Active Potential of Bacterial Cellulose-Based Wound Dressing: Analysis of Its Potential for Dermal Lesion Treatment

Abstract

The use of innate products for the fast and efficient promotion of healing process has been one of the biomedical sector’s main bets for lesion treatment modernization process. The aim of this study was to develop and characterize bacterial cellulose-based (BC) wound dressings incorporated with green and red propolis extract (2 to 4%) and the active compounds p-coumaric acid and biochanin A (8 to 16 mg). The characterization of the nine developed samples (one control and eight active wound dressings) evidenced that the mechanics, physics, morphological, and barrier properties depended not only on the type of active principle incorporated onto the cellulosic matrix, but also on its concentration. Of note were the results found for transparency (28.59–110.62T600 mm−1), thickness (0.023–0.046 mm), swelling index (48.93–405.55%), water vapor permeability rate (7.86–38.11 g m2 day−1), elongation (99.13–262.39%), and antioxidant capacity (21.23–86.76 μg mL−1). The wound dressing based on BC and red propolis was the only one that presented antimicrobial activity. The permeation and retention test revealed that the wound dressing containing propolis extract presented the most corneal stratum when compared with viable skin. Overall, the developed wound dressing showed potential to be used for treatment against different types of dermal lesions, according to its determined proprieties.

Bud-Poplar-Extract-Embedded Chitosan Films as Multifunctional Wound Healing Dressing

“…Recently, propolis has been used as an active component in wound biomaterials for its antimicrobial effects, but to the best of our knowledge, the antibiofilm, antiinflammatory, and cell proliferative activities of chitosan-BPE films have not been evaluated [23,24,[37][38][39][40][41][42]. When formulated in corn-starch-based wound dressing with hyaluronic acid, the proliferation of mouse fibroblasts was observed, but this was due to Human keratinocytes (NCTC 2544) produce a high basal level of ROS; stimulation with BPE reduced in a dose-dependent manner the production of radicals (Figure 15B).…”

Extraction of Antioxidant Compounds from Brazilian Green Propolis Using Ultrasound-Assisted Associated with Low- and High-Pressure Extraction Methods

“…Over the years, records in the literature have been demonstrating the bioactive potential of this resin [7]. Among the examples of bioactivity of this matrix are the antioxidant, antimicrobial, anti-inflammatory, antiparasitic, antiviral, and antitumor actions [8][9][10][11]. In their studies, Silveira et al [12] showed that the antiviral action of green propolis was promising in the treatment of patients with COVID-19, reducing hospitalization time and the development of kidney damage (a common sequela in patients with the disease).…”