Synthesis of Bis-Amide and Hydrazide Containing Derivatives of Malonic Acid and Thiophenoladducts of Acidhydrazones Derived from 2-[(N-acetyl) 2, 5-dichloroanilido] Acetohydrazide

Abstract

Acidhydrazides and their condensation products possessing an azometine-NHN=CH-Proton constitute an important class of compounds for new drug development. In the past several years, numerous compounds with diverse structural features have been reported. Therefore, many researchers have synthesized these compounds as target structures and evaluated their biological activities. Hydrazides, hydrazones and their adducts have displayed diverse range of biological properties such as potential biological activities 1-6 , anti-viral 7-8 , anti-tuberculosis 9-10 , anti-tumor 11-18 , anti-fungal 19-20 , anti-convulsant 21 , anti-helmintic 22 , anti-malarial 23 , anti-Inflammatory 24 , anti-cancer 25-26 , antiproliferative 27-29 , anti-oxidant 30 , agricultural agents 31 .

A review exploring biological activities of hydrazones

“…Good antibacterial activity of hydrazone derivatives (12) was reported by Bawa et al . [ 19 ] Hydrazone derivatives (13), synthesized by Sharma et al .,[ 20 ] exhibited antibacterial activity against various bacterial strains. Antibacterial activity of certain hydrazone derivatives (14) was reported by Kendall et al .…”

A Study on Antitubercular and Antimicrobial Activity of Isoniazid Derivative

“…Having been used as the cornerstone of anti-tuberculosis therapy for more than half a century, much has been learned about the biochemistry and multifaceted modes of action of the frontline drug isoniazid. Indeed, with the enormous global burden of tuberculosis and the alarming rise in the number of clinical isolates displaying drug resistance or increased virulence [9][10][11][12], isonicotinic acid hydrazide has become the single most researched anti tubercular agent [13][14][15]. Isonicotinoylhydrazide (Isoniazid: INH) is one of the most potent anti-TB drugs, used to kill the M. tuberculosis.…”

Analgesic, Anti-Inflammatory, and Antiplatelet Profile of Hydrazones Containing Synthetic Molecules

“…Many effective compounds, such as iproniazide and isocarboxazid, are synthesized by the reduction of hydrazide-hydrazones. Another effective hydrazide-hydrazone is nifuroxazide, which is used as an intestinal antiseptic [26][27][28][29][30]. This review highlights analgesic, anti-inflammatory, antipyretic, and antiplatelets activities shown by hydrazones.…”