Synthesis of Chitosan-Based Hydrogels as a Novel Drug Release Device for Wound Healing

Abstract

T he development of the porous, biocompatible and biodegradable hydrogels has been gaining much attention for wound dressing applications. The hydrogels prepared using freeze-thawing method present important properties of high biocompatibility and nontoxicity. The hydrogels that are able to release drugs for prolonged time are widely used biomaterials for wound healing. In this study chitosan (CS)-based poly-ε-caprolactone (PCL) hydrogels were prepared using poly vinyl alcohol (PVA), poly ethylene glycol (PEG) and poly vinyl pyrrolidone (PVP). PVA-CS-PCL hydrogels only could remain stable at room temperature after synthesis. The properties of the hydrogels were determined with SEM, FTIR, swelling tests and degradation tests. The drugs of ceftazidime (CZ) as an antibiotic and ketoprofen (KP) as an analgesic were loaded onto the hydrogels and the loaded hydrogels were used for the drug release studies at pH 5.5 and pH 7.4. All these results suggest that the developed PVA-CS-PCL hydrogels offer significant potential as a wound dressing material.

Evaluation of hyaluronic acid nanoparticle embedded chitosan–gelatin hydrogels for antibiotic release

“…The hydrogels were put into the buffer solution and taken from the solution after the determined time period with further drying. The percentage of the weight loss was calculated with the following equation (Tamahkar & Özkahraman, 2017): …”

Advancements and future directions in the antibacterial wound dressings – A review

“…Thus, the delivery of the antibiotics to directly wound area from the wound dressings in a controlled manner is one of the major strategies for wound treatment 66,67 . The wound dressings that release the antibiotics should provide an efficient antibacterial performance, an appropriate moist environment showing no toxicity to host tissue 68 . Some of the general antibiotics that are used for wound healing are aminoglycosides (gentamicin, streptomycin), beta‐lactams (ampicillin, ceftadizime, cefazolin), glycopeptides (vancomycin), quinolones (ciprofloxacin, Levofloxacin), sulphonamides (sulfadiazne), tetracyclines (doxycycline, tetracycline hydrochloride).…”

“…66,67 The wound dressings that release the antibiotics should provide an efficient antibacterial performance, an appropriate moist environment showing no toxicity to host tissue. 68 The healing performance of the antibacterial wound dressing that delivers antibiotics depends on the drug release profile, the physicochemical properties of the drug and the polymeric material. For the effective treatment of the wound infections, the initial burst release, which means the release of about 60% of the loaded drug molecules during the first 5 hr is required followed by the controlled release.…”