Synthesis of chemically cross-linked hydrogel films based on basil seed (Ocimum basilicum L.) mucilage for wound dressing drug delivery applications

Hosseini, Masoomeh Sadat; Nabid, Mohammad Reza

doi:10.1016/j.ijbiomac.2020.06.252

Cited by 66 publications

(25 citation statements)

References 43 publications

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“…Glutaraldehyde (GA) is generally used as a cross-linking agent for polymers containing OH groups (mainly polysaccharides) to increase their ability to have intermolecular reactions with PVA, thus increasing the integrity in aqueous environments. 48 The FTIR spectra of the cross-linked PVA/SSG nanofibers with the GA vapor are presented in Figure 7(b) (the red-colored region). The cross-linking of the PVA/SSG nanofibers with GA could be verified by the decrease in the vibration band of the OH group at 3380–3420 cm −1 .…”

Section: Resultsmentioning

confidence: 99%

Sage seed gum as a novel source for polysaccharide-based antibacterial nanofibers: Physical, chemical, and rheological characterization

Yekrang

Saghafi

Yousefi

et al. 2022

Journal of Industrial Textiles

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In this study, the sage seed gum (SSG) was electrospun as a polysaccharide polymer blended with polyvinyl alcohol (PVA) to construct nanofibrous mats for antibacterial applications. The rheological properties of the PVA/SSG solutions were investigated before electrospinning. Oscillatory, shear, and steady shear tests demonstrated that the PVA/SSG solutions had a viscous behavior, exhibiting a higher consistency coefficient ( k) and a lower flow behavior index ( n) at the higher PVA incorporation levels. The morphological studies by SEM images revealed that the PVA/SSG nanofibers were produced without bead defects within the diameter range of 130–300 nm. The in vitro degradation tests showed that the PVA/SSG nanofibers (at different SSG contents) were degraded by approx. 60–70% of their initial weight after one day of the degradation test. The antibacterial activity against Escherichia coli and Staphylococcus aureus microbial species and biodegradation tests also verified that the produced nanofibers could be implemented for antibacterial applications. The SSG polymer in the form of nanofibers can be, therefore, used as a natural and low-cost polymer for special antibacterial applications such as wound healing.

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Section: Resultsmentioning

confidence: 99%

Sage seed gum as a novel source for polysaccharide-based antibacterial nanofibers: Physical, chemical, and rheological characterization

Yekrang

Saghafi

Yousefi

et al. 2022

Journal of Industrial Textiles

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“…Furthermore, an "ideal" wound dressing should present a WVTR or WVP capable of promoting an adequate microenvironment for the adequate recovery of the injury, where dressings with a high WVTR or WVP may cause skin dryness, increasing the probability of scar formation, and lower values may cause the accumulation of exudates [95,96]. With this perspective, Figure 7 presents the WVTR (Figure 7a) and WVP (Figure 7b) results of the wound dressings formed by bacterial cellulose (sample F1) and the eight (8) samples produced from the incorporation of active components to its matrix (Table S1).…”

Section: Characterization Of Active and Pure Bc Wound Dressings: Phys...mentioning

confidence: 99%

Active Potential of Bacterial Cellulose-Based Wound Dressing: Analysis of Its Potential for Dermal Lesion Treatment

et al. 2022

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The use of innate products for the fast and efficient promotion of healing process has been one of the biomedical sector’s main bets for lesion treatment modernization process. The aim of this study was to develop and characterize bacterial cellulose-based (BC) wound dressings incorporated with green and red propolis extract (2 to 4%) and the active compounds p-coumaric acid and biochanin A (8 to 16 mg). The characterization of the nine developed samples (one control and eight active wound dressings) evidenced that the mechanics, physics, morphological, and barrier properties depended not only on the type of active principle incorporated onto the cellulosic matrix, but also on its concentration. Of note were the results found for transparency (28.59–110.62T600 mm−1), thickness (0.023–0.046 mm), swelling index (48.93–405.55%), water vapor permeability rate (7.86–38.11 g m2 day−1), elongation (99.13–262.39%), and antioxidant capacity (21.23–86.76 μg mL−1). The wound dressing based on BC and red propolis was the only one that presented antimicrobial activity. The permeation and retention test revealed that the wound dressing containing propolis extract presented the most corneal stratum when compared with viable skin. Overall, the developed wound dressing showed potential to be used for treatment against different types of dermal lesions, according to its determined proprieties.

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“…The film's thickness (mm) was measured by a Palmer digital micrometer. The measurements were conducted at different points of each sample and the average value was reported [26].…”

Section: Swelling Index and Thicknessmentioning

confidence: 99%

Fabrication and characterization of boric acid-crosslinked ethyl cellulose and polyvinyl alcohol films as potential drug release systems for topical drug delivery

Aliasgharlou¹,

Sana²,

Khoshbakht³

et al. 2020

Turk J Chem

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In this study, boric acid (BA) is employed as a crosslinking agent to improve the characteristics of two commonly used polymeric films, ethyl cellulose (EC) and polyvinyl alcohol (PVA), for topical drug delivery applications. The developed films are characterized by FTIR spectroscopy and SEM analysis. The results show that the surfaces of the prepared films are even and transparent, except for the BA-modified EC sample. The initial cumulative release for erythromycin (EM) is found to be 0.30 and 0.36 mg/mL for EC and PVA films, which drops to 0.25 and 0.20 mg/mL after BA crosslinking, respectively, after 1 h at 25 °C. Further, the developed formulations are stable for 75 days. Also, the antibacterial activity of the developed formulations is investigated against S. aureus (ATCC® 25923™ and ATCC® 29213™). The obtained data confirm that the application of BA as the crosslinking agent extends the release of EM from EC and PVA polymeric films. The findings of this study suggest that BA-crosslinked EC and PVA films are promising carriers for controlled topical drug delivery applications.

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Synthesis of chemically cross-linked hydrogel films based on basil seed (Ocimum basilicum L.) mucilage for wound dressing drug delivery applications

Cited by 66 publications

References 43 publications

Sage seed gum as a novel source for polysaccharide-based antibacterial nanofibers: Physical, chemical, and rheological characterization

Sage seed gum as a novel source for polysaccharide-based antibacterial nanofibers: Physical, chemical, and rheological characterization

Active Potential of Bacterial Cellulose-Based Wound Dressing: Analysis of Its Potential for Dermal Lesion Treatment

Fabrication and characterization of boric acid-crosslinked ethyl cellulose and polyvinyl alcohol films as potential drug release systems for topical drug delivery

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