spectroscopy may be used to assess starch crystallinity. 16,83 The high peak intensity at 995 cm −1 with shoulders at 1018 cm −1 and 1047 cm −1 suggested amorphous and crystalline order of starch. SNPs showed a less pronounced peak compared to native starch signifying the loss of starch's crystalline structure and the formation of its amorphous phase.…”

mentioning

confidence: 96%

See 2 more Smart Citations

Starch Nanoparticles for Enhancement of Oral Bioavailability of a Newly Synthesized Thienopyrimidine Derivative with Anti-Proliferative Activity Against Pancreatic Cancer

Gardouh¹,

El-Din²,

Salem³

et al. 2021

DDDT

View full text Add to dashboard Cite

This research aimed to improve water solubility and oral bioavailability of a newly synthesized thienopyrimidine derivative (TPD) with anti-pancreatic cancer activity by loading on starch nanoparticles (SNPs). Methods: TPD was synthesized, purified and its ADME behavior was predicted using Swiss ADME software. A UV spectroscopy method was developed and validated to measure TPD concentration at various dosage forms. SNPs loaded with TPD (SNPs-TPD) were prepared, characterized for particle size, polydispersity index, zeta potential, transmission electron microscopy, Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), entrapment efficiency, in-vitro release, and in-vivo animal study. Results: The Swiss ADME results showed that TPD can be administered orally; however, it has low oral bioavailability (0.55) and poor water solubility. The significant regression coefficient of the calibration curve (r 2 = 0.9995), the precision (%RSD < 0.5%) and the accuracy (99.46−101.72%) confirmed the efficacy of the developed UV method. SNPs-TPD had a spherical monodispersed (PDI= 0.12) shape, nanoparticle size (22.98 ± 4.23) and good stability (−21 ± 4.72 mV). Moreover, FT-IR and DSC revealed changes in the physicochemical structure of starch resulting in SNPs formation. The entrapment efficiency was 97% ± 0.45%, and the in-vitro release showed that the SNPs enhanced the solubility of the TPD. The in-vivo animal study and histopathology showed that SNPs enhanced the oral bioavailability of TPD against solid Ehrlich carcinoma. Conclusion: SNPs-TPD were superior in drug solubility and oral bioavailability than those obtained from TPD suspension.

show abstract

Section: Resultsmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 96%

See 1 more Smart Citation

Starch Nanoparticles for Enhancement of Oral Bioavailability of a Newly Synthesized Thienopyrimidine Derivative with Anti-Proliferative Activity Against Pancreatic Cancer

Gardouh¹,

El-Din²,

Salem³

et al. 2021

DDDT

View full text Add to dashboard Cite

show abstract

“…Different methods of producing starch nanocrystals can also influence on the particle size. [53] The nanoprecipitation method allowed the production of corn nanocrystals in the range of 58 to 73 nm, under optimal conditions, while the microemulsion method resulted in particles from 35 to 147 nm. Xiong et al [54] studied different methods of production of rice starch nanocrystals: nanoprecipitation, alkaline freezing, crosslinking and H 2 SO 4 hydrolysis.…”

Section: Particle Sizementioning

confidence: 99%

From Micro to Nanoscale: A Critical Review on the Concept, Production, Characterization, and Application of Starch Nanostructure

et al. 2021

View full text Add to dashboard Cite

Evaluation of nanoparticles obtained from starch is still on a laboratory scale and many challenges need to be overcome up to the industrial scale. In this review, information about the study and development of nanostarches are reported based on a discussion of concepts, production methods, as well as physico-chemical and technological characterization, safety and applications. The usual methods of producing nanostarches (such as acid hydrolysis, enzymatic pretreatment, high pressure homogenization and ultrasound) are discussed in this review, as well as the advancement of applications in the food industry (as in Pickering emulsion, carriers, films and nanocomposite production). Due to the wide variety of data, a protocol for the analysis of starch nanostructures is suggested. However, methods for quantifying starch nanoparticles are based on yield by weight, and no quantification method has yet been presented for processed products. All reports present a promising future for several areas, both in research and industrial applications, as they are considered as open doors to the many challenges on this research area.

show abstract

“…To overcome the limitations of traditional nanoprecipitation methods in the production of SNPs, hybrid top-down processes have also been used with satisfactory results when a combination of nanoprecipitation and physical treatment has been used for preparation of SNPs. [9] High-speed shearing (HSS), which is frequently used in food industry either to alter food properties or improve its stability, provides a high shear, cavitation, and collision force. [10] Previous studies have shown that HSS had advantages of being simple, faster, and more environmentally friendly in degradation modification with lower processing temperature, higher efficiency, less time, and energy consumption.…”

Section: Doi: 101002/star202100122mentioning

confidence: 99%

Insights into the Relations between Particle Size and Physicochemical Properties of Starch Nanoparticles Prepared by Combining High‐Speed Shearing with Precipitation

Xiao

Zhang

et al. 2021

Starch Stärke

View full text Add to dashboard Cite

This study is the first to investigate the relations between particle size and physicochemical properties of starch nanoparticles (SNPs) prepared by the combination of high-speed shearing and precipitation. Results show that this new approach allows to produce SNPs in nanoscale range of 157.8-859.4 nm by modifying the main operating parameters regarding the effect of starch variety, shearing speed, and shearing time. Interestingly, with decreasing the average particle size of potato starch nanoparticles (PtS-SNPs), the apparent amylose content, solubility, loss modulus, flow behavior index, rapidly digestible starch content, equilibrium hydrolysis percentage, and kinetic constant increased, whereas the swelling power, storage modulus, consistency coefficient, slowly digestible starch content, resistant starch content decreased. These findings suggest the significant impact of average particle size on the physicochemical properties of PtS-SNPs, which provides useful information for the utilization of these size controlled PtS-SNPs with desirable physicochemical properties in product development for different demands. IntroductionStarch is the second most abundant biomass on earth after cellulose, which can be widely used in food, pharmaceutical, textile, and chemical industries with several advantages of low cost, nontoxicity, biodegradable, and compatible with other materials. [1] However, native starches are inscrutable for many applications, hence, they are modified to extend the applications range in other areas. [2] In recent years, one of the new rising stars which favored many research workers and enterprises is starch nanoparticles (SNPs). In recent years, SNPs have become a topic of increasing

show abstract

Synthesis of controlled size starch nanoparticles (SNPs)

Cited by 49 publications

References 30 publications

Starch Nanoparticles for Enhancement of Oral Bioavailability of a Newly Synthesized Thienopyrimidine Derivative with Anti-Proliferative Activity Against Pancreatic Cancer

Starch Nanoparticles for Enhancement of Oral Bioavailability of a Newly Synthesized Thienopyrimidine Derivative with Anti-Proliferative Activity Against Pancreatic Cancer

From Micro to Nanoscale: A Critical Review on the Concept, Production, Characterization, and Application of Starch Nanostructure

Insights into the Relations between Particle Size and Physicochemical Properties of Starch Nanoparticles Prepared by Combining High‐Speed Shearing with Precipitation

Contact Info

Product

Resources

About